a rapid hemostatic agent

A kind of hemostatic agent, rapid technology, applied in the field of hemostatic agent, rapid hemostatic agent, can solve problems such as temperature rise, achieve the effect of avoiding pain, preventing bacterial infection and deterioration, and promoting wound healing

Active Publication Date: 2018-02-13
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing hemostatic agents with microporous starch as the main body will produce different degrees of temperature rise during the hemostasis process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This example provides a quick hemostatic agent. The raw materials for preparation include microporous starch, calcium ions, and chitosan or chitin. For every 100g of microporous starch, the amount of chitosan or chitin added is 30g, and calcium ions are added. The amount is 20 μmol, in which chitosan or chitin can be added separately or mixed.

[0036] The preparation method of the quick hemostatic agent in this embodiment is:

[0037] (1) Activation of corn microporous starch

[0038] Weigh 1.0 kg of corn microporous starch, leave it in a vacuum dryer at room temperature for 24 hours, and then wash with 5 volumes of absolute ethanol twice and 12 volumes of acetone for three times, then pump with G2 sand core funnel Filter to dryness, leave it in a vacuum desiccator at 45°C for 24 hours, then transfer it to a container filled with high-purity nitrogen.

[0039] (2) The addition of chitin and / or chitosan

[0040] Add 300 grams of chitin, or 300 grams of chitosan, or a mixture of...

Embodiment 2

[0100] This example provides a quick hemostatic agent. The raw materials for preparation include microporous starch, calcium ions, and chitosan or chitin. For every 100 g of microporous starch, the amount of chitosan or chitin added is 1 g, and calcium ions are added. The amount is 10 μmol, in which chitosan or chitin can be added separately or mixed.

[0101] The test method of the rapid hemostatic agent in this example is the same as that in Example 1, and the results obtained are as follows:

[0102] The average time to complete hemostasis of rabbit ear wounds in self-made hemostatic agent group, Yunnan Baiyao group and negative control group were (94±3) s, (217±4) s and (300±6) s, respectively. The average time to complete hemostasis in rabbit liver wounds were respectively It is (50±2)s, (131±3)s and (210±5)s. The hemostatic effect is significantly better than that of the commercially available Yunnan Baiyao, and the hemostasis time for different animal wounds is also within ...

Embodiment 3

[0104] This example provides a quick hemostatic agent. The raw materials for preparation include microporous starch, calcium ions and chitosan or chitin. For every 100g of microporous starch, the amount of chitosan or chitin added is 50g, and calcium ions are added. The amount is 500 μmol, in which chitosan or chitin can be added separately or mixed.

[0105] The test method of the rapid hemostatic agent in this example is the same as that in Example 1, and the results obtained are as follows:

[0106] The average time for complete hemostasis of rabbit ear wounds and rabbit liver wounds in self-made hemostatic agent group, Yunnan Baiyao group and negative control group was (91±3)s and (51±1)s, (216±2)s and (133±s), respectively 4) s, (303±4)s and (213±4)s, the hemostatic effect is significantly better than the commercially available Yunnan Baiyao, and the hemostasis time for different animal wounds is also within 100 seconds. In addition, compared with Example 2, when the addition...

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Abstract

The invention relates to a rapid hemostatic agent. The preparation raw materials include microporous starch, calcium ions or zinc ions, chitosan or chitin. For every 100g of microporous starch, the amount of chitosan or chitin added is 1-50g, the amount of calcium ions added is 10-500μmol or the amount of zinc ions added is 6-80μmol. The rapid hemostatic agent of the present invention will not cause the skin temperature at the wound to rise significantly when used, and can effectively prevent the temperature at the wound from rising significantly when hemostasis is used, avoiding the risks to patients caused by the increase in the temperature at the wound when the existing hemostatic agent is used. It can be used to stop bleeding from internal and external trauma under various small and medium-sized arteries.

Description

Technical field [0001] The invention belongs to the technical field of novel hemostatic materials, and relates to a hemostatic agent, in particular to a rapid hemostatic agent that can prevent the temperature of a wound from rising. Background technique [0002] At present, the traditional hemostatic materials commonly used in surgical operations include oxidized cellulose, absorbable gelatin sponge, collagen sponge, and zeolite. Although they can all be used as local hemostatic materials, each has major shortcomings and limits its clinical application. For example, the zeolite hemostatic agent releases a large amount of heat energy to increase the local temperature during the application process, resulting in the side effect of tissue thermal burns, which severely restricts its application. [0003] Experimental studies have found that during the process of hemostasis, the hemostatic agent absorbs a large amount of water in the blood. If the process is completed instantly, the hem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/02
CPCA61L24/0015A61L24/0036A61L24/0042A61L24/02A61L24/08A61L2300/232A61L2300/404A61L2400/04C08L3/02C08L5/08
Inventor 边文海李倩陈秀王超展边六交
Owner NORTHWEST UNIV
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