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Pharmaceutical composition of acetaminophen and glycyrrhizic acid or salt thereof or derivative thereof

A technology of acetaminophen and glycyrrhizic acid, which is applied in drug combinations, antipyretics, and pharmaceutical formulations, can solve problems such as lipid peroxidation, liver cell damage, and unreported issues, so as to ensure convenience and realize The effect of social benefits and considerable economic benefits

Pending Publication Date: 2017-06-09
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3. Drug metabolism produces superoxide ions to promote lipid peroxidation, leading to liver cell damage, etc.
However, most of the existing licorice extract preparations are used clinically in the form of single drug preparations, and there are few compound preparations. The compound preparations in use also use similar drugs with similar effects to form a compound to obtain drug synergy to enhance the curative effect
[0010] So far, there have been no relevant reports on the composition of acetaminophen and glycyrrhizic acid or glycyrrhizinate or glycyrrhizic acid derivatives

Method used

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  • Pharmaceutical composition of acetaminophen and glycyrrhizic acid or salt thereof or derivative thereof
  • Pharmaceutical composition of acetaminophen and glycyrrhizic acid or salt thereof or derivative thereof
  • Pharmaceutical composition of acetaminophen and glycyrrhizic acid or salt thereof or derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Hepatotoxicity Test of SD Rats by Repeated Oral Gavage of Different Doses of Acetaminophen

[0043] The purpose of this experiment is to explore the hepatotoxicity of different doses of acetaminophen given to SD rats by intragastric administration repeatedly, and to provide a suitable reference for the hepatotoxicity reduction test of the pharmaceutical composition composed of the drug and glycyrrhizic acid or its salt or its derivatives. Acetaminophen dose design basis.

[0044] The reagents used in this test are as follows:

[0045] 1. Acetaminophen, provided by: Beijing Kexinbicheng Pharmaceutical Technology Development Co., Ltd., batch number: 1311379, traits and physical and chemical properties: white crystal or crystalline powder.

[0046] 2. Carboxymethylcellulose sodium (CMC-Na), production unit: Sinopharm Chemical Reagent Co., Ltd., batch number: F20110523, properties and physical and chemical properties: white or yellowish fibrous powder, viscosity:...

Embodiment 2

[0092]Example 2 The preventive effect of the pharmaceutical composition of different ratios of acetaminophen and diammonium glycyrrhizinate on drug-induced liver injury

[0093] The purpose of this experiment is to explore the hepatotoxicity relief of SD rats by repeated intragastric administration of a pharmaceutical composition composed of acetaminophen (preparation A) and diammonium glycyrrhizinate (preparation B) in different proportions, and to determine the effect of the pharmaceutical composition on The preventive effect of drug-induced liver injury provides a basis for the design of dosage ratios for the subsequent research and development of the pharmaceutical composition.

[0094] The reagents used in this test are as follows:

[0095] 1. Acetaminophen, provided by: Beijing Kexinbicheng Pharmaceutical Technology Development Co., Ltd., batch number: 1311379, traits and physical and chemical properties: white crystal or crystalline powder.

[0096] 2. Diammonium glycy...

Embodiment 3

[0145] Example 3 The preventive effect of the pharmaceutical composition of different ratios of acetaminophen and monoammonium glycyrrhizinate on drug-induced liver injury

[0146] The purpose of this experiment is to explore the reduction of hepatotoxicity of SD rats by repeated intragastric administration of a pharmaceutical composition composed of acetaminophen (preparation A) and monoammonium glycyrrhizinate (preparation B) in different proportions, and to determine whether the pharmaceutical composition The preventive effect on drug-induced liver injury provides a basis for dosage ratio design for the subsequent research and development of the pharmaceutical composition.

[0147] The reagents used in this test are as follows:

[0148] 1. Acetaminophen, provided by: Beijing Kexinbicheng Pharmaceutical Technology Development Co., Ltd., batch number: 1311379, traits and physical and chemical properties: white crystal or crystalline powder.

[0149] 2. Monoammonium glycyrrhi...

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Abstract

The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition of acetaminophen and glycyrrhizic acid or medicinal salt thereof or medicinal derivative thereof. The weight ratio of acetaminophen to glycyrrhizic acid or medicinal salt thereof or medicinal derivative thereof is (40:1)-(1:1). Glycyrrhizic acid medicinal salt or glycyrrhizic acid medicinal derivative is selected from mono-ammonium glycyrrhizinate, diammonium glycyrrhizinate, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, disodium glycyrrhizate, trisodium glycyrrhetate, magnesium isoglycyrrhizinate, glycyrrhetinic acid or glycyrrhizin. The invention further relates to an oral drug prepared from the pharmaceutical composition, and the oral drug can be tablets, capsules or particles. By the adoption of the pharmaceutical composition, liver injury caused by acetaminophen can be reduced to a certain extent, using convenience is ensured, and therefore a solution is provided for safer and more efficient use of acetaminophen.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition composed of acetaminophen and glycyrrhizic acid or a pharmaceutically acceptable salt or a pharmaceutically acceptable derivative thereof. Background technique [0002] As we all know, the liver is the main organ for drug accumulation, transformation, and metabolism. Especially, oral drugs enter the liver after being absorbed by the gastrointestinal tract. Usually, the drug concentration in the liver is higher than that in the blood and other organs. Therefore, when the dosage of the drug is too large or the medication time is too long, it will cause damage to the liver, especially when two or more drugs are used inappropriately, the damage will be even worse, which will cause some liver cell necrosis, manifested as jaundice, Abnormal liver function indicators such as elevated serum alanine aminotransferase. Generally speaking, due to the toxic effects...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/56A61P29/00A61K31/167
Inventor 王锦刚赵勇刚张胜海
Owner COSCI MED TECH CO LTD
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