Laminate and production method therefor

Abstract

Provided is a laminate characterized by having at least one polylactic acid resin-containing layer (C) with a thickness of 10-500 nm on at least one surface of a fibrous structure (B) containing a water-soluble resin (A). Also provided is a production method for the laminate, said method being characterized in that water or an aqueous solution is applied to the joining surface of the fibrous structure (B) and the polylactic acid resin-containing layer (C). A laminate according to the present invention exhibits superior tracking, adhesion and coating properties relative to flexible, curved objects, exhibits superior compatibility to organs such as skin and internal organs, and, because the fibrous structure (B) containing a water-soluble resin (A) can easily be removed from the polylactic acid resin-containing layer (C) by means of the aqueous solution, is optimal for use in materials for external use on the skin, such as wound-covering materials, adhesion-preventing materials, and skin care products.

Description

technical field [0001] The present invention relates to a laminate having a fibrous structure made of a water-soluble resin and a layer made of a polylactic acid resin, which is most suitable for medical applications such as a wound covering film and an anti-adhesion film, and a method for producing the same. Background technique [0002] In surgical operations represented by abdominal surgery, plastic surgery, and neurosurgery, one of the postoperative complications is the problem of adhesion between organs. The problem is that if the normal tissues damaged by desiccation and oxidation are sutured to each other by surgery, in the process of gradually self-healing through wound healing, adhesion phenomenon sometimes occurs, that is, the organs and tissues that should not be joined together are attached to each other. join. Adhesions are believed to occur at a high rate during surgery and are sometimes associated with complications leading to pain, intestinal embolism (intes...

AI Technical Summary

Problems solved by technology

However, when gelatin and collagen are used, there is a problem that it is difficult to remove the antigenic telopeptide portion, and there is a risk of contamination of animal-derived infectious diseases such as prions, so it is considered that they should be avoided for use in living organisms.

However, materials using polysaccharides have insufficient strength, and there is a problem that suturing is difficult due to insufficient strength.

In addition, even if it can be stitched, it is difficult to maintain the stitched state for a certain period of time

[0009] In addition, there are also reports on anti-adhesion materials using hyaluronic acid (for example, Patent Document 4), but due to poor adhesion to organs, the film and organs tend to shift, resulting in adhesion, etc., and it cannot be said that it has certain properties. Sufficient performance, in addition, there is a problem of high manufacturing cost due to difficulty in mass production

There is also a method of using blood preparations and a method of using chemical substances in order to firmly adhere the anti-adhesion film to organs, etc., but there is a problem that it requires high management in terms of sanitation and safety, and it is difficult to handle

However, there is a problem that, due to the thickness of the adhesive layer, the bendability of the laminate is inferior to that of the fibrous structure (B) alone, the flexibility is impaired, or the area in contact with the fibrous structure (B) is small. lead to poor adhesion

However, there is a problem that since it is necessary to open holes in the layer (C) containing polylactic acid-based resin, it cannot be used when it is desired to block the passage of liquid, gas, etc. through the layer. In the case of thinner layer (C), the needle will be severely damaged when penetrating

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