Dextromethorphan hydrobromide orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses a dextromethorphan hydrobromide orally disintegrating tablet, which comprises dextromethorphan hydrobromide and auxiliary materials. The auxiliary materials are selected from one or more of beta-cyclodextrin, mannitol, microcrystalline cellulose, magnesium stearate, crosslinked polyvinylpyrrolidone, aspartame, sodium carboxymethylcellulose, lactose, starch, glyceryl behenate, crosslinked carboxymethyl starch and lauryl sodium sulfate. Compared with the prior art, the dextromethorphan hydrobromide orally disintegrating tablet provided by the invention has shorter disintegration time and better taste than traditional tablets and capsules, can rapidly disintegrate and dissolve out in an oral cavity without the need for taking with water, takes effect rapidly, and can be conveniently taken by the aged, the children and patients with difficulty in taking medicine, and the effectiveness, the safety and the compliance of a medicine are improved. A preparation method adopts common equipment, and is low in production cost and suitable for industrial production. The dextromethorphan hydrobromide orally disintegrating tablet is applicable to relieving throat discomfort caused by cold, acute tracheitis, bronchitis and allergy.

Description

technical field [0001] The invention relates to a dextromethorphan hydrobromide orally disintegrating tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] With the increasing air pollution in recent years, the number of patients with respiratory diseases has also increased. The drug use of the elderly, young children and patients with dysphagia is also one of the key points of research by medical workers. In recent years, orally disintegrating tablets, as a new type of oral preparation, have largely solved this problem. [0003] As a new type of oral tablet, orally disintegrating tablet has clear requirements for its disintegration time limit and environment. The Drug Evaluation Center of the State Food and Drug Administration (SFDA) established the basic quality control requirements for the disintegration time limit of orally disintegrating tablets in the "Dosage Form Characteristics and Quality Control Meeti...

AI Technical Summary

Problems solved by technology

However, the elderly, children and some patients with swallowing dysfunction have poor compliance with the above preparations

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