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A kind of Duhuo granule and its preparation method and quality control method

A unique and granular technology, used in measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of losing the shape characteristics of medicinal materials, small dosage, etc., to achieve easy quality control, strong specificity, and effective qualitative. Effect

Active Publication Date: 2020-08-21
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Compared with the traditional Chinese medicine decoction, it is convenient to take, the dosage is small, the quality is controllable, it is easy to store, and it is easy to carry. The medicinal materials are identified and differ in their quality control from the original medicinal materials

Method used

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  • A kind of Duhuo granule and its preparation method and quality control method
  • A kind of Duhuo granule and its preparation method and quality control method
  • A kind of Duhuo granule and its preparation method and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take 200kg of Duhuo decoction pieces, add water to decoct twice, decoct with 10 times the weight of Duhuo decoction pieces in water for 2 hours, add 8 times the weight of Duhuo decoction pieces in the second decoction and decoct for 2 hours, combine the two decoctions, and concentrate in vacuum to Extraction with a relative density of 1.0-1.1 (80°C), spray drying (inlet air temperature 185°C-200°C, outlet air temperature 90°C-110°C; extract preheating temperature 50°C-60°C; material pump speed 450 -700 rev / min), to get lovage spray-dried powder, add 0-5% dextrin (calculated based on the weight of lovage spray-dried powder), dry granulate, get lovage granules with a particle size of 18-40 mesh. Each gram of lovuo granules contains 5g of crude drug equivalent to lovuo decoction pieces.

[0042] After preparation, the Duhuo granules were qualitatively identified by thin-layer chromatography, and the specific methods were as follows:

[0043] Take 1g of this product, grind...

Embodiment 2

[0047] Embodiment 2: the preparation method of lovage granules:

[0048] Take 200kg of Duhuo decoction pieces, add water to decoct twice, decoct with 8 times the weight of Duhuo decoction pieces in water for 1 hour, add 6 times the weight of Duhuo decoction pieces in the second decoction and decoct for 1 hour, combine the two decoctions, and concentrate in vacuum to Extraction with a relative density of 1.0-1.1 (80°C), spray drying (inlet air temperature 185°C-200°C, outlet air temperature 90°C-110°C; extract preheating temperature 50°C-60°C; material pump speed 450 -700 rev / min), to obtain lovage spray-dried powder, add 5-15% dextrin (calculated by the weight of lovage spray-dried powder), and dry granulate to obtain lovage granules with a particle size of 18-40 mesh. Each gram of lovuo granules contains 4g of crude drug equivalent to lovuo decoction pieces.

[0049] After preparation, the Duhuo granules were qualitatively identified by thin-layer chromatography, and the spe...

Embodiment 3

[0054] Embodiment 3: the preparation method of lovage granules:

[0055] Take 200kg of Duhuo decoction pieces, add water to decoct twice, decoct with 8 times the weight of Duhuo decoction pieces in water for 1 hour, add 6 times the weight of Duhuo decoction pieces in the second decoction and decoct for 1 hour, combine the two decoctions, and concentrate in vacuum to Extraction with a relative density of 1.0-1.1 (80°C), spray drying (inlet air temperature 185°C-200°C, outlet air temperature 90°C-110°C; extract preheating temperature 50°C-60°C; material pump speed 450 -700 rev / min), to obtain lovage spray-dried powder, add 15-25% dextrin (calculated based on the weight of lovage spray-dried powder), and dry granulate to obtain lovage granules with a particle size of 18-40 mesh. Each gram of Duhuo granules contains 3.3g of crude drug equivalent to Duhuo decoction pieces.

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Abstract

The invention discloses heracleum hemsleyanum michaux granules, and a preparation method and a quality control method thereof, relating to the technical field of preparation and quality control methods of traditional Chinese medicine granules. Every gram of heracleum hemsleyanum michaux granules is equivalent to 3-5 grams of the crude drug of the heracleum hemsleyanum michaux decoction pieces. The preparation method of the heracleum hemsleyanum michaux granules comprises the following steps: taking the heracleum hemsleyanum michaux decoction pieces, adding water, decocting, concentrating the liquor to obtain an extract with the relative density of 1.0-1.1 (80 DEG C), and drying to obtain the heracleum hemsleyanum michaux spray-dried powder; adding dextrin, which accounts for 0-25 wt% of the heracleum hemsleyanum michaux spray-dried powder, into the heracleum hemsleyanum michaux spray-dried powder; and granulating to obtain the heracleum hemsleyanum michaux granules. The quality control method of the heracleum hemsleyanum michaux granules comprises a high-efficiency liquid-phase fingerprint detection process of heracleum hemsleyanum michaux granules and a thin-layer indentification process of the heracleum hemsleyanum michaux granules. The heracleum hemsleyanum michaux granules are subjected to high-efficiency liquid-phase fingerprint detection to determine the osthole content. The heracleum hemsleyanum michaux granules have the advantages of advanced and stable production technique and controllable quality control standard; and fingerprint and content determination detection processes are used for controlling the quality of the traditional Chinese medicine granules, so that the product quality is ensured more effectively.

Description

technical field [0001] The invention relates to the technical field of preparation and quality control methods of traditional Chinese medicine granules. Background technique [0002] Duhuo Formula Granules are Angelica Placiformis, an umbrella plant Angelica pubescens Maxim. f. biserrata The dried root of Shan et Yuan is processed into formula granules. It has aroma, slightly pungent taste, and slightly numb tongue. It has the functions of expelling wind and dampness, clearing numbness and relieving pain. Fufeng headache, wind-cold dampness headache. [0003] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, use single Chinese herbal decoction pieces that meet the processing specifications as raw materials, and adopt the advanced technology and methods of the modern pharmaceutical industry. After extraction, concentration, drying, and granulation, they are made into certain specifications for medical institut...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02A61K36/232A61K9/16A61P29/00A61P25/00G01N30/90G01N30/34A61K125/00
CPCA61K9/1652A61K36/232A61K2236/331A61K2236/39A61K2236/51G01N30/02G01N30/34G01N30/90
Inventor 张肖建高晗魏彩彩李军山裴利利郝磊李振江
Owner SHINEWAY PHARMA GRP LTD