Fructus chebulae immaturus extract and preparation method and application thereof

A technology of extract and green fruit, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of nutritional imbalance, easy recurrence, water and electrolyte disorder, etc., achieve the effect of reducing expression, increasing SOD activity, and improving abdominal pain

Active Publication Date: 2017-06-13
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the characteristics of high morbidity, slow recovery after treatment and easy recurrence. If the treatment is not timely, it can cause diarrhea, water and electrolyte disorders, nutritional disorders, etc., and make the disease worse.
At present, there is no effective treatment drug or method. Generally, symptomatic treatment is selected, mainly Western medicine, such as anti-inflammatory and pain relief, rehydration and antidiarrheal, etc., but the effect is often poor, which brings great inconvenience and pain to the work and life of the patient.

Method used

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  • Fructus chebulae immaturus extract and preparation method and application thereof
  • Fructus chebulae immaturus extract and preparation method and application thereof
  • Fructus chebulae immaturus extract and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Preparation of Xiqingguo Extract

[0025] (1) Pulverize 500g of Xiqingguo and pass through a 40-mesh sieve, take the material under the sieve, use supercritical fluid extraction method, and use supercritical CO 2 As a supercritical extractant, extract the cypress fruit with a particle size of -40 mesh at a speed of 0.62g / min for 6h at 40°C and 300bar, and collect the extract every 20min;

[0026] (2) using a supercritical fluid extraction device, using acetone as the extractant, extracting the cypress fruit after the treatment in step (1) again to obtain an extract A, the extraction is at 40 ° C, 300 bar under conditions of 5.6 Extraction at the speed of g / min for 6h, and collect the extract every 20min;

[0027] (3) using a supercritical fluid extraction device, using water as the extractant, extracting the cypress fruit after the step (2) treatment again to obtain an extract B, the extraction is at 40 ° C, 300 bar under conditions of 7.1 Extraction at the speed of g...

Embodiment 2

[0030] Preparation of Xiqingguo Extract

[0031] (1) Pulverize 400 g of xiqingguo and pass through a 40-mesh sieve, take out the under-sieve, use supercritical fluid extraction method, and use supercritical CO2 2 As a supercritical extractant, extract the cypress fruit with a particle size of -40 mesh at a speed of 0.58g / min for 6h at 45°C and 350bar, and collect the extract every 20min;

[0032] (2) using a supercritical fluid extraction device, using acetone as the extractant, extracting the cypress fruit after the step (1) treatment again, to obtain the extract A, the extraction is at 45 ° C, 350 bar under the condition of 6.4 Extraction at the speed of g / min for 6h, and collect the extract every 20min;

[0033] (3) using a supercritical fluid extraction device, using water as the extractant, extracting the cypress fruit after the treatment in step (2) again to obtain extract B, the extraction is at 45 ° C, under 350bar conditions with 8.1 Extraction at the speed of g / min...

Embodiment 3

[0036] Preparation of Xiqingguo Extract

[0037] (1) Pulverize 500g of Xiqingguo and pass through a 40-mesh sieve, take the material under the sieve, use supercritical fluid extraction method, and use supercritical CO 2 As a supercritical extractant, extract the cypress fruit with a particle size of -40 mesh at a speed of 1.0g / min for 6h at 35°C and 450bar, and collect the extract every 20min;

[0038] (2) using a supercritical fluid extraction device, using acetone as the extractant, extracting the cypress fruit after the treatment in step (1) again to obtain an extract A, the extraction is at 35 ° C, 450 bar under conditions of 7.8 Extraction at the speed of g / min for 6h, and collect the extract every 20min;

[0039] (3) using a supercritical fluid extraction device, using water as the extractant, extracting the cypress fruit after the treatment in step (2) again to obtain extract B, the extraction is at 35 ° C, under 450 bar conditions with 5.0 Extraction at the speed of ...

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Abstract

The invention relates to a fructus chebulae immaturus extract and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparation. The fructus chebulae immaturus extract has the effects of clearing away heat and toxic materials, astringing to arrest diarrhea, resisting inflammation and oxidization and the like, and can be used for repairing radioactive injuries, treating intestinal mucosal hyperemia, edema and cell injuries caused by radiographic exposure, and improving the symptoms of stomachache, diarrhea, bloody purulent stool and the like. As proved by experiments, the fructus chebulae immaturus extract can be used for resisting inflammatory injury caused by radiation at a certain degree, lowering the expression of an inflammatory factor TNF-alpha, and increasing the SOD (Superoxide Dismutase) activity of an oxidation-resistant active enzyme (p is less than 0.05). The fructus chebulae immaturus extract can be used for preparing radioactive enteritis medicine, and a novel method is provided for clinical treatment of radioactive enteritis.

Description

technical field [0001] The invention belongs to the technical field of preparation of Chinese herbal medicines, and in particular relates to an extract of Xiqingguo and a preparation method and application thereof. Background technique [0002] With the deterioration of environmental pollution, food insecurity and social pressure, the incidence of malignant tumors is getting higher and higher. In clinical treatment of abdominal or pelvic malignant tumors, in addition to surgery, chemotherapy and other methods, it is often used in combination or alone. Radiation Therapy. Among them, radiation enteritis (Radiation proctitis) is a common intestinal complication caused by radiation therapy for malignant tumors such as the pelvis. It has the characteristics of high incidence, slow recovery from treatment and easy recurrence. If the treatment is not timely, it can cause diarrhea, water and electrolyte disorders, nutritional disorders, etc., and make the disease worse. At present...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/00
CPCA61K36/185A61K2236/33A61K2236/331A61K2236/37A61K2236/39A61K2236/51
Inventor 刘松青刘芳赵鸿燕谢永红戴青
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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