Nasal cavity spraying agent and preparation method thereof, and biological barrier film

A nasal spray and biological technology, applied in the medical field, can solve the problems of poor aesthetics and comfort, poor barrier effect, and difficulty in effectively blocking micron-level allergens when wearing a mask, and achieve good barrier effect, uniform distribution, and rapid The effect of film formation

Active Publication Date: 2017-06-13
成都博创必成生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the commonly used method to avoid exposure to allergens is to wear a mask, but its barrier effect is po

Method used

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  • Nasal cavity spraying agent and preparation method thereof, and biological barrier film
  • Nasal cavity spraying agent and preparation method thereof, and biological barrier film
  • Nasal cavity spraying agent and preparation method thereof, and biological barrier film

Examples

Experimental program
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Effect test

preparation example Construction

[0042] The present invention provides a kind of preparation method of nasal cavity spray described in above-mentioned technical scheme, comprises the following steps:

[0043] a), mixing cellulose, humectant and solvent to obtain nasal cavity spray.

[0044] In the preparation method provided by the invention, the nasal cavity spray can be obtained by directly mixing the cellulose, the moisturizing agent and the solvent uniformly in proportion. Specifically, the process includes:

[0045] a1), mixing the moisturizing agent with part of the solvent to obtain the first mixed liquid;

[0046] a2), mixing the first mixed solution with cellulose to obtain a second mixed solution;

[0047] a3), mixing the second mixed solution with the remaining amount of solvent to obtain a nasal cavity spray.

[0048] In the above preparation method provided by the present invention, firstly, the moisturizing agent is mixed with part of the solvent. Wherein, the part of the solvent accounts for ...

Embodiment 1

[0057] Preparing a Nasal Spray

[0058] Weigh 100.0g of glycerin and 2.5g of water-soluble mint essence, put them in a 2000ml beaker, add 700ml of purified water, stir evenly, then heat up the water bath to 60°C, continue stirring, and slowly add hydroxypropyl methylcellulose (model: E4M, manufacturer: Shanghai Colorcon Coating Technology Co., Ltd.) 12.5g, after being uniformly dispersed, keep stirring and cool down to room temperature, add a certain amount of HCl to adjust the pH value of the solution, then place the solution in a steam sterilizer, and Sterilize at 121°C for 35 minutes, add purified water to 1000ml on a clean bench, and stir for 30 minutes to obtain a nasal spray sample with a pH value of 6.5, and distribute the sample into nasal spray bottles on a clean bench.

Embodiment 2

[0060] Preparing a Nasal Spray

[0061] Weigh 100.0g of glycerin and 2.5g of water-soluble rose essence, put them in a 2000ml beaker, add 700ml of purified water, stir well, then heat up the water bath to 60°C, continue stirring, and slowly add hydroxypropyl methylcellulose (model: E4M, manufacturer: Shanghai Colorcon Coating Technology Co., Ltd.) 12.5g, after being uniformly dispersed, keep stirring and cool down to room temperature, add a certain amount of phosphate buffered saline to adjust the pH value of the solution, and then place the solution in a steam sterilizer , at 121°C, sterilize for 35 minutes, add purified water to 1000ml on a clean bench, and stir for 30 minutes to obtain a nasal spray sample with a pH value of 7.0, and distribute the sample into nasal spray bottles on a clean bench.

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Abstract

The invention belongs to the medical field, and in particular, relates to a nasal cavity spraying agent and a preparation method thereof, and a biological barrier film. The nasal spraying agent provided by the invention includes cellulose, a moisturizing agent and a solvent; the cellulose includes hydroxypropyl methyl cellulose with the type of E4M and/or hydroxyethyl methyl cellulose with the type of 20WR, and the content of the cellulose in the nasal cavity spraying agent is 9-13 g/L; the moisturizing agent includes one or more of glycerol, propylene glycol and sorbitol, and the content of the moisturizing agent in the nasal cavity spraying agent is 70-130 g/L. After the nasal cavity spraying agent is sprayed into a nasal cavity, the nasal cavity spraying agent can be evenly distributed in the nasal cavity and rapidly forms a film, and a formed film is uniform and has good barrier effect on most allergens. Experimental results show that the biological barrier film formed by the nasal cavity spraying agent provided by the invention can effectively block most allergens with the particle size of PM 2.5 or more.

Description

technical field [0001] The invention belongs to the medical field, and in particular relates to a nasal cavity spray, a preparation method thereof and a biological barrier film. Background technique [0002] Allergic rhinitis (allergic rhinitis, AR) refers to the oversensitivity of the nasal mucosa to certain stimuli and produces a strong reaction beyond the normal range. It is called nasal hyperresponsive rhinopathy in medicine. The incidence of allergic rhinitis is extremely high, and it is a common and frequently-occurring disease worldwide, with more than 500 million patients worldwide. The prevalence of allergic rhinitis in my country is 10% to 24%, that is to say, there are about 140 million allergic rhinitis patients in my country. The incidence of allergic rhinitis has been on the rise in most countries in recent years, and WHO has listed allergic rhinitis as a public health problem of global concern. [0003] April 11th is "National Nose Love Day", and April 13th ...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K9/70A61K31/717A61K31/047A61P11/02A61P37/08
CPCA61K9/0043A61K9/12A61K9/7015A61K31/047A61K31/717A61K2300/00
Inventor 万方杨华蓉江敏杨青张劲松
Owner 成都博创必成生物技术有限公司
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