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Method for dry storage of artificial heart valve prosthesis

A kind of artificial heart valve, drying technology, applied in the preservation and application of heart valve, human or animal body, etc., can solve the problems of easy calcification of tissue, cytotoxicity, reduce cost, etc., and achieve the effect of high proximity and elimination of side effects

Inactive Publication Date: 2017-04-26
上海纽脉太惟医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But long-term clinical practice proves, adopts the artificial heart valve of glutaraldehyde cross-linking to process to have following defects: 1) cytotoxic effect, the long-term residual glutaraldehyde in the tissue after cross-linking has cytotoxic effect. Host cell can not be in 2) The presence of aldehyde groups and other reasons lead to calcification of the tissue after cross-linking, and calcification is one of the important reasons for the failure of artificial heart valves; 3) Incomplete elimination of immunogenicity is one of the reasons for calcification and also leads to One of the inflammatory response mechanisms; 4) Residual cells and debris are one of the main sites of tissue calcification and an important source of immunogenicity; 5) Tissues with residual reagents must be washed before implantation
[0009] CN101626682A discloses a prosthetic heart valve for surgical implantation and a processing method thereof, the method of processing the prosthetic heart valve comprises making the prosthetic heart valve with polyhydric alcohol and C 1 -C 3 Alcohol non-aqueous treatment solution contacts, thereby the prosthetic heart valve of processing can restore at least about 97% of its original hydration size, has avoided glutaraldehyde treatment and the defective that preservation prosthetic heart valve brings simultaneously; The time is longer and the amount of solution required is larger, which is not conducive to simplifying the operation and reducing the cost

Method used

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  • Method for dry storage of artificial heart valve prosthesis
  • Method for dry storage of artificial heart valve prosthesis
  • Method for dry storage of artificial heart valve prosthesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The artificial heart valve treated with glutaraldehyde is cut into three groups of similar size, each of 6 pieces, wherein the biological tissue material of the artificial heart valve is bovine pericardium. Measure the size and record it. The artificial heart valve was completely immersed in solution A for 12 hours, and then completely immersed in solution B for 12 hours after being removed, and completely immersed in solution C for 12 hours after being removed. Among them, the volume ratio of solutions A, B, C to the artificial heart valve is 80:1, and the distribution of each group is shown in Table 1.

[0055] Table 1

[0056] Solution combination Solution A Solution B Solution C glycerin75％80％85％ Ethanol 25％20％15％

[0057] Test items:

[0058] 1. Measure and record the diameter and thickness of the artificial heart valve before processing, after drying, and after hydration. The data are read after 5 seconds of stability. The same artificial heart valve was tested 6...

Embodiment 2-8

[0075] Prepare solutions A, B, and C with the components shown in Table 7, and contact the artificial heart valve in the order of solution A→B→C. After testing, the diameter and thickness of it before treatment, after drying and after hydration The rate of change is shown in Table 8.

[0076] Table 7

[0077]

[0078]

[0079] Table 8

[0080]

[0081] It can be seen from the above results that in Examples 1-7, solutions A, B, and C are used to contact the artificial heart valve in the order of solution A→B→C, which can make the size of the artificial heart valve after treatment close to the size before dehydration Higher, making the dry tissue less susceptible to microorganisms; in Examples 1-7, Example 1 compared to other Examples 2-7, it can make the size of the artificial heart valve after treatment the closest to the size before dehydration.

[0082] The present invention also verifies other animal pericardium (such as pig, sheep, kangaroo, etc.), aorta, mitral valve, tricuspid ...

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Abstract

The invention relates to a method for dry storage of an artificial heart valve prosthesis. The method includes the steps that three solutions containing organic solvent and glycerinum make contact with the artificial heart valve prosthesis in sequence; parts of the solutions are removed from the artificial heart valve prosthesis treated through the solutions; and dry storage is achieved after sterilization and refrigeration. The dimension of the artificial heart valve prosthesis treated through the method is basically the same as the dimension before dehydration, the side effect of water is completely eliminated, dry tissue cannot be influenced by microorganisms easily, and therefore medical staff can obtain the artificial heart valve prosthesis in the mode of using as approachable as possible.

Description

Technical field [0001] The invention relates to the field of implant materials, in particular to a method for dry preservation of artificial heart valves. Background technique [0002] The heart is a very important organ of the human body, which provides power for the blood circulation of the human body. The heart is divided into two parts. Each part contains a ventricle and an atrium. There are valves between the chambers, chambers, and arteries to prevent blood reflux. The valve between the left atrium and the left ventricle is the mitral valve, the valve between the right atrium and the right ventricle is the tricuspid valve, the valve between the left ventricle and the aorta is the aortic valve, and the valve between the right ventricle and the aorta is the aortic valve. The valve between the pulmonary arteries is the pulmonary valve. [0003] The above-mentioned valves will open and close correspondingly with the contraction and relaxation of the heart. Therefore, the valves...

Claims

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Application Information

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IPC IPC(8): A01N1/02A61F2/24A61L27/36
Inventor 虞奇峰梁玉晨常丽南秦涛
Owner 上海纽脉太惟医疗科技有限公司
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