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Azobenzene derivative as well as preparation method and application thereof

A technology of azobenzene derivatives and reaction, applied in the field of azobenzene derivatives and its preparation, to achieve the effects of reducing side effects, simple preparation method, and improving therapeutic effect

Inactive Publication Date: 2017-06-06
E TECHNO INFORMATION TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the transportation of therapeutic drug macromolecules is still facing great challenges, because the drug delivery system we need should be able to achieve timed, fixed-point and quantitative release of drugs

Method used

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  • Azobenzene derivative as well as preparation method and application thereof
  • Azobenzene derivative as well as preparation method and application thereof
  • Azobenzene derivative as well as preparation method and application thereof

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preparation example Construction

[0100] In the first specific preparation embodiment of the present invention, the structural formula of the azobenzene derivative is as figure 1 As shown, the preparation method of the azobenzene derivative includes the following steps:

[0101] S01. Make compound 1 (4-methyl-4' hydroxyazobenzene) and compound 2 (n-tetradecanoic acid) undergo a lipidation reaction under the catalysis and heating of concentrated sulfuric acid to generate compound 3 (4-methyl -4'Azophenyl n-tetradecanoate);

[0102] S02. Dissolve 4-methyl-4'-tetradecanoic acid azophenyl ester, N-bromosuccinimide and benzoyl peroxide in tetrachloromethane under argon atmosphere, and heat and reflux for reaction for 24 hours ;

[0103] S03. Cool the reaction system of step S02 to 0°C, and filter with suction to obtain powder;

[0104] S04. Wash the powder obtained in step S03 with ether to remove unreacted impurities to obtain compound 4 (4-bromomethyl-4'-tetradecanoic acid azophenyl ester);

[0105] S05. Dissolve 4-bromo...

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Abstract

The invention relates to the field of stimulation-responsive carriers and provides an azobenzene derivative as well as a preparation method and application thereof. According to the azobenzene derivative, hydrophilic cation quaternary ammonium salt groups and long-chain hydrophobic alkyl are respectively linked to two ends of azobenzene, so that reversible conformation change can be generated under the radiation of ultraviolet light; MNPs responding to photostimulation can be prepared based on the azobenzene derivative, and when drugs are internally incorporated in the MNPs, the controllable release of the drugs can be realized, so that the side effect of the drugs can be reduced, and the treatment effect is improved. The preparation method of the azobenzene derivative is simple, and the yield is high.

Description

Technical field [0001] The invention relates to the field of stimulus response carriers, in particular to an azobenzene derivative and a preparation method and application thereof. Background technique [0002] Breakthroughs in nanotechnology have had an important impact on many industries, especially materials science, biotechnology, and drug therapy. Different nanocarriers, such as liposomes, polymers, micelles, and carbon-based nanomaterials are gradually being applied to the medical field, such as the transportation of therapeutic drug macromolecules (drugs and genes). However, the current transportation of therapeutic drug macromolecules still faces great challenges, because the drug delivery system we need is best able to achieve the timing, fixed-point and quantitative release of drugs. For the drug delivery system, there have been certain researches, for example: through intelligent micro / nano particles (MNPs). The MNPs refer to the general term of micro / nano particles ...

Claims

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Application Information

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IPC IPC(8): C07C245/08A61K9/127A61K47/18
CPCA61K9/1271A61K47/186C07C245/08
Inventor 张贯京耿胜勇葛新科高伟明徐之艳
Owner E TECHNO INFORMATION TECH
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