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Polyamide-amine dendritic polymer modified by polypeptide and its preparation method and application

A technology of polypeptide modification and polyamide, which is applied in the field of biomineral interface adhesion materials, can solve the problem of single function, and achieve the effect of firm adsorption, rich functions, and easy industrial production

Active Publication Date: 2020-08-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned modified polyamidoamine dendrimers have only been confirmed to have an adsorption effect on hydroxyapatite, and the function is relatively single. Therefore, if a modified polyamidoamine with more functions can be developed Dendritic polymers, such as modified polyamide-amine dendrimers that can be used in the fields of biomineralization, protein crystallization, and tissue engineering scaffold materials, are useful for expanding polyamide-amine dendrimers The application field of things will have positive significance

Method used

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  • Polyamide-amine dendritic polymer modified by polypeptide and its preparation method and application
  • Polyamide-amine dendritic polymer modified by polypeptide and its preparation method and application
  • Polyamide-amine dendritic polymer modified by polypeptide and its preparation method and application

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Experimental program
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Embodiment 1

[0052] In this embodiment, the preparation method of polyamide-amine type dendritic polymer modified by polypeptide is provided, and its synthetic route is as follows figure 1 As shown, the steps are as follows:

[0053] (1) Synthesis of polyamide-amine dendrimers whose end groups are acryloyl groups

[0054] ① Prepare the first solution

[0055] At room temperature and under normal pressure, 6.9g of polyamide-amine dendrimers (G4PAMAM) whose 4th generation terminal group is amino are dissolved in 4mL of anhydrous dimethyl sulfoxide to form the first solution; the first The concentration of G4PAMAM in the solution is 1.725g / mL;

[0056] ② Prepare the second solution

[0057] Under room temperature, normal pressure condition, triethylamine (TEA) is dissolved in the first kind of solution to form the second kind of solution; The mol ratio of described triethylamine and the amino group of G4PAMAM in the first kind of solution is 1.1:1;

[0058] ③Synthesis

[0059] Add acrylo...

Embodiment 2

[0073] In this embodiment, the preparation method of polyamide-amine type dendritic polymer modified by polypeptide is provided, and its synthetic route is as follows figure 1 As shown, the steps are as follows:

[0074] (1) Synthesis of polyamide-amine dendrimers whose end groups are acryloyl groups

[0075] ① Prepare the first solution

[0076] At room temperature and normal pressure, 5.17g of polyamide-amine dendrimers (G1PAMAM) whose terminal groups are amino groups are dissolved in 5.17mL of anhydrous dimethyl sulfoxide to form the first solution; The concentration of G1PAMAM in a solution is 1g / mL;

[0077] ② Prepare the second solution

[0078] Under room temperature, normal pressure condition, triethylamine is dissolved in the first kind of solution to form the second kind of solution; The mol ratio of described triethylamine and the amino group of G1PAMAM in the first kind of solution is 1.1:1;

[0079] ③Synthesis

[0080] Add acryloyl chloride dropwise to the se...

Embodiment 3

[0094] In this embodiment, the preparation method of polyamide-amine type dendritic polymer modified by polypeptide is provided, and its synthetic route is as follows figure 1 As shown, the steps are as follows:

[0095] (1) Synthesis of polyamide-amine dendrimers whose end groups are acryloyl groups

[0096] ① Prepare the first solution

[0097] At room temperature and normal pressure, 1.4g of polyamide-amine dendrimers (G2PAMAM) whose terminal groups are amino groups are dissolved in 1.4mL of anhydrous dimethyl sulfoxide to form the first solution; The concentration of G2PAMAM in a solution is 1g / mL;

[0098] ② Prepare the second solution

[0099] Dissolve triethylamine in the first solution at room temperature and normal pressure to form a second solution; the molar ratio of triethylamine to the amino group of G2PAMAM in the first solution is 1:1;

[0100] ③Synthesis

[0101] Add acryloyl chloride dropwise to the second solution under the condition of ice-water bath an...

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Abstract

The invention provides a polypeptide modified polyamidoamine dendritic polymer. A structural formula of the dendritic polymer is shown as following as shown in the specification, wherein n is algebra of the polypeptide modified polyamidoamine dendritic polymer and is a positive integer between 1 and 9. The invention further provides a preparation method and an application of the polypeptide modified polyamidoamine dendritic polymer. Experiments show that the polypeptide modified polyamidoamine dendritic polymer has firm adsorption for biominerals such as hydroxyapatite, calcium phosphate and calcium carbonate and can perform adsorption film formation on the surfaces of the biominerals; and the surfaces of the biominerals wrapped with the polypeptide modified polyamidoamine dendritic polymer are further grafted with functional groups such as perfluoro acyl chloride and collagen to form a novel surface functional coating material for a biomineral material. The polymer has wide application prospects in the fields of biomineralization, protein crystallization, surface stamp / self-cleaning / anti-soil / antibiosis materials and tissue engineering scaffold materials.

Description

technical field [0001] The invention belongs to the field of biomineral interface adhesion materials, in particular to polyamide-amine dendritic polymers modified by polypeptides and their preparation methods and applications. Background technique [0002] Polyamide-amine dendrimers (PAMAM) are currently one of the most extensively and deeply researched dendrimers. At present, carboxylate, alendronic acid, and phosphate are used to modify polyamide-amine dendrimers. And it was verified that the modified polyamide-amine dendritic polymer has adsorption effect on hydroxyapatite. For example, CN 102166160 B discloses the application of carboxyl-modified polyamide-amine dendrimers as dentin remineralization inducers, and CN 103342819 B discloses polyamide-amine dendrimers whose terminal groups are phosphate groups , its preparation method and its application as an in situ remineralization inducer for preparation of dentin and enamel. However, the above-mentioned modified polya...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00
CPCC08G83/004
Inventor 李建树杨潇丁春梅
Owner SICHUAN UNIV
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