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Chardonnay grape seed extract

An extract and grape seed technology, applied in the field of Chardonnay grape seed extract, can solve problems such as less ideal and high temperature processing

Inactive Publication Date: 2017-02-22
SHAKLEE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Existing proanthocyanidin extraction methods typically use acidified organic solvents such as methanol, ethanol, or acetone that are not biologically ideal to extract grape seeds, which must be removed before administration to a subject
Other existing extraction methods require high temperature processing

Method used

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  • Chardonnay grape seed extract
  • Chardonnay grape seed extract
  • Chardonnay grape seed extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] method of extraction

[0079] A specific non-limiting embodiment of the extraction process is shown in figure 1 middle. In step (1), Chardonnay grape seeds 1 (fresh, frozen or dried) are washed with drinking water at room temperature. Various weight ratios of water to grape seed can be used, such as a 2:1 to 10:1 ratio, but the example shown uses a 5:1 ratio of water to grape seed [weight:weight], which is obtained by Wash with continuous mixing for 15 minutes. This process is repeated at least two or more times, preferably three times and at most four times. In some examples, the water, eg, the water of the first wash, is neutralized by the addition of alkali to reduce the extraction of polyphenolic compounds into the wash water and simultaneously increase the extraction of sugars into the wash water. In a particular example, the water is neutralized by adding sodium bicarbonate, eg, 0.1% sodium bicarbonate, to the water. Each rinse water is discarded, which main...

Embodiment 2

[0088] analysis results

[0089]Intact Chardonnay grape seeds (fresh grape seeds typically contain 40-50% water) and Fraction A were analyzed by the modified Folin-Ciocalteu method (Singleton and Rossi, Am J Enol Vitic 16:144-158, 1965) , B and C (produced for the first time using an ultrafiltration membrane with a maximum cut-off of 5 kD and for the second time with an ultrafiltration membrane with a maximum cut-off of 500 kD as described in Example 1) and polyphenols compound (gallic acid equivalent [GAE]). As shown in Table 1, Fraction A is almost entirely sugars, 90% of which is fructose and glucose. Fraction B mainly comprised low molecular weight polyphenolic compounds such as monomeric and dimeric flavanols (see Tables 2 and 3 below) and a small amount of fiber. Fraction C contained flavanol oligomers and polymers (tannins) as described in Tables 2 and 3 below and was rich in fiber. Importantly, Fractions B and C contained very low levels of lipids (<1%), compared to...

Embodiment 3

[0100] cleaning steps

[0101] This example illustrates the beneficial effect of seed washing prior to ultrafiltration on polyphenol yield. Although seed washing was shown to increase phenolic recovery at lower extraction temperatures, the washing step was not an essential component of the method disclosed in Example 1. In contrast, the washing step provides additional benefits to the separation method described separately in Example 1 and thus should not be considered a requirement of the method.

[0102] Although the main purpose of the disclosed extraction process is to separate the different components of grape seeds for use in different applications, improving yield efficiency (both by weight and polyphenolic compounds) contributes to better commercial viability. sex. As noted above, existing processes often include harsh solvents and / or high extraction temperatures to maximize extraction yields, but these conditions are undesirable for a variety of reasons. Especially...

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Abstract

A novel grape seed extract is enriched in procyanidins, has total polyphenols of less than 70%, and has a low degree of polymerization (dp). Other fractions of the extract have minimal polyphenols, fiber, and protein, but contain more than 90% sugars. In some specific examples, the individual extracts are obtained by sequential ultrafiltration of a water extract of the grape seeds. A first ultrafiltration provides a first permeate (Fraction A) enriched in sugars which is useful as a flavorant, and a first retentate. The first retentate is reconstituted and subjected to a second ultrafiltration at a higher molecular weight cutoff to produce a second permeate (Fraction B) that is enriched in low molecular weight polyphenols, and a second retentate (Fraction C) that is enriched in seed fiber. The Fractions are individually suitable for different nutraceutical products, or can be combined with each other in any combination and / or with other nutraceutical agents to enhance vascular and cognitive health.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 62 / 005,708, filed May 30, 2014, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure relates to grape seed extract, grape seed extraction process and methods of obtaining extract fractions for use in the manufacture of products with health benefits. Background technique [0004] Fruit and vegetable consumption reduces the risk of several chronic diseases, especially cardiovascular disease and cancer (Fung et al., Am J Clin Nutr 92:1429-1435, 2010). Although fruits and vegetables are great sources of vitamins and minerals, the beneficial effects of these foods are largely attributable to their fiber and antioxidant content. Selected vitamins, such as vitamins C and E, perform antioxidant activity primarily through the direct scavenging of oxygen and nitrogen free radicals. The wide variety of phe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L2/04A23L2/39A23L33/105A23L27/10
CPCA23L2/04A23L2/39A23L27/10A23L33/10A23L33/105A23L33/15A23L2/52A61P1/12A61P25/28A61P3/02A61P43/00A61P9/00A23V2002/00A23V2250/2132A23L5/25A23L2/74A61K36/87A61K2236/331A61K2236/37A61K2236/50A61K2236/51
Inventor 特奥多罗·T·安尼罗劳勒尔·A·费舍
Owner SHAKLEE CORP
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