Manufacturing method of itraconazole drug membrane

Abstract

The invention relates to a drug for treating anabrosis induced by bacteria and in particular relates to a manufacturing method of an itraconazole drug membrane. The membrane comprises a membrane A and a membrane B, wherein the membrane A is prepared from the following components in parts: 100-150 parts of polyvinyl alcohol, the degree of polymerization of which is 2000, 400-600 parts of water, 10-20 parts of sucrose fatty acid ester, 1-2 parts of itraconazole, 50-80 parts of cyclodextrin or derivatives thereof, 10-20 parts of lecithin, 100-150 parts of pregelatinized starch and 15-25 parts of sodium alginate; and the membrane B is prepared from the following components in parts: 100-150 parts of polyvinyl alcohol, the degree of polymerization of which is 2000, 400-600 parts of water, 15-35 parts of a phosphoric acid slow release solution, the pH value of which is 5-5.5, 50-80 parts of cyclodextrin or derivatives thereof, 5-10 parts of chitosan, 100-180 parts of pregelatinized starch, 15-25 parts of sodium alginate and 5-10 parts of lecithin. By adhering the membranes A and B and adhering the membrane A containing the itraconazole component to an anabrosis part infected by bacteria, the itraconazole component in the membrane A reacts with an acidic component in the membrane B, so that the absorption efficiency of the drug is increased.

Description

technical field [0001] The invention relates to medicines for treating ulcers caused by bacteria, in particular to a preparation method of itraconazole drug film. Background technique [0002] The internal environment of the human body is not sterile. When the tissues of the human body are scratched, cut, etc., the skin or mucous membrane surface tissue is damaged, it will be more likely to be infected by bacteria, resulting in ulcers. [0003] For tissue damage on the surface of the skin, we can treat the wound with bactericidal solution, apply ointment, and stick bactericidal tape to prevent bacterial infection of the wound; but for bacterial tissue ulcers in the internal environment of the human body, such as fungal keratitis, Bacterial ulcer symptoms such as oral candidiasis and vulvovaginal candidiasis are difficult to heal internal ulcers because some drugs are highly irritating, or are not suitable for oral administration, or cannot be in contact with the wound for a ...

AI Technical Summary

Problems solved by technology

[0005] At present, itraconazole is often used to make capsules. It is administered orally and is absorbed in the acidic environment of the stomach. After absorption, itraconazole needs to reach the wound site through blood circulation to inhibit bacteria. effect, it needs to increase the dose to obtain good results; because itraconazole has extremely low solubility in aqueous media, it is difficult to prepare oral liquid preparations, and for the administration of ulcer tissues in the oral cavity and throat , it is difficult to make the drug attach to the wound effectively, so that the wound can continue to receive effective drug treatment