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Photo-thermal dual-responsive high-strength hydrogel and its preparation method and application

A dual-response, hydrogel technology, applied in the fields of smart windows, biomedicine, and light-controlled valves, can solve the problems of limited application and poor mechanical properties, and achieve the effect of changing hydrophilicity and hydrophobicity, good fatigue resistance, and fast reversible response.

Inactive Publication Date: 2017-04-26
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the poor mechanical properties of conventional hydrogels limit their applications

Method used

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  • Photo-thermal dual-responsive high-strength hydrogel and its preparation method and application
  • Photo-thermal dual-responsive high-strength hydrogel and its preparation method and application
  • Photo-thermal dual-responsive high-strength hydrogel and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0032] Synthesis of γ-PGA-GMA (Mn=1000000g / mol): first accurately weigh 4.01g of γ-PGA dissolved in 100mL of 5wt% NaHCO 3 In the aqueous solution, stir slowly until the γ-PGA is fully dissolved, then let stand to remove air bubbles; then add 0.1g 4-dimethylaminopyridine (DMAP), stir and dissolve fully, continue to slowly add 4.1mL glycidyl methacrylate ( GMA). Then the above solution was slowly stirred and reacted for 60 hours in the dark, and then the reacted solution was put into a dialysis bag with a molecular weight cut-off of 3500 and dialyzed in distilled water for three days, changing the water at least three times a day, and finally freeze-dried to obtain the target product γ-PGA- GMA. Its structure was characterized by nuclear magnetic technology, and its grafting rate was calculated to be 10%.

Embodiment 2

[0034] Synthesis of spiropyran monomer SPMA: All reaction vessels were wrapped with aluminum foil and protected from light.

[0035] (1) Accurately measure 10.1mL (0.06mol) of 2,3,3-trimethyl-3H-indole and 12.6g (0.06mol) of 3-iodopropionic acid and heat to 100°C under nitrogen for 3 hours; The remaining solid was dissolved in deionized water and washed with chloroform, then evaporated to remove water to obtain the iodide intermediate product-intermediate A, with a yield of 75%; its structural formula is as follows:

[0036]

[0037] (2) 14g (0.04mol) of intermediate A, 6.5g (0.04mol) of 5-nitrosalicylaldehyde and 3.8mL (0.04mol) of piperidine were dissolved in methyl ethyl ketone to obtain a red reaction solution, Refluxing for 3 hours; then standing overnight, a yellow powdery solid precipitated out. It was then filtered and washed repeatedly with methanol to obtain intermediate B with a yield of 78%. Its structural formula is as follows:

[0038]

[0039] (3) Accur...

Embodiment 3

[0041] Prepare γ-PGA-GMA (Mn=1000000g / mol, grafting rate 10%) aqueous solutions with mass concentrations of 0.02g / mL and 0.03g / mL respectively, and add photoinitiator Irgacure 2959 to make the concentration 0.0005g / mL, centrifuged to remove air bubbles. Pipette the above solution and place it in a mold, and irradiate it under ultraviolet light with a wavelength of 365nm for 10 minutes to obtain the first network hydrogel γ-PGA hydrogel, named PGA2 and PGA3 respectively, and test its mechanical properties on a universal testing machine performance.

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Abstract

The invention discloses spiropyran-based photo-thermal dual-responsive high-strength dual-network hydrogel and its preparation method and application. The preparation method comprises that poly(gamma-glutamic acid)glycidyl methacrylate is crosslinked to form a first network, the first network is swollen in a prepolymer solution containing ethyl 2-[1-acrylate-3', 3-dimethyl-6-nitro-spiro[indoline-2', 2-[2H-1]]-benzopyran]methacrylate and N-isopropylacrylamide until the swelling is complete, and the swollen product is taken out and is crosslinked to form the dual-network hydrogel. The dual-network hydrogel contains a photochromic spiropyran monomer and a temperature-responsive NIPAAm monomer so that the dual-network hydrogel has good mechanical properties, response to light and temperature stimulation, and a good application prospect in drug loading, biosensors and smart windows.

Description

technical field [0001] The invention relates to a high-strength hydrogel based on spiropyran modification with photothermal dual response and its preparation method and application, belonging to the fields of light control valves, intelligent windows and biomedicine. Background technique [0002] Smart materials refer to a class of materials that can change their physical and chemical properties in response to stimuli such as temperature, pH, magnetic field, and light. Among these types of stimuli, light stimuli have attracted increasing attention due to their easy-to-obtain and non-invasive characteristics. Spiropyrans are a class of organic compounds that can respond to various stimuli, such as light, pH, mechanical force, electric field and certain metal ions. When irradiated by ultraviolet light, spiropyran can undergo a ring-opening reaction, and the monomer is converted from a hydrophobic colorless ring-closed structure into a hydrophilic colored ring-opened body (mer...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L55/00C08L33/24C08F299/02C08F2/48C08G69/48C08F220/54C08F222/38C08F222/22
CPCC08F2/48C08F220/54C08F299/02C08G69/48C08J3/075C08J2333/24C08J2355/00C08L33/24C08L55/005C08L2205/04C08F222/385C08F222/22
Inventor 廖立琼邹雪晴邓鹏鹏
Owner WUHAN UNIV
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