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A kind of preparation method of antibacterial veterinary drug quinocetone

A technology of quinocetone and acetone, applied in the field of veterinary medicine, can solve the problems of unstable catalyst sodium n-butoxide, difficult to large-scale industrial production, corrosiveness and toxicity, etc., and achieves the advantages of overcoming unstable catalyst, avoiding pollution and short reaction time. Effect

Active Publication Date: 2020-01-31
杭州洪桥中科基因技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process steps are short, but the reaction mixture must be aged and crystallized overnight, the reaction time is long, and the catalyst sodium n-butoxide used is unstable, corrosive and toxic, and the reaction yield is low, which can only reach 57%, which is difficult to scale up. Large-scale industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-2

[0019] Preparation of alkaline ionic liquid:

[0020] Reflux of N-methylimidazole with excess chloro-n-butane in toluene for 48 hours affords the chloride salt of 1-butyl-3-methylimidazole. Use this chloride salt to separate with NH 4 OH, NH 4 HCO 3 After carrying out ion exchange reaction in acetonitrile solution, filter, remove solvent, and vacuum dry to obtain corresponding basic ionic liquid 1 and basic ionic liquid 2, respectively, as shown in the following formula:

[0021] , .

Embodiment 3

[0023] Reflux of N-methylpyrrole with excess chloro-n-butane in toluene for 48 hours affords the chloride salt of 1-butyl-1-methylpyrrole. Use this chloride salt with NH 4 HCO 3 After carrying out the ion exchange reaction in the acetonitrile solution, filter, remove the solvent, and vacuum dry to obtain the corresponding basic ionic liquid 3 respectively, as shown in the following formula:

[0024] .

Embodiment 4

[0026] Reflux of N-methylpiperidine with excess chloro-n-butane in toluene for 48 hours gave 1-butyl-1-methylpiperidine as the chloride salt. Use this chloride salt with NH 4 HCO 3 After carrying out ion exchange reaction in acetonitrile solution, filter, remove solvent, and vacuum dry to obtain corresponding basic ionic liquid 4, as shown in the following formula:

[0027] .

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Abstract

The invention provides a preparation method of quinocetone which is a national first class new veterinary medicine initiated internationally and has antibacterial, diarrhea-stopping and growth-promoting effects. The preparation method comprises the following steps: adding alkaline ionic liquid into a reactor, adding benzofurazan and benzylidene acetylacetone, stirring, conducting reaction at room temperature, and performing aftertreatment on the reaction liquid after the reaction to obtain the quinocetone. The method is short in process step, mild in reaction condition, short in reaction time, high in efficiency, high in product yield and high in product purity; meanwhile, the alkaline ionic liquid provided by the invention is in a liquid state at room temperature, has high dissolubility on the raw materials and can serve as a catalyst and a reaction solvent of a reaction system, so that environmental pollution caused by an organic solvent is avoided and large-scale production is facilitated.

Description

technical field [0001] The invention relates to the field of veterinary drugs, in particular to a new green process for synthesizing quinocetone by one-step method of antibacterial, antidiarrheal, and growth-promoting veterinary drugs. Background technique [0002] The chemical name of quinocetone is 3-methyl-2-cinnamoyl quinoxaline-1,4-dioxide (MBQO for short), which is a national first-class new veterinary drug initiated by my country in the world. effect. By inhibiting the synthesis of bacterial DNA, inhibiting the growth and reproduction of pathogenic microorganisms in the digestive tract, preventing or reducing the occurrence of diseases, protecting the intestinal beneficial flora and intestinal wall from microorganisms or parasites, and promoting the digestion and absorption of various nutrients, thereby accelerating the Animal growth, improve feed conversion rate. Quinocetone can also be used in aquaculture to promote antibacterial growth, improve survival rate, clar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D241/52C07D233/58C07D207/323C07D295/037C07D295/023B01J31/02
CPCB01J31/0244C07D207/323C07D233/58C07D241/52C07D295/023C07D295/037
Inventor 杨芳王晗童夏霞黄磊周泉丽张宇舒建洪
Owner 杭州洪桥中科基因技术有限公司