Ultralow-frequency-magnetic-field-sensitive functional magnetic nano material and preparation method thereof

A magnetic nanometer and ultra-low frequency technology, applied in the field of nanomedicine, can solve the problems of unsatisfactory curative effect of deep tumors in the body, expensive anticancer treatment, and impact on human health, and achieve the effect of avoiding adverse effects, simple structure, and low cost

Inactive Publication Date: 2017-06-06
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These two treatment methods have the following defects: magnetic nanomaterials are used as anti-cancer drug carriers. Although the effect of targeted therapy can be improved under the action of an external magnetic field, the anti-cancer treatment is expensive and has large side effects. It will still affect normal cells, thereby affecting human health; magnetothermal therapy is to use an external magnetic field to directly heat. The working frequency of the magnetic field ranges from a few megahertz to several gigahertz, and the power consumption is usually between 300 watts and 500 watts. Therefore, healthy tissues around the tumor will also absorb electromagnetic energy and be damaged, and this method is still not effective for deep tumors in the body. ideal
However, the existing studies all use micron-scale "magnetic knife" to produce mechanical damage to tumor cells in an alternating magnetic field, resulting in the death of cancer cells
Due to the large size of the micron-scale "magnetic knife", it is not easy to be swallowed by cells, and it is easy to block blood vessels during the circulation process in the body, especially in the process of brain tumor treatment, because of its large size, it is difficult to cross the blood-brain barrier, which is serious. affected the therapeutic effect

Method used

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  • Ultralow-frequency-magnetic-field-sensitive functional magnetic nano material and preparation method thereof
  • Ultralow-frequency-magnetic-field-sensitive functional magnetic nano material and preparation method thereof
  • Ultralow-frequency-magnetic-field-sensitive functional magnetic nano material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A functional magnetic nanomaterial sensitive to an ultra-low frequency magnetic field, the preparation method of which is as follows:

[0052] (1) Preparation of magnetic nanomaterials:

[0053] (1) Zinc acetylacetonate and iron acetylacetonate are added to a 50mL three-necked flask at a molar ratio of 3:2;

[0054] (2) adding oleic acid and dibenzyl ether;

[0055] (3) feed protective gas, and stir until the solid is completely dispersed in oleic acid and dibenzyl ether;

[0056] (4) Heating to 290°C and reacting for 30 minutes;

[0057] (5) After the reaction finishes, wait for the temperature to drop to room temperature, and add dehydrated alcohol to the reaction system;

[0058] (6) After standing overnight, a black solid precipitate appeared, and the solid precipitate was washed several times with ethanol and toluene, and then dispersed in toluene to obtain a magnetic nanomaterial.

[0059] (2) Preparation of functional magnetic nanomaterials:

[0060] (1) Dis...

Embodiment 2

[0074] A functional magnetic nanomaterial sensitive to an ultra-low frequency magnetic field, the preparation method of which specifically includes the following steps:

[0075] (1) Preparation of magnetic nanomaterials:

[0076] (1-1) Add zinc acetylacetonate and iron acetylacetonate weighed at a molar ratio of 3:1 to the mixture of oleic acid and dibenzyl ether, so that for every 1 mL of the mixture of oleic acid and dibenzyl ether, add 20 mg of acetyl Zinc acetone, followed by argon as a protective gas, stirred until uniformly mixed, wherein the volume ratio of oleic acid to dibenzyl ether was 1:10;

[0077] (1-2) react at 280° C. for 35 minutes, add absolute ethanol after cooling, wherein, the volume ratio of absolute ethanol to the mixture of oleic acid and dibenzyl ether in step (1-1) is 1:4;

[0078] (1-3) A solid precipitate was obtained after standing for 4 hours. After the solid precipitate was washed with ethanol, it was dispersed in toluene, and 8 mg of the solid ...

Embodiment 3

[0085] A functional magnetic nanomaterial sensitive to an ultra-low frequency magnetic field, the preparation method of which specifically includes the following steps:

[0086] (1) Preparation of magnetic nanomaterials:

[0087] (1-1) Add zinc acetylacetonate and iron acetylacetonate weighed at a molar ratio of 3:3 to the mixture of oleic acid and dibenzyl ether, so that for every 1 mL of the mixture of oleic acid and dibenzyl ether, add 30 mg of acetyl Zinc acetone, followed by argon as a protective gas, stirred until uniformly mixed, wherein the volume ratio of oleic acid to dibenzyl ether was 2:10;

[0088] (1-2) react at 300° C. for 25 minutes, add absolute ethanol after cooling, wherein, the volume ratio of absolute ethanol to the mixture of oleic acid and dibenzyl ether in step (1-1) is 1:6;

[0089] (1-3) After standing still for 12 hours, a solid precipitate was obtained. After the solid precipitate was washed with toluene, it was dispersed in toluene, and 12 mg of s...

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Abstract

The invention relates to an ultralow-frequency-magnetic-field-sensitive functional magnetic nano material and a preparation method thereof. The preparation method of the functional magnetic nano material comprises the following steps: (1) preparing a magnetic nano material from zinc acetylacetonate and iron acetylacetonate; and (2) improving the water solubility of the prepared magnetic nano material, and modifying targeting groups onto the surface of the water-soluble magnetic nano material, thereby obtaining the functional magnetic nano material. Compared with the prior art, the functional magnetic nano material is sensitive to the ultralow-frequency rotating magnetic field, and can avoid the adverse effects of the high-frequency magnetic field on the human body. After being modified by the targeting groups, the functional magnetic nano material has the function of targeting tumor cells, and can kill the tumor cell safely and effectively under the action of the ultralow-frequency magnetic field. The type of the targeting groups can be changed to implement accurate treatment on different cancer cells and tumor tissues, and the treatment process is safe and effective.

Description

technical field [0001] The invention belongs to the technical field of nanomedicine, and relates to a functional magnetic nanometer material sensitive to an ultra-low frequency magnetic field and a preparation method thereof. Background technique [0002] In recent years, magnetic nanomaterials have been used in various fields due to their unique magnetic properties and good biocompatibility, such as nuclear magnetic resonance imaging, gene or drug carriers, etc. Magnetic nanomaterials are regarded as Most Promising Nanomedicines. Especially in the treatment of brain tumors, magnetic nanomaterials modified by polypeptides have the ability to cross the blood-brain barrier, and the efficiency of crossing the blood-brain barrier can be enhanced by applying an external magnetic field. [0003] At present, there are two main ways to apply magnetic nanomaterials in tumor treatment: one is as a carrier of anticancer drugs or genes, which are targeted to the tumor site under the ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/32A61K47/42A61P35/00
CPCA61K41/0052A61K47/32A61K47/42
Inventor 成昱申雅静
Owner TONGJI UNIV
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