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Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating diseases of digestive system department

A technology of gastroenterology and composition, applied in the directions of drug combination, drug delivery, digestive system, etc., can solve the problems of many adverse reactions and side effects, difficult for patients to accept, and expensive treatment costs.

Inactive Publication Date: 2021-07-16
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the treatment of pancreatitis mostly adopts surgery or chemical medicine treatment, wherein the surgical treatment is likely to cause secondary damage to the patient, and the treatment cost is relatively expensive, so it is not easy to be accepted by the patient; chemical medicine treatment is generally based on the application of antibiotics and hormones, but It can only relieve symptoms in the short term, treat the symptoms but not the root cause, the cure rate is low, and there are many adverse reactions and side effects, which seriously affect the quality of life of patients

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating diseases of digestive system department
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating diseases of digestive system department
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating diseases of digestive system department

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The preparation of embodiment 1 Jingfang granules

[0068]

[0069] A. Nepeta, Fangfeng, Notopterygium, Duhuo, Peucedanum, Chuanxiong and Citrus aurantium were extracted to obtain volatile oils of 7 kinds of medicinal materials, and the distilled medicinal residues, Chuanxiong and Citrus aurantium distilled aqueous solution were used for later use;

[0070] B. Get the volatile oil gained in step A, add β-cyclodextrin respectively to make clathrate;

[0071] C. the distilled aqueous solution of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A is made into 25% ethanol solution as solvent, and the medicinal residues of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A are percolated with Poria cocos to obtain percolation liquid for subsequent use;

[0072] D. Decoct the medicinal residues of Schizonepeta, Fangfeng, Notopterygium, Duhuo and Peucedanum obtained in step A with the rest of Bupleurum, Platycodon grandiflora, and licorice, and...

Embodiment 2

[0075] The preparation of embodiment 2 Jingfang tablet

[0076]

[0077] A. Nepeta, Fangfeng, Notopterygium, Duhuo, Peucedanum, Chuanxiong and Citrus aurantium were extracted to obtain volatile oils of 7 kinds of medicinal materials, and the distilled medicinal residues, Chuanxiong and Citrus aurantium distilled aqueous solution were used for later use;

[0078] B. Get the volatile oil gained in step A, add β-cyclodextrin respectively to make clathrate;

[0079] C. the distilled aqueous solution of Rhizoma Chuanxiong and Fructus Aurantii obtained in step A is made into 20% ethanol solution as a solvent, and the medicinal residues of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A are percolated with Poria cocos to obtain percolation liquid for subsequent use;

[0080] D. Decoct the medicinal residues of Schizonepeta, Fangfeng, Notopterygium, Duhuo and Peucedanum obtained in step A with the rest of Bupleurum, Platycodon grandiflora, and licorice for 3 hours...

Embodiment 3

[0083] The preparation of embodiment 3 Jingfang capsules

[0084]

[0085] A. Nepeta, Fangfeng, Notopterygium, Duhuo, Peucedanum, Chuanxiong and Citrus aurantium were extracted to obtain volatile oils of 7 kinds of medicinal materials, and the distilled medicinal residues, Chuanxiong and Citrus aurantium distilled aqueous solution were used for later use;

[0086] B. Get the volatile oil gained in step A, add β-cyclodextrin respectively to make clathrate;

[0087] C. the distilled aqueous solution of Rhizoma Chuanxiong and Fructus Aurantii obtained in step A is made into 30% ethanol solution as a solvent, and the medicinal residues of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A are percolated with Poria cocos to obtain percolation liquid for subsequent use;

[0088]D. Add the dregs of Schizonepeta, Fangfeng, Notopterygium, Duhuo and Peucedanum obtained in step A with the rest of Bupleurum, Campanulaceae, Licorice and other three flavors, add water and ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses application of a traditional Chinese medicine composition in preparation of medicines for preventing or treating diseases of the digestive system department. The traditional Chinese medicine composition is prepared from 11 raw medicinal materials including herba schizonepetae, radix saposhnikoviae, notopterygium root, radix angelicae pubescentis, radix bupleuri, radix peucedani, ligusticum wallichii, fructus aurantii, poria cocos, platycodon grandiflorum and liquorice. The application of the traditional Chinese medicine composition is a new application of development of a listed product, specifically, a Jingfang preparation. Pharmacological experiments show that the traditional Chinese medicine composition can effectively reduce the activity of serum amylase and serum lipase, relieve inflammatory response, reduce the release level of inflammatory cytokines TNF-alpha and IL-6 in serum, enhance the activity of SOD in pancreatic tissue and reduce the content of MDA in tissue, treats both symptoms and root causes, and has an exact treatment effect on pancreatitis.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of medicines for preventing or treating digestive diseases, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Gastroenterology is a medical discipline that studies diseases of the esophagus, stomach, small intestine, large intestine, liver, gallbladder, and pancreas. Gastroenterology diseases mainly include gastrointestinal diseases, liver diseases, biliary system diseases, pancreas diseases, peritoneal and mesenteric diseases, etc. Pancreatic diseases include pancreatic congenital diseases, pancreatic injury diseases, pancreatic inflammatory diseases, pancreatic cystic lesions and pancreatic secretory tumors. [0003] Pancreatitis (pancreatitis) is a disease caused by the self-digestion of trypsin in the pancreas. Th...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/00A61K47/69A61P1/18
CPCA61K36/538A61K36/238A61K36/237A61K36/232A61K36/233A61K36/23A61K36/236A61K36/752A61K36/076A61K36/346A61K36/484A61K9/0053A61P1/18A61K47/6951A61K2236/333A61K2236/37
Inventor 张贵民李蔚群郝大伟
Owner LUNAN PHARMA GROUP CORPORATION
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