Gold nanorod-lipid polymer vesicle with transdermal delivery function and preparation method and application of gold nanorod-lipid polymer vescle

A technology of gold nanorods and nanovesicles, which is applied in the field of medicine, can solve the problems of destroying the structure of the stratum corneum of the skin and skin irritation, and achieve the effects of enhancing transdermal efficiency, promoting release, and good biocompatibility
CN106821986AActive Publication Date: 2017-06-13ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2017-06-13

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Abstract

The invention discloses gold nanorod-lipid polymer vesicle with the transdermal delivery function and a preparation method and application of the gold nanorod-lipid polymer vescle. The nano vesica include the lipid polymer vesicle and a gold nanorod attached to the interior of the lipid polymer vesicle, the nano vesica good in stability have thermal responsiveness and good biocompatibility, the lipid structure on the uttermost side can be fused with skin keratinocytes to penetrate the skin to enter subcutaneous tumor site, good gene therapy and thermal therapy effect on melanoma on the surface of the skin is achieved, and the advantages of targeted controllable drug delivery is realized. Efficient gene therapeutic effect is achieved, and the gold nanorod-lipid polymer vesicle is quite possible to be good carrier for local delivery of gene drugs; the carrier system has wide application prospect in treating tumors of the melanoma of the skin through transdermal genes; new research thought and technical reference are provided for design of a further gene drug transdermal delivery system.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a gold nanorod-lipid polymer vesicle with the function of transdermal drug delivery and its preparation method and application. Background technique

[0002] Transdermal therapeutic system (TTS) refers to the drug delivery on the surface of the skin, and the drug penetrates the stratum corneum, epidermis, and dermis at a constant speed, and finally enters the systemic circulation to produce systemic or local therapeutic effects. Compared with oral and injection administration, it has the following three advantages: 1. The administration method is convenient, has less impact on the human body and the administration can be stopped in time when side effects occur; 2. It can avoid the first-pass effect produced by the liver and improve Drug bioavailability; 3. It is conducive to the controlled and slow release of drugs over a period of time. However, while the stratum corneum effec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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