Prussian blue analog nanoparticles, and preparation method and application thereof

Abstract

The invention discloses Prussian blue analog nanoparticles. The nanoparticles are formed by using Prussian blue analog nanoparticles as the core and coating organic high-polymer surface protectants polyvinylpyrrolidone / chitosan and hyaluronic acid on the nanoparticle surface. The preparation method of the Prussian blue analog nanoparticles comprises the following steps: S1. preparing a mixed solution containing a zinc salt, ferrous sulfate, an iron salt and an organic high-polymer surface protectant; S2. stirring at room temperature for 30 minutes to 2 hours, putting the solution into a dialysis bag filled with distilled water, and dialyzing for two days; and S3. taking out the solid matter, and collecting the solid product by freeze-drying. The Prussian blue analog nanoparticles are used in cancer targeted therapy. The Zn-FePB NPH drug is very safe. The copper element in cancer cells can be replaced to achieve the goal of starving the cancer cells. PVP (or chitosan) doping is carried out on the basis of the high targeting action of the hyaluronic acid to better regulate the size of the nanoparticles.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a Prussian blue-like nanoparticle and a preparation method and application thereof. Background technique [0002] Cancer is a general term for various malignant tumors and a major disease that threatens human health. Cancer is generally difficult to cure. Not only the patient has a lot of mental stress, but also the family has brought great mental and material pressure. Traditional treatments include surgery, radiation and chemotherapy. Traditional surgery can be used to remove early benign and non-spread tumors, but it may not be able to completely remove the tumor, and the tumor may recur; radiotherapy uses high-energy rays to kill the tumor to achieve the purpose of treating the tumor, and early treatment can kill the tumor. A large number of tumor cells, but a small number of mutated tumor cells can continue to survive and proliferate, eventually le...

AI Technical Summary

Problems solved by technology

Traditional surgery can be used to remove early benign and non-spread tumors, but it may not be able to completely remove the tumor, and the tumor may recur; radiotherapy uses high-energy rays to kill the tumor to achieve the purpose of treating the tumor, and early treatment can kill the tumor. A large number of tumor cells, but a small number of mutated tumor cells can continue to survive and proliferate, eventually leading to the failure of radiotherapy; chemotherapy is to kill or inhibit the growth and proliferation of tumor cells with chemical drugs, but long-term chemotherapy will cause serious resistance to tumor cells. drug properties, so that the desired effect cannot be achieved

Although radiotherapy and chemotherapy kill tumor cells to a certain extent, they also cause damage to normal cells in the human body and cause side effects in the human body

[0003] For traditional cancer drugs, the phagocytes in the human immune system tend to swallow them, making the drugs ineffective

Moreover, the molecular size of traditional drugs is relatively large and cannot reach the inside of the cell.

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