Cell-biological scaffold complex and 3D printing forming method thereof

A bio-scaffold and 3D printing technology, applied in the biological field, can solve the problems of low compound efficiency of bio-scaffold and cells, easy loss of cells, long culture time, etc., to avoid cell loss or a large number of shedding, improve compound efficiency, and simple preparation process Effect

Inactive Publication Date: 2017-05-24
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Based on the technical problems existing in the background technology, the present invention proposes a cell-biological scaffold complex and its 3D printing forming method, whic

Method used

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Embodiment 1

[0018] This embodiment proposes a cell-bio-scaffold complex, including a bio-scaffold and a cell-biogel suspension disposed on the bio-scaffold, and the bio-scaffold includes a biopolymer material, a natural biomaterial, and an inorganic material or a combination of more, biopolymer materials include calcium phosphate, polycaprolactone, polytetrafluoroethylene and lactic acid-glycolic acid copolymer or a combination of more, natural biomaterials include one of gelatin and sodium alginate A combination of two or two, the inorganic material includes calcium sulfate, borosilicate and nano-hydroxyapatite, and the cell-biogel suspension includes cells and biogel liquid, and the cells It is osteoblast or corneal stromal cell, and the biogel solution includes 12 parts by weight of glacial acetic acid, 20 parts of chitosan, 10 parts of sodium hydroxide and 8 parts of triethanolamine.

[0019] This embodiment also proposes a 3D printing forming method of the cell-biological scaffold co...

Embodiment 2

[0025] This embodiment proposes a cell-bio-scaffold complex, including a bio-scaffold and a cell-biogel suspension disposed on the bio-scaffold, and the bio-scaffold includes a biopolymer material, a natural biomaterial, and an inorganic material or a combination of more, biopolymer materials include calcium phosphate, polycaprolactone, polytetrafluoroethylene and lactic acid-glycolic acid copolymer or a combination of more, natural biomaterials include one of gelatin and sodium alginate A combination of two or two, the inorganic material includes calcium sulfate, borosilicate and nano-hydroxyapatite, and the cell-biogel suspension includes cells and biogel liquid, and the cells It is osteoblast or corneal stromal cell, and the biogel liquid includes 16 parts by weight of glacial acetic acid, 25 parts of chitosan, 15 parts of sodium hydroxide and 12 parts of triethanolamine.

[0026] This embodiment also proposes a 3D printing forming method of the cell-biological scaffold com...

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PUM

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Abstract

The invention discloses a cell-biological scaffold complex and a 3D printing forming method thereof. The cell-biological scaffold complex comprises a biological scaffold and a cell-biological gel suspension arranged on the biological scaffold, wherein the biological scaffold comprises a one of or a combination of several of a biological macromolecular material, a natural biological material and an inorganic material, the biological macromolecular material comprises one of or a combination of several of calcium phosphate, polycaprolactone, polytetrafluoroethylene and lactic acid-hydroxyacetic acid copolymer, the natural biological material comprises one of or a combination of two of gelatin and sodium alginate, the inorganic material comprises one of or a combination of several of calcium sulfate, boron silicate and nano hydroxylapatite, the cell-biological gel suspension comprises cell and biological gel, and the cell is a bone cell or a corneal stroma. By adopting the cell-biological scaffold complex and the 3D printing forming method, a complexing efficiency of the cell and the biological gel suspension can be increased, the loss or dropping of a great amount of cells is avoided, the preparation process is simple, and the use is convenient.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a cell-biological scaffold complex and a 3D printing forming method thereof. Background technique [0002] Tissue defect repair and organ transplantation are one of the greatest breakthroughs in the history of medicine in the 20th century. At present, nearly one million patients in the world who were once shrouded in the shadow of death have obtained a new life through organ transplantation, but they cannot perform due to lack of donor organs. There are tens of millions of patients who die from organ transplantation, and hundreds of millions of patients who need tissue defect repair. Therefore, some people say that the 21st century is the century of tissue repair and organ transplantation. The emergence of 3D printing technology has made millions of people who need tissue repair Patients with prosthetics and organ transplants are given hope of healing and rebirth. [0003] The paten...

Claims

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Application Information

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IPC IPC(8): A61L27/38A61L27/42A61L27/48A61L27/50B29C64/112B33Y10/00
CPCA61L27/3821A61L27/3804A61L27/42A61L27/48A61L27/50B33Y10/00
Inventor 赵劲民郑立陆真慧吴洋杨星辰
Owner GUANGXI MEDICAL UNIVERSITY
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