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3D-printing artificial skin and preparation method thereof

A 3D printing and 3D printer technology, applied in the field of medical devices, achieves the effects of low price, short preparation time and abundant raw materials

Inactive Publication Date: 2017-03-22
GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The content of the present invention is to provide a 3D printing artificial leather and its preparation method to solve the existing technical defects

Method used

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  • 3D-printing artificial skin and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method for 3D printing artificial leather, comprising the following steps:

[0028] S1: Prepare 0.5mol / L acetic acid solution: dilute acetic acid with deionized water to obtain 0.5mol / L acetic acid solution;

[0029] S2: Preparation of collagen and sodium citrate mixed gel: take 100mL of acetic acid solution prepared in S1, add 4.9g of collagen, and then add 0.1g of anticoagulant composed of sodium citrate and sodium citrate to obtain collagen / anticoagulant Coagulant mixed gel, the mass ratio of described sodium citrate and sodium citrate is 1:1;

[0030] S3: Add the collagen / sodium citrate mixed gel prepared in S2 into the trough of the 3D printer, set the program of the 3D printer according to the three-dimensional data of the damaged skin area obtained by CT scanning, and start the printer to obtain a three-dimensional The dermis layer with a porous structure is solidified after freeze-drying, and the porosity of the three-dimensional porous structure ...

Embodiment 2

[0034] S1: Prepare 0.5mol / L acetic acid solution: dilute acetic acid with deionized water to obtain 0.5mol / L acetic acid solution;

[0035] S2: Preparation of collagen and sodium citrate mixed gel: take 100mL of acetic acid solution prepared in S1, add 5.9g of collagen, and then add 0.1g of anticoagulant composed of sodium citrate, sodium citrate and EDTA to obtain collagen / anticoagulant mixed gel, the mass ratio of the sodium citrate, sodium citrate and EDTA is 1:1:1;

[0036] S3: Add the collagen / sodium citrate mixed gel prepared in S2 into the trough of the 3D printer, set the program of the 3D printer according to the three-dimensional data of the damaged skin area obtained by CT scanning, and start the printer to obtain a three-dimensional The dermis layer with a porous structure is solidified after freeze-drying, and the porosity of the three-dimensional porous structure is 85%, and the pore size is 250 μm;

[0037] S4: Coating one layer of silicone gel layer on the co...

Embodiment 3

[0040] S1: Prepare 0.5mol / L acetic acid solution: dilute acetic acid with deionized water to obtain 0.5mol / L acetic acid solution;

[0041] S2: Preparation of collagen and sodium citrate mixed gel: take 100mL of acetic acid solution prepared in S1, add 6.9g of collagen, and then add 0.1g of anticoagulant composed of sodium citrate, sodium citrate and sodium oxalate to obtain Collagen / anticoagulant mixed gel, the mass ratio of described sodium citrate, sodium citrate and sodium oxalate is 1:1:1;

[0042] S3: Add the collagen / sodium citrate mixed gel prepared in S2 into the trough of the 3D printer, set the program of the 3D printer according to the three-dimensional data of the damaged skin area obtained by CT scanning, and start the printer to obtain a three-dimensional The dermis layer with a porous structure is solidified after freeze-drying, and the porosity of the three-dimensional porous structure is 85%, and the pore size is 250 μm;

[0043] S4: Coating one layer of sil...

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Abstract

The invention discloses 3D-printing artificial skin and a preparation method thereof. The 3D-printing artificial skin comprises a dermis layer and an epidermal layer which are printed by a 3D printer, wherein the dermis layer comprises collagen and anticoagulant, the epidermal layer comprises a silicone gel layer with holes, the silicone gel layer comprises silicone gel and a curing agent, and the diameter of each hole is 1-3 micrometers. The 3D-printing artificial skin is excellent in anticoagulant property, capable of reducing coagulation in an artificial skin stent, capable of keeping the activity of secretory cells and high in repairability.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a 3D printed artificial skin and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body and has the functions of retaining moisture in the body, preventing excessive heat dissipation, ventilating and preventing bacterial invasion. If only a superficial layer or a small area of ​​skin is damaged, new skin will regenerate itself, but if there is a severe trauma, the skin cannot repair itself, and the superficial skin or artificial skin from other parts of the body must usually be grafted to the wound superior. [0003] Most of the advanced artificial skin has epidermis and dermis. When it is implanted in the damaged area, the semi-permeable epidermis can protect, breathe and prevent bacterial invasion. The dermis has a three-dimensional porous scaffold structure. After a few weeks after the operation, as the scaffold co...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/02A61L27/50A61L27/52A61L27/54A61L27/56A61L27/60
CPCA61L27/24A61L27/025A61L27/50A61L27/52A61L27/54A61L27/56A61L27/60A61L2300/412A61L2300/42
Inventor 卢亢陈锦涛吴帅
Owner GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD