Gold nanorod-lipopolymer vesicle with transdermal drug delivery function and its preparation method and application
A gold nanorod, polymer technology, applied in the field of medicine, can solve the problems of destroying the skin stratum corneum structure, skin irritation, etc., and achieve the effects of enhancing the transdermal efficiency, promoting release, and promoting drug release.
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Embodiment 1
[0038] Preparation of gold nanorod-lipopolymer vesicles
[0039] (1) Preparation of polymer PSAA
[0040]Using a high-pressure reactor as a reactor, add allyl alcohol (AA), dicumyl peroxide (DCP) and styrene (ST) into the reactor, use nitrogen as a protective agent, and allyl alcohol and styrene as The mass of the two reaction raw materials is 0.5g and 0.5g respectively, dicumyl peroxide is used as the initiator, the addition amount is 1mg, the reaction temperature is 50°C, and the reaction time is 1h, and the polymer PSAA is finally obtained.
[0041] (2) Preparation of lipopolymer vesicles
[0042] Under pulsed ultrasound, the polymer 5 gPSAA was mixed with 5 mL ultrapure water, and dioleoylphosphatidylethanolamine and (2,3-dioleoyl-propyl)-trimethylamine mixed in any ratio were added as surface active agent, the quality of the surfactant was 1 mg, and the lipopolymer vesicles were prepared.
[0043] (3) Preparation of gold nanorods
[0044] When light is incident on the...
Embodiment 2
[0051] Preparation of gold nanorod-lipopolymer vesicles
[0052] (1) Preparation of polymer PSAA
[0053] Using a high-pressure reactor as a reactor, add allyl alcohol (AA), dicumyl peroxide (DCP) and styrene (ST) into the reactor, use nitrogen as a protective agent, and allyl alcohol and styrene as The mass of the two reaction raw materials is 5g and 0.5g respectively, dicumyl peroxide is used as the initiator, the addition amount is 550mg, the reaction temperature is 150°C, and the reaction time is 10h, and the polymer PSAA is finally obtained.
[0054] (2) Preparation of lipopolymer vesicles
[0055] Under pulsed ultrasound, the polymer 5 gPSAA was mixed with 50 mL ultrapure water, and dioleoylphosphatidylethanolamine and (2,3-dioleoyl-propyl)-trimethylamine mixed in any ratio were added as surfactants , the quality of the surfactant is 550 mg, and the lipopolymer vesicles are prepared.
[0056] (3) Preparation of gold nanorods
[0057] When light is incident on the gol...
Embodiment 3
[0064] Validation of gold nanorod-lipopolymer vesicles
[0065] (1) Particle size measurement of gold nanorod-lipopolymer vesicles
[0066] First use ultrapure water to adjust the gold nanorods synthesized in Example 1 to 100 μg / mL, and measure the size of the gold nanorods under the Malvern laser particle size analyzer, the results are as follows figure 1 shown.
[0067] Use ultrapure water to adjust the lipopolymer vesicles synthesized in Example 1 to 100 μg / mL, measure the size of the lipopolymer vesicles under the Malvern laser particle size analyzer, the results are as follows figure 2 shown.
[0068] Use ultrapure water to adjust the gold nanorod-lipopolymer vesicles synthesized in Example 1 to 100 μg / mL, and measure the size of the gold nanorod-lipopolymer vesicles under a Malvern laser particle sizer, The result is as image 3 shown.
[0069] (2) Morphological observation of gold nanorods
[0070] Get the gold nanorod solution of Example 1, drop it on a dedicate...
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