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A preparation method of a highly sensitive stretchable biosensor for in situ detection

An in-situ detection and sensitive technology, applied in the direction of instruments, applications, ceramic products, etc., can solve the problems of low sensitivity, difficult stretching, and insufficient stretching stability of biosensors, and achieve simple and controllable methods, low defect peaks, Effect of high chemisorption and physical enhancement mechanisms

Active Publication Date: 2019-05-28
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the shortcomings of current biosensors such as low sensitivity, difficult stretching, and insufficient stretching stability, the present invention proposes a preparation method for a highly sensitive stretchable biosensor that can be used for in-situ detection; Materials with extensibility (stretch length greater than 300%) - stretchable molybdenum disulfide structure - preparation method and combining it with silver nanoparticles to enhance sensitivity and prepare stretchable hybrid structures

Method used

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  • A preparation method of a highly sensitive stretchable biosensor for in situ detection
  • A preparation method of a highly sensitive stretchable biosensor for in situ detection
  • A preparation method of a highly sensitive stretchable biosensor for in situ detection

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Embodiment 1

[0055] Three-dimensional molybdenum disulfide is obtained by growing molybdenum disulfide on nickel foam on a three-dimensional three-dimensional substrate, and finally a mixed structure of molybdenum disulfide / silver nanoparticles is obtained, such as figure 1 The preparation roadmap includes the following preparation steps:

[0056] 1. Add 0.25g (NH 4 ) 2 MoS 4 Add to 20ml of dimethylformamide (DMF) to form a concentration of 1.25wt% and sonicate for 20min.

[0057] 2. Take the nickel foam with a size of 8cm×8cm and wash it in acetone.

[0058] 3. Dry at 80°C for 10 minutes.

[0059] 4. Dip the dried nickel foam in (NH 4 ) 2 MoS 4 Formed in solution (NH 4 ) 2 MoS 4 film.

[0060] 5. Dry at 120°C for 30 minutes.

[0061] 6. Place in a tube furnace.

[0062] 7. Turn on the vacuum pump to pump the air pressure of the tube furnace to the ultimate vacuum state of 3×10 -6 Torr;

[0063] 8. Keep vacuum 3×10 -6 After Torr for 15 minutes (the effect of vacuum for 15 m...

Embodiment 2

[0089] The three-dimensional molybdenum disulfide is obtained by growing molybdenum disulfide on the copper foam of the three-dimensional substrate, and finally the mixed structure of molybdenum disulfide / silver nanoparticles is obtained, including the following preparation steps:

[0090] 1. Add 0.25g (NH 4 ) 2 MoS 4 Add to 20ml of dimethylformamide (DMF) to form a concentration of 1.25wt% and sonicate for 20min.

[0091] 2. Take the copper foam with a size of 7cm×8cm and place it in acetone for cleaning.

[0092]3. Dry at 80°C for 10 minutes.

[0093] 4. Dip the dried copper foam in (NH 4 ) 2 MoS 4 Formed in solution (NH 4 ) 2 MoS 4 film.

[0094] 5. Dry at 120°C for 30 minutes.

[0095] 6. Place in a tube furnace.

[0096] 7. Turn on the vacuum pump to pump the air pressure of the tube furnace to the ultimate vacuum state of 3×10 -6 Torr;

[0097] 8. Keep vacuum 3×10 -6 After 15 minutes of Torr (the effect of vacuum for 15 minutes is to remove impurities, air...

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Abstract

The invention relates to a method for preparing a highly sensitive and stretchable biosensor for in situ detection, which comprises growing a molybdenum disulfide on a three-dimensional substrate by chemical vapor deposition; and then immersing the prepared molybdenum disulfide / foam metal in the In the etching solution, the metal substrate is removed by controlling the concentration and temperature of the etching solution to obtain a mixed structure of the molybdenum disulfide / metal particles, which is removed from the etching solution, cleaned, and pre-stretched. The 3M stretchable tape is covered on the surface of the molybdenum disulfide / metal particle mixed structure and naturally dried to restore the original length or area. It is soaked into stannous chloride, silver nitrate, ascorbic acid and silver nitrate. The solution is mixed to grow silver particles. A highly sensitive stretchable biosensor for in situ detection is thus prepared. The biosensor has excellent tensile properties, good stability, high sensitivity, low cost and controllability, and can realize large-scale production and has great application value.

Description

technical field [0001] The invention belongs to the field of stretchable material preparation, in particular to a preparation method of a highly sensitive stretchable biosensor for in-situ detection. Background technique [0002] For today's biosensors, high sensitivity, high stability, and high efficiency are crucial. The highly sensitive in situ SERS technology can detect environmental and agricultural product pollution and the canceration caused by it in real time and quickly, which plays an important role in pollution control and medical diagnosis and treatment. At present, the progress of related research is relatively slow, mainly because it is difficult to prepare highly sensitive stretchable materials. [0003] The three-dimensional molybdenum disulfide material prepared on the three-dimensional substrate has excellent chemical properties of two-dimensional molybdenum disulfide, and at the same time has a larger specific surface area and better flexibility, and the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/00B32B9/04B32B1/06C04B35/547C04B38/04C04B41/88B32B1/00
CPCG01N33/00C04B35/547C04B38/045C04B41/009C04B41/5116C04B41/88B32B3/08B32B9/04B32B2264/105C04B41/4535C04B41/455
Inventor 杨诚刘子函欧佳瑜李天明潘萧萧徐媛媛刘玫姜守振满宝元
Owner SHANDONG NORMAL UNIV
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