Preparation method for temperature-sensitive fine particle surface-grafted cross-linked complex gel
A technology of surface grafting and composite gel is applied in the field of preparation of temperature-sensitive microsphere surface grafting and cross-linked composite gel, which can solve the problems of complicated operation, low product purity, poor toughness and the like, and achieves simple operation and high product quality. The effect of high purity and good mechanical properties
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Embodiment 1
[0017] The preparation method of temperature-sensitive type microsphere surface graft cross-linked composite gel comprises the following steps:
[0018] (1) Preparation of microparticles:
[0019] Dissolve 15g of N-vinylformamide in 500mL of aqueous solution, heat to 70°C, and then add 1g of azobisisobutylamidine hydrochloride to initiate aqueous polymerization to obtain polymerized N-vinylformamide. After adding 200mL of 1mol / L NaOH solution, react at 90°C for 3 hours to generate polyvinylamine, add 0.68g N'-isopropylacrylamide, 0.43g butyl methacrylate and 0.28g polyvinylamine in sequence, add 100mL water, adjust the pH of the solution Adjust the value to 7~8, pass N 2 After 30 minutes, add 0.60 g of tert-butyl hydroperoxide aqueous solution with a mass fraction of 0.1%, stir and react in a heating oil bath at 70°C for 6 hours, and naturally cool to room temperature after the reaction to obtain a microparticle emulsion;
[0020] (2) Preparation of composite hydrogel:
[...
Embodiment 2
[0023] The preparation method of temperature-sensitive type microsphere surface graft cross-linked composite gel comprises the following steps:
[0024] (1) Preparation of microparticles:
[0025] Dissolve 15g of N-vinylformamide in 500mL of aqueous solution, heat to 70°C, and then add 1g of azobisisobutylamidine hydrochloride to initiate aqueous polymerization to obtain polymerized N-vinylformamide. After adding 200mL of 1mol / L NaOH solution, react at 90°C for 3 hours to generate polyvinylamine, add 0.68g N'-isopropylacrylamide, 0.43g butyl methacrylate and 0.28g polyvinylamine in sequence, add 100mL water, adjust the pH of the solution Adjust the value to 7~8, pass N 2 After 30 minutes, add 0.60 g of tert-butyl hydroperoxide aqueous solution with a mass fraction of 0.1%, stir and react in a heating oil bath at 70°C for 6 hours, and naturally cool to room temperature after the reaction to obtain a microparticle emulsion;
[0026] (2) Preparation of composite hydrogel:
[...
Embodiment 3
[0029] The preparation method of temperature-sensitive type microsphere surface graft cross-linked composite gel comprises the following steps:
[0030] (1) Preparation of microparticles:
[0031] Dissolve 15g of N-vinylformamide in 500mL of aqueous solution, heat to 70°C, and then add 1g of azobisisobutylamidine hydrochloride to initiate aqueous polymerization to obtain polymerized N-vinylformamide. After adding 200mL of 1mol / L NaOH solution, react at 90°C for 3 hours to generate polyvinylamine, add 0.68g N'-isopropylacrylamide, 0.43g butyl methacrylate and 0.28g polyvinylamine in sequence, add 100mL water, adjust the pH of the solution Adjust the value to 7~8, pass N 2 After 30 min, where, N 2 The flow rate is 10mL / min, add 0.60 g of tert-butyl hydroperoxide aqueous solution with a mass fraction of 0.1%, stir and react in a heating oil bath at 70°C for 6 hours, wherein the stirring speed is 250 rpm, and naturally cool to At room temperature, microparticle emulsion is ob...
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