Application of cinnamon polyphenol composition

The technology of a polyphenol composition and cinnamon, applied in the field of medicine, can solve the problems of limited viral diseases and the impact of vaccine clinical effects, and achieve the effects of strong drug efficacy, significant antiviral activity, and basically clear effects.

Active Publication Date: 2017-05-03
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most viral diseases have no specific drugs so far, and the viral diseases that can be prevented and treated by vaccines are also very limited
The mutation of the virus also affects the clinical effect of some vaccines to a certain extent

Method used

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  • Application of cinnamon polyphenol composition
  • Application of cinnamon polyphenol composition
  • Application of cinnamon polyphenol composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] Preparation of the standard curve: Accurately measure 1.0, 2.0, 3.0, 4.0, 5.0, 6.0 mL of the reference solution, put them in 25 mL brown measuring bottles, add 1 mL of phosphomolybdenum tungstic acid solution, and then add water 11, 10, 9, 8, 7, 6mL, dilute to the mark with 20% sodium carbonate solution, shake well, stand for 30min, use the corresponding reagent as a blank, measure the absorbance at 760nm, draw the standard curve with the absorbance as the ordinate and the concentration as the abscissa.

[0023] Total phenols: Accurately measure 2mL of the test solution, put it in a 25mL brown measuring bottle, follow the method under the preparation of the standard curve, start from "adding 1mL of phosphomolybdotungstic acid test solution", add 10mL of water, and measure the absorbance according to the law. Read the amount (mg) of gallic acid in the test solution in the standard curve, calculate, and get final product.

[0024] Polyphenols that are not adsorbed: Accura...

Embodiment 1

[0049] Preparation of cinnamon polyphenol composition

[0050] Preparation of cinnamon polyphenol composition 1: crush cinnamon bark, soak in 10 times the amount of water, and extract at room temperature for 3 times, 2 hours each time. Filtrate, take the filtrate, concentrate, add the concentrated solution into the acidic phosphate buffer solution with pH 6, adjust the pH value to 3 with hydrochloric acid, and let stand. The precipitated part was taken to obtain cinnamon polyphenol composition 1.

[0051] Preparation of cinnamon polyphenol compositions 2-12: take Daye Qinghuagui, Ceylon cinnamon, Huanangui, Blunt-leaf osmanthus, Yinxiang, Tianzhugui, Yinyegui, Xianggui, Chaigui and Chuangui respectively. The bark and cinnamon branches are crushed, soaked in 10 times the amount of water at room temperature and extracted 3 times, 2 hours each time. Filtrate, take the filtrate, concentrate, add the concentrated solution into the acidic phosphate buffer solution with pH 6, adjus...

Embodiment 2

[0060] Determination of total tannin content of cinnamon polyphenol composition

[0061] 1. Experimental materials

[0062] Instruments: UV-2450 UV-Vis Spectrophotometer (Shimadzu Corporation, Japan); 5510E-DTH Ultrasonic Apparatus (Branson Corporation, USA); Milli-Q Ultrapure Water Machine (Millipore Corporation); SW22 Constant Temperature Oscillator (U.S. Bo company); CP225D electronic analytical balance (Sartorius company).

[0063] Reagent: sodium tungstate (analytical grade, Shanghai Macklin Biochemical Technology Co., Ltd.), sodium molybdate (analytical grade, Shanghai Macklin Biochemical Technology Co., Ltd.), lithium sulfate (analytical grade, Shanghai Aladdin Biochemical Technology Co., Ltd.) , sodium carbonate (analytical pure, Tianjin Fengchuan Chemical Reagent Technology Co., Ltd.), hydrochloric acid (analytical pure, Tianjin Fengchuan Chemical Reagent Technology Co., Ltd.), phosphoric acid (analytical pure, Guangdong Guanghua Chemical Factory Co., Ltd.); casein (...

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Abstract

The invention discloses application of a cinnamon polyphenol composition. The cinnamon polyphenol composition can be applied to preparation of drugs and/or medical instruments for prevention and/or treatment of virus infection diseases. The invention discloses antiviral activity of the cinnamon polyphenol composition. Based on an intermediate infrared spectrum fingerprint and total tannin and total sugar content determination technology, a quality control method of the cinnamon polyphenol composition is established. Study confirms that the cinnamon polyphenol composition meeting the quality control requirement of the invention has significant antiviral activity. The cinnamon polyphenol composition provided by the invention has the characteristics of basically clear pharmacodynamic substances, controllable quality and stronger efficacy, and adapts to the process technology and quality standardization requirements of modern manufacturing industry.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of a cinnamon polyphenol composition. Background technique [0002] Viruses are important pathogens of humans and animals. According to statistics, more than 80% of infectious diseases are caused by viruses. Many noncommunicable diseases are also associated with viral infections. At present, the prevention and treatment of viral infectious diseases is mainly based on the application of antiviral drugs and specific vaccines. However, there are still no specific drugs for most viral diseases, and the viral diseases that can be prevented and treated by vaccines are also very limited. The mutation of the virus also affects the clinical effect of some vaccines to a certain extent. So far, viral diseases are still a difficult class of diseases in the medical field. Chinese medicine shows certain advantages to the treatment of certain viral diseases (su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P31/14A61P31/16A61P31/22A61K129/00
CPCA61K36/54A61K2236/17A61K2236/331
Inventor 李宁张建文任超李丛茜普俊学杨兆祥
Owner KPC PHARM INC
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