Ganoderma spore oil microcapsule powder and preparing method and application thereof

A technology of spore oil microcapsule powder and ganoderma spore oil, which is applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problem of inability to effectively promote the bioavailability of ganoderma spore oil, increase in acid value and peroxide value, and disintegration Unqualified and other problems, to achieve the effect of improving bioavailability, increasing specific surface area, and enhancing immunity

Active Publication Date: 2017-04-26
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ganoderma lucidum spore oil soft capsules face the following problems: disintegration becomes unqualified during storage, oil leakage in capsules, acid value and peroxide value increase and other stability problems
At present, there is no report on the microencapsulation of Ganoderma lucidum spore oil. The microencapsulation technology of other active substances mostly uses emulsifiers, but each active substance has its own special properties. The expected effect of different microencapsulation materials The results are different. The existing microencapsulation technology applied to Ganoderma lucidum spore oil may not be able to effectively promote the bioavailability of Ganoderma lucidum spore oil, and there will also be certain problems in terms of water solubility, dispersibility, and stability.

Method used

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  • Ganoderma spore oil microcapsule powder and preparing method and application thereof
  • Ganoderma spore oil microcapsule powder and preparing method and application thereof
  • Ganoderma spore oil microcapsule powder and preparing method and application thereof

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Embodiment 1

[0029] Embodiment 1: Preparation of Ganoderma lucidum spore oil microcapsule powder of the present invention

[0030] 1. Composition

[0031] Wall material: Ganoderma lucidum spore oil = 3:2, starch sodium octenyl succinate in wall material: maltodextrin = 1:1

[0032] 2. Preparation method

[0033] adding the wall material into ultrapure water, heating and stirring at 80°C to dissolve, and obtaining an aqueous solution of the wall material; wherein the mass concentration of the composite wall material aqueous solution is 30%;

[0034] Add Ganoderma lucidum spore oil to the above-mentioned wall material aqueous solution, and shear 2min at a high speed at a speed of 16000r / min to obtain the primary emulsion; wherein, the mass ratio of the composite wall material to the Ganoderma lucidum spore oil is 3:2; the obtained primary emulsion With high pressure 300Bar and temperature 50℃, homogenize twice to obtain a uniform and stable final emulsion;

[0035] The above homogenized f...

Embodiment 2

[0038] Embodiment 2: preparation Ganoderma lucidum spore oil microcapsule powder of the present invention

[0039] 1. Composition

[0040] Wall material: Ganoderma lucidum spore oil = 3:2, starch sodium octenyl succinate in wall material: maltodextrin = 1:0.5

[0041] 2. Preparation method

[0042] adding the wall material into ultrapure water, heating and stirring at 70°C to dissolve, and obtaining an aqueous wall material solution; wherein the mass concentration of the wall material aqueous solution is 40%;

[0043] Add Ganoderma lucidum spore oil in the above-mentioned wall material aqueous solution, shear 2min at a high speed with the speed of 16000r / min, obtain primary emulsion; Wherein, the mass ratio of described wall material and Ganoderma lucidum spore oil is 3:2; High pressure 300Bar, temperature 50°C, homogenize twice to obtain a uniform and stable final emulsion;

[0044] The above homogenized final emulsion was spray-dried to obtain Ganoderma lucidum spore oil ...

Embodiment 3

[0047] Embodiment 3: preparation Ganoderma lucidum spore oil microcapsule powder of the present invention

[0048] 1. Composition

[0049] Wall material: Ganoderma lucidum spore oil = 3:2, starch sodium octenyl succinate in wall material: maltodextrin = 1:2

[0050] 2. Preparation method

[0051] adding the wall material into ultrapure water, heating and stirring at 90°C to dissolve, and obtaining an aqueous solution of the wall material; wherein the mass concentration of the composite wall material aqueous solution is 50%;

[0052] Add Ganoderma lucidum spore oil to the above-mentioned wall material aqueous solution, and shear 2min at a high speed at a speed of 16000r / min to obtain the primary emulsion; wherein, the mass ratio of the composite wall material to the Ganoderma lucidum spore oil is 3:2; the obtained primary emulsion Homogenize once with high pressure 300Bar and temperature 50°C to obtain a uniform and stable final emulsion;

[0053] The above homogenized final...

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Abstract

The invention relates to the technical field of microcapsule powder, and discloses a ganoderma spore oil microcapsule powder and a preparing method and application thereof. The microcapsule powder comprises ganoderma spore oil and a wall material. The wall material comprises starch sodium octenylsuccinate and maltodextrin. According to the ganoderma spore oil microcapsule powder, starch sodium octenylsuccinate and maltodextrin are adopted as a composite wall material, microencapsulation is conducted on the ganoderma spore oil, not only does the ganoderma spore oil microcapsule powder have good dispersibility, but also times of adoption of homogenization are reduced in the processing process, meanwhile, bioavailability of the ganoderma spore oil can be improved, medicinal activity of the ganoderma spore oil is further improved, and immunity can be remarkably improved.

Description

technical field [0001] The invention relates to the technical field of microcapsule powder, in particular to ganoderma lucidum spore oil microcapsule powder and its preparation method and application. Background technique [0002] Ganoderma lucidum spore oil is a kind of hydrophobic oil extracted from Ganoderma lucidum spores, the main components are saturated fatty acids, unsaturated fatty acids and a small amount of ganoderma acid. Experiments have proved that Ganoderma lucidum triterpenoids have the effect of rapidly improving immunity, and at the same time can activate tumor cells in the G0 phase that are difficult to kill with chemotherapy drugs, and perform poisoning alone and in combination. However, because the triterpenoids of Ganoderma lucidum are unstable, they will be oxidized and volatilized in the air for 2 hours, so preventing the triterpenoids of Ganoderma lucidum from being oxidized is the main standard for improving the content and purity of the active ingr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36A61K36/074A61P37/04
CPCA61K9/5036A61K9/5089A61K36/074
Inventor 肖俊勇陈伟鸿马方励万江陵马忠华
Owner INFINITUS (CHINA) CO LTD
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