Preparation method of controllably degraded O-carboxymethyl cinnamaldehyde-modified chitosan antibacterial film

A technology of carboxymethyl chitosan and carboxymethyl meat, which is applied in the field of preparation of controllable degradation of O-carboxymethyl cinnamaldehyde modified chitosan antibacterial film, can solve the uncontrollable degradation rate and the inability to prepare film materials , complex production process and other issues, to achieve excellent application value, easy to obtain raw materials, and simple preparation methods

Active Publication Date: 2017-03-01
南通药享科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the degradation performance is very good, its disadvantages are: the air permeability of the membrane is poor, the degradation rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0055] Example 1

[0056] (1) Preparation of carboxymethyl chitin

[0057] 5g of chitin was swelled in 50mL of isopropanol at room temperature for 2h and then placed in an ice-salt bath at -2°C for cooling, and 30mL of 50% NaOH solution was slowly added dropwise, stirred uniformly, and swelled at -2°C for 2h. 10g of chloroacetic acid was heated and dissolved in 10mL of isopropanol in a water bath, slowly added dropwise to the chitin solution under stirring, and stirred in a water bath at 50°C for 4h. Centrifugal sedimentation, decant the supernatant, add 45 mL of distilled water, 10% hydrochloric acid solution pH to neutral, suction filtration, wash with 75% methanol, 95% ethanol, respectively, and vacuum dry for 12 hours.

[0058] (2) Preparation of O-carboxymethyl chitosan by deacetylation of carboxymethyl chitin

[0059] Take 2.5 g of the product obtained in (1), dissolve it in 50 mL of 50% NaOH solution, stir at 50°C for 1 hour, add 10 mL of deionized water, stir, filter with suc...

Example Embodiment

[0064] Example 2

[0065] (1) Preparation of carboxymethyl chitin

[0066] 5g of chitin was swelled in 45mL of isopropanol at room temperature for 3h and then placed in an ice-salt bath at -5°C to cool, and 30mL of 50% NaOH solution was slowly added dropwise, stirred uniformly, and swelled at -5°C for 2h. 9g of chloroacetic acid was heated and dissolved in 9mL of isopropanol in a water bath, slowly added dropwise to the chitin solution under stirring, and stirred in a water bath for 5 hours at 50°C. Centrifugal sedimentation, decant the supernatant, add 43mL of distilled water, 10% hydrochloric acid solution to adjust the pH to neutral, suction filtration, respectively wash with 75% methanol, 95% ethanol, and vacuum dry for 12h.

[0067] (2) Deacetylation of carboxymethyl chitin to prepare O-carboxymethyl chitosan

[0068] Take 2.5 g of the product obtained in (1), dissolve it in 50 mL of 50% NaOH solution, stir at 50°C for 1 hour, add 10 mL of deionized water, stir, filter with suct...

Example Embodiment

[0073] Example 3

[0074] (1) Preparation of carboxymethyl chitin

[0075] 5g of chitin was swelled in 50mL of isopropanol at room temperature for 2h and then placed in an ice-salt bath at -3°C for cooling, and 30mL of 50% NaOH solution was slowly added dropwise, stirred uniformly, and swelled at -3°C for 1h. 8g of chloroacetic acid was heated and dissolved in 8mL of isopropanol in a water bath, slowly added dropwise to the chitin solution under stirring, and stirred in a water bath for 4.5 hours at 50°C. Centrifugal sedimentation, decant the supernatant, add 41 mL of distilled water, 10% hydrochloric acid solution to adjust the pH to neutral, suction filtration, wash with 75% methanol, 85% ethanol, respectively, and vacuum dry for 12 hours.

[0076] (2) Deacetylation of carboxymethyl chitin to prepare O-carboxymethyl chitosan

[0077] Take 2.5g of the product obtained in (1), dissolve it in 50mL of 50% NaOH solution, stir at 50℃ for 2h, add 10mL of deionized water, stir, filter with...

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PUM

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Abstract

The invention discloses a preparation method of a controllably degraded O-carboxymethyl cinnamaldehyde-modified chitosan antibacterial film. The preparation method comprises (1) preparation of carboxymethyl chitin, (2) preparation of O-carboxymethyl chitosan through carboxymethyl chitin deacetylation, (3) preparation of O-carboxymethyl cinnamaldehyde-modified chitosan, and (4) preparation of the controllably degraded antimicrobial film. The controllably degraded film has salmonella, escherichia coli, staphylococcus aureus and aspergillus niger inhibition activity better than those of single chitosan and the traditional cinnamaldehyde-modified chitosan antibacterial film, has good physical properties and breathability and a controllable degradation rate, can be widely used in fields of agriculture, medicines and food packaging preservation and antibiosis. The preparation method is simple, is easy to operate and has good practicability.

Description

technical field [0001] The invention belongs to the field of preparation of medical antibacterial films, in particular to a preparation method for controllable degradation of O-carboxymethylcinnamaldehyde modified chitosan antibacterial films. Background technique [0002] Chitin is a natural polymer whose biosynthesis amount is second only to cellulose in nature. Its main source is the shell of crustaceans such as shrimps and crabs and the cell walls of some fungi and algae. It is the only alkaline cationic polymer that exists in large quantities in nature. polysaccharides. Chitin has good physiological adaptability and biodegradability, and is an important class of biomedical materials. However, due to its poor solubility, chitin is generally modified, and the most common method is to generate chitosan through deacetylation. [0003] Cinnamaldehyde is an aldehyde compound, a yellow liquid, which is abundant in cinnamon and other plants. Natural products mainly exist in c...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L91/00C08K5/07C08J5/18C08B37/08
CPCC08B37/003C08J5/18C08J2305/08C08J2491/00C08L5/08C08L2201/06C08L2203/16C08L2205/03C08L91/00C08K5/07
Inventor 侯昭升尹胜男刘小龙张娜
Owner 南通药享科技有限公司
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