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A kind of cleaning antifouling type amphiphilic copolymer network and preparation method thereof

An amphiphilic copolymer, anti-fouling technology, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, prostheses, etc., can solve the problem of reducing the mechanical properties of the network, achieve chemical modification methods clean, good swelling performance , causing a variety of effects

Active Publication Date: 2019-06-21
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method tends to produce dangling chains and reduce the mechanical properties of the network.

Method used

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  • A kind of cleaning antifouling type amphiphilic copolymer network and preparation method thereof
  • A kind of cleaning antifouling type amphiphilic copolymer network and preparation method thereof
  • A kind of cleaning antifouling type amphiphilic copolymer network and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] A clean antifouling type amphiphilic copolymer network, the preparation method of which is:

[0068] The first step: 3.2wt% RAFT reagent [2-(dodecyl trithiocarbonate group)-2-methylpropionic acid], 0.3wt% DMAP (4-dimethylaminopyridine), 2.6 wt% of DCC (N, N'-dicyclohexylcarbodiimide), 5.8wt% of PEG (polyethylene glycol, Mw=2k) and 88.1wt% of anhydrous dichloromethane were mixed, and put into four Fluorine stirring magnet, at room temperature (25 ° C) magnetic stirring reaction for 48 hours, the mixture was passed through a neutral alumina chromatography column (eluent is dichloromethane), the obtained filtrate was concentrated by rotary evaporation in vacuo, and washed with 10 Extract, wash and purify with ice n-hexane at 0°C, which is twice the amount of the product, and re-dissolve with dichloromethane after cold suction filtration. After several times of extraction and dissolution, the product was dried in a vacuum oven at 60°C to constant weight to obtain a light y...

Embodiment 2

[0075] A clean antifouling type amphiphilic copolymer network, the preparation method of which is:

[0076] The first step: utilize polyethylene glycol to prepare hydrophilic macromolecular chain transfer agent: 3.2wt% RAFT reagent [2-(dodecyl trithiocarbonate group)-2-methyl propionic acid], 0.4wt% of DMAP (4-dimethylaminopyridine), 2.6wt% of DCC (N, N'-dicyclohexylcarbodiimide), 5.8wt% of PEG (polyethylene glycol, Mw=4k) and The anhydrous dichloromethane of 88wt% is mixed, and put into tetrafluoro stirring magnet, at room temperature (25 ℃) after magnetic stirring reaction 48 hours, make mixture pass through neutral alumina chromatography column (eluent is dichloro Methane), the obtained filtrate was concentrated by rotary evaporation in vacuum, and extracted, washed and purified with 0°C ice n-hexane 10 times the amount of the product, and re-dissolved with dichloromethane after cold suction filtration. After several times of extraction and dissolution, the product was dri...

Embodiment 3

[0088] A clean antifouling type amphiphilic copolymer network, the preparation method of which is:

[0089] The first step: 3.2wt% RAFT reagent [2-(dodecyl trithiocarbonate group)-2-methylpropionic acid], 0.4wt% DMAP (4-dimethylaminopyridine), 3.3 wt% of DCC (N, N'-dicyclohexylcarbodiimide), 11.2wt% of PEG (polyethylene glycol, Mw=6k) and 81.9wt% of anhydrous dichloromethane were mixed, and put into four Fluorine stirring magnet, at room temperature (25 ° C) magnetic stirring reaction for 48 hours, the mixture was passed through a neutral alumina chromatography column (eluent is dichloromethane), the obtained filtrate was concentrated by rotary evaporation in vacuo, and washed with 10 Extract, wash and purify with ice n-hexane at 0°C that is twice the amount of the product, and re-dissolve with dichloromethane after cold suction filtration. After several times of extraction and dissolution, the product was dried in a vacuum oven at 60°C to constant weight to obtain a light ye...

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Abstract

The invention provides a clean and anti-pollution and amphiphilic copolymer network and a preparation method thereof. The copolymer network is characterized in that the preparation method includes the steps of preparing a hydrophilic macromolecular chain transfer agent using polyethylene glycol, conducting RAFT polymerization of the hydrophilic macromolecular chain transfer agent and a hydrophobic monomer to prepare an amphiphilic block copolymer, removing a trithioester group at the terminal of the amphiphilic block copolymer through an aminolysis reduction method, conducting modifying through a sulfydryl-alkene click chemical method and using UV-light to trigger crosslinking to prepare the clean and anti-pollution and amphiphilic copolymer network. The amphiphilic copolymer network has the advantages of being high in mechanical strength, transparency, toughness and thermodynamic stability and excellent in swelling property in water phase and oil phase and the like, can be widely applied in drug sustained release, contact lenses, biological catheters and other biomedical fields, has a good prospect in preparation of antifouling coatings, and can be applied in marine antifouling coatings. The invention further discloses the method for preparing the clean and anti-pollution and amphiphilic copolymer network.

Description

technical field [0001] The invention belongs to the field of biological antifouling materials, and in particular relates to a preparation method of a novel amphiphilic copolymer network with a microphase separation structure and its application in the field of biomedicine. Background technique [0002] Amphiphilic Conetworks (APCNs) has been a widely used biopolymer material since it was first reported in 1988. It is connected by covalent bonds to two continuous hydrophilic segments and hydrophobic segments (HI / HO). These two segments are aggregated to form a microphase-separated phase structure, and each retains its original state. Physical and chemical properties, it is an "intelligent polymer network" with medium (solvent) responsiveness and morphological isomerization. The well-known soft contact lens is an APCN that combines highly hydrophilic phases (usually PDMAAm and PNVP) with highly hydrophobic PDMS. As early as 1971, Bausch & Lomb had made soft contact lenses ( ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G77/442C08F299/00C08F293/00C08F220/40C08F8/30C08F8/00A61K47/32A61K47/34A61L27/16A61L27/18G02C7/04
CPCA61K47/32A61K47/34A61L27/16A61L27/18C08F8/00C08F8/30C08F220/40C08F293/005C08F299/00C08F2800/20C08F2810/30C08G77/442G02C7/04C08L57/00C08L83/10
Inventor 何春菊张成风
Owner DONGHUA UNIV
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