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A kind of fluticasone propionate quantitative inhalation aerosol

A technology of fluticasone propionate and flutica propionate, applied in inhalers, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of contaminated liquid medicine, hidden dangers, high price of storage tanks, etc., and it is not easy to achieve Drug particles, the effect of not easily adsorbed

Active Publication Date: 2020-01-07
SICHUAN PURITY PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that the container affects the curative effect of the drug in the above-mentioned prior art, the proposed solution has brought other technical problems. For example, in the above-mentioned prior art, the use of low-boiling point aliphatic hydrocarbons to process fluticasone powder has a relatively large Potential safety hazards; the inner surface of the storage tank lined with fluorocarbon polymer is expensive, and at the same time, chemical substances in the coating, such as unpolymerized fluorocarbons, and residual catalysts may enter the liquid medicine, thereby contaminating the liquid medicine

Method used

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  • A kind of fluticasone propionate quantitative inhalation aerosol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Such as figure 1 Shown, a kind of fluticasone propionate metered inhalation aerosol, comprises aerosol preparation and the pressurized metered-dose inhaler that is used to contain this preparation, and described aerosol preparation comprises the active ingredient that is used for treating asthma or COPD and as described The liquefied propellant of the active ingredient solvent, the pressurized metered-dose inhaler includes a storage tank 1, a metering valve 2 and a driver 3, the material of the storage tank 1 is magnesium-aluminum alloy, and part of the inner surface of the storage tank 1 Or the entire inner surface is anodized, and the active ingredient is fluticasone propionate.

[0028] Specifically, the container 1 is used as a container for the aerosol preparation in the pressurized metered-dose inhaler. By setting the material of the container 1 as magnesium-aluminum alloy, the inner surface of the container 1 is partially or The entire surface is anodized, so th...

Embodiment 2

[0041] This embodiment is further limited on the basis of Example 1. In order to improve the therapeutic effect of the aerosol preparation, the fluticasone propionate is the micropowder obtained by air-pulverizing the bulk drug of fluticasone propionate. Further, the particle size of the above micropowder is between 2-4.5 microns, so that not only the surface of the storage tank 1 has less adsorption of the active ingredient, but also the active ingredient in the aerosol preparation can be effectively deposited in the lungs or on the trachea, thereby facilitating the improvement of the therapeutic effect of the aerosol.

[0042] In order to facilitate the proportioning of the aerosol while meeting the curative effect requirements, the content of the fluticasone propionate in the aerosol preparation is 0.05-0.43wt%.

[0043] In order to make the aerosol in the long-term storage process, the surface of the storage tank 1 has a very weak adsorption amount of active ingredients in...

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Abstract

The invention discloses a fluticasone propionate aerosol realizing quantitative inhalation. The fluticasone propionate aerosol realizing quantitative inhalation comprises an aerosol preparation and a pressurized metered dose inhaler used for accommodating the preparation, wherein the aerosol preparation comprises an active ingredient used for treating asthma or COPD and a liquefied propellant taken as a solvent of the active ingredient, the pressurized metered dose inhaler comprise an accommodating tank, a metering valve and a driver, the accommodating tank is made of magnesium-aluminum alloy, part of the inner surface or the whole inner surface of the accommodating tank is subjected to anodizing treatment, and the active ingredient is fluticasone propionate. The aerosol is low in production cost, and the curative effects of the active ingredient of the fluticasone propionate aerosol can be effectively kept.

Description

technical field [0001] The invention relates to the field of medical aerosol products, in particular to a fluticasone propionate quantitative inhalation aerosol. Background technique [0002] Currently, pressurized metered-dose inhalers (MDIs) are the most effective and accepted means for precise delivery of small doses to the human respiratory tract. Therapeutic agents typically delivered by this means include bronchodilators of beta2 adrenergic agonists, particularly beta2 agonists and corticosteroids, and combinations thereof. Typical MDIs include a pressure-resistant tank filled with therapeutic agents, most of which are drugs dissolved in liquefied propellants or micronized particles suspended in liquefied propellants. MDIs are also equipped with metering valves, which can be measured by touching valve to release a quantity of therapeutic agent. [0003] According to the anatomical and physiological structure of the bronchial bronchioles and the lungs, in order to eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M15/00A61K9/00A61K31/56
CPCA61K9/008A61K31/56A61M15/0028A61M15/0065
Inventor 舒宏侯曙光李丛菊杨丽吴君
Owner SICHUAN PURITY PHARM CO LTD