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Changtongshu oral liquid and preparation method thereof

A technology of Changtongshu oral liquid and oral liquid, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc. Problems such as high content, to achieve the effect of improving bioavailability, facilitating dissolution and absorption, and high content

Inactive Publication Date: 2017-05-31
JIANGXI JIMINKEXIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dosage is boiled water, 6g each time, 2-3 times a day; however, Changtongshu granules are ordinary granules, made into granules, which are easy to agglomerate and mildew in high temperature and humid environment, so it is not suitable for long-term storage
Due to the simple preparation process, high impurity content and relatively many side reactions, it is only suitable for storage in the dry environment in the north

Method used

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  • Changtongshu oral liquid and preparation method thereof
  • Changtongshu oral liquid and preparation method thereof
  • Changtongshu oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] Experimental example 1: the choice of flavoring agent

[0030] The oral liquid of the present invention contains five medicinal materials of grades of Polygonum multiflorum multiflorum, Angelica sinensis and Radix paeoniae Rubra. As an oral preparation, the mouthfeel is important, and flavoring agents must be added to be accepted by people who need to take it. Commonly used flavoring agents in oral liquids include sucrose, honey, starch syrup, protein sugar, etc. At present, sucrose is the commonly used flavoring agent, because sucrose is sweet in taste and cold in nature, it has the effects of moistening lungs and promoting body fluid, harmonizing lungs, and soothing liver qi. Efficacy, according to the above situation, select sucrose to prepare as flavoring agent.

[0031] Table 1 The taste and quality of adding different amounts of sucrose

[0032]

[0033]

[0034] According to the above experimental situation, sucrose will not affect the quality of the prepa...

experiment example 2

[0036] Experimental example 2: Screening of preparation process

[0037] method one,

[0038] For the above five flavors, add 10 times the amount of water to decoct once, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.17 (80°C), wait to cool to room temperature, add an equal amount of ethanol, and stir well , stand still for 24 hours, take the supernatant and concentrate it into a clear paste with a relative density of 1.30 (80° C.) after recovering ethanol. Add 8 times the amount of water and sodium benzoate, stir well, let stand for 24 hours, take the supernatant and filter it with a stainless steel plate frame machine, add sucrose and ethylparaben to the filtrate, heat and boil for 30 minutes, let cool, add Adjust the total amount of purified water to 1000ml, let it cool, filter it with a stainless steel plate frame, fill it, sterilize it, and pack it to get it, 10ml / cartridge.

[0039] Method Two,

[0040] Fo...

Embodiment 1

[0051] Embodiment 1: oral liquid of the present invention

[0052]

[0053] Above-mentioned raw material is mixed with oral liquid 1000ml as follows;

[0054] For the above five flavors, add 8 times the amount of water to decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.17 (80°C), wait to cool to room temperature, add recovered ethanol to make the alcohol content reach 60%, stir evenly, stand still for 24 hours, take the supernatant and recover the ethanol thickness and concentrate it into a clear paste with a relative density of 1.30 (80°C). Add 8 times the amount of water and sodium benzoate, stir well, let stand for 24 hours, take the supernatant and filter it with a stainless steel plate frame machine, add sucrose and ethylparaben to the filtrate, heat and boil for 30 minutes, let cool, add Adjust the total amount of purified water to 1000ml, let it cool, filter it with a stainless steel plate fr...

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PUM

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Abstract

The invention belongs to the field of pharmacy, and particularly relates to Changtongshu oral liquid. The Changtongshu oral liquid is prepared from, by weight, 1,000-1,500 parts of radix polygoni multiflori, 700-800 parts of radix angelicae sinensis, 700-900 parts of radix paeoniae rubra, 700-900 parts of fructus cannabis, 700-900 parts of mulberries, 130-170 parts of sucrose, 1-7 parts of sodium benzoate and 0.1-0.7 part of ethylparaben.

Description

technical field [0001] The invention relates to an oral liquid, in particular to a Changtongshu oral liquid and a preparation method thereof. Background technique [0002] Changtongshu granules are granules made from the five medicinal materials of Polygonum multiflorum, Angelica, Radix Paeoniae Rubra, Hemp Seed, and Mulberry, plus appropriate amount of excipients. 3 -B-2031-95, has the functions of nourishing yin and nourishing blood, moistening intestines and laxative. For habitual constipation, senile constipation and postpartum constipation embolism. The usage and dosage are boiled water, 6g each time, 2-3 times a day; but Changtongshu Granules are ordinary granules, made into granules, which are easy to agglomerate and mildew in high temperature and humid environment, so it is not suitable for long-term storage. Due to the simple preparation process, high impurity content and relatively many side reactions, it is only suitable for storage in the dry environment in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/26A61K36/71A61K36/704A61P1/10
CPCA61K9/0053A61K9/08A61K36/232A61K36/60A61K36/605A61K36/65A61K36/704A61K36/71A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 彭启华郭伟余宣杨明何平清
Owner JIANGXI JIMINKEXIN PHARMA
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