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Preparation method of spray type chitosan aqueous solution wound dressing

A wound dressing and chitosan technology, applied in medical science, bandages, etc., can solve the problems of chemical residues, long film formation time, poor water resistance, etc., and achieve the effect of reducing water content, promoting dissolution, and maintaining fluidity

Active Publication Date: 2017-03-29
山东康康新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it takes a long time to form a film, and because there is acid residue in the formed chitosan film, it will redissolve when it encounters water, resulting in poor water resistance.
In addition, the residues of chemical substances have potential health hazards to the human body

Method used

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  • Preparation method of spray type chitosan aqueous solution wound dressing
  • Preparation method of spray type chitosan aqueous solution wound dressing
  • Preparation method of spray type chitosan aqueous solution wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Using 0.5% acetic acid aqueous solution as a solvent, deacetylation degree of 95%, and chitosan with a viscosity average molecular weight of 100,000 as a raw material, stirring and dissolving to obtain a chitosan solution with a mass percentage concentration of 1%, while using a rotating speed of 10,000rpm The prepared chitosan solution was stirred by a homogenizer, and the sodium hydroxide aqueous solution with a concentration of 1g / L was added dropwise until the pH value of the solution was 7, and the addition of the sodium hydroxide aqueous solution was stopped to obtain a turbid solution of chitosan. The chitosan turbid solution obtained by centrifugation of a high-speed centrifuge with a rotating speed of 10000rpm is used to obtain a chitosan precipitate, and the precipitate is washed with distilled water until the pH value of the washing solution is 7 to obtain a chitosan gel .

[0043] Get the gel body prepared in Example 1 and dry a little, use infrared spectrom...

Embodiment 2

[0048] Using 0.5% acetic acid aqueous solution as solvent, deacetylation degree ≥ 90%, and chitosan with viscosity-average molecular weight of 100,000 as raw material, stirring and dissolving to obtain a chitosan solution with a mass percentage concentration of 1%. 500rpm, 1000rpm, 5000rpm, 10000rpm, 30000rpm homogenizer stirred the obtained chitosan solution, while adding the sodium hydroxide aqueous solution with a concentration of 1g / L dropwise until the pH value of the solution was 7, stop adding sodium hydroxide aqueous solution to obtain a turbid solution of chitosan; the chitosan turbid solution obtained by centrifugal separation of a high-speed centrifuge with a rotating speed of 10000rpm is used to obtain a chitosan precipitate, and the precipitate is washed with distilled water until the pH of the washing solution is 7. Obtain chitosan gel;

[0049] The particle size of the chitosan condensate cloudy solution that adopts laser particle size analyzer test to obtain, i...

Embodiment 3

[0053] Using 0.5% acetic acid aqueous solution as a solvent, deacetylation degree ≥ 90%, and chitosan with a viscosity-average molecular weight of 50,000 as a raw material, stirring and dissolving to obtain a chitosan solution with a mass percentage concentration of 3%, while using a rotating speed of The chitosan solution that the homogenizer of 30000rpm stirs makes, while adding concentration dropwise is the sodium hydroxide aqueous solution of 3g / L, until the pH value of solution is 8, stops adding sodium hydroxide aqueous solution, obtains the turbidity of chitosan solution; the chitosan turbid solution obtained by centrifugation of a high-speed centrifuge with a rotating speed of 10000rpm is used to obtain a chitosan precipitate, and the precipitate is washed with distilled water until the pH of the washing solution is 7 to obtain a chitosan gel body; using a mass percent concentration of 3% glycerol aqueous solution as a solvent, and then using a rotating speed of 30000rp...

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Abstract

The invention provides a preparation method of a spray type chitosan aqueous solution wound dressing. The preparation method comprises the steps that firstly, chitosan is prepared into gel and dispersed into a glycerine water solution; secondly, carbon dioxide is continuously led into the glycerine water solution under the high-pressure and low-temperature condition to prepare a chitosan water solution; and thirdly the chitosan water solution is canned after being sterilized. Proper process parameters are selected by reasonably controlling the stirring rotating speed, the carbon dioxide leading amount and the high pressure range during gel preparation. The preparation method is simple in preparation process and ingenious in design, and the product is novel in form, convenient to use, free of binding and superior in comprehensive performance, and has quite good application prospects in wound repair.

Description

technical field [0001] The invention relates to a preparation method of a spray-coated chitosan aqueous wound dressing, which belongs to the technical field of medical wound dressings. Background technique [0002] The skin has the important functions of resisting the invasion of pathogenic bacteria outside the body, excreting human waste, preventing the evaporation of water in the human body, regulating the temperature of the human body, and sensing external stimuli. When the skin is damaged due to trauma, abrasions, burns, and ulcers, it is easy to cause local or even systemic problems, such as excessive loss of water and protein, immune system imbalance, bacterial infection, etc., which can be serious or even life-threatening. Therefore, when the skin is damaged, it is necessary to use wound dressings to accelerate hemostasis, protect the wound surface, prevent bacterial infection, create a suitable wound repair environment, and accelerate wound healing. Traditional woun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/09C08J3/075
CPCA61L26/0023A61L26/008C08J3/075C08J3/095C08J2305/08C08L5/08
Inventor 张传杰朱平颜超
Owner 山东康康新材料科技有限公司
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