Amphiphilic medicine-medicine nanoparticle medicine for reversing multidrug resistance of tumor on platinum type anti-cancer medicine, and preparation method and application thereof
A multi-drug resistance and nanoparticle technology, which is applied in the field of anti-tumor drugs, can solve the problems of inflammation in kidneys and other organs and other diseases, and achieve high yield, reduce blockage, and reduce toxic and side effects
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Embodiment 1
[0033] Embodiment 1: The preparation of an amphiphilic drug-drug nanoparticle drug for reversing the multidrug resistance of tumors to platinum anticancer drugs in this embodiment 1 specifically includes the following steps:
[0034] (1) Dissolve 300 mg of cisplatin and 169.87 mg of silver nitrate in 10 mL of DMF, react for 24 hours and remove the precipitated silver chloride to obtain the supernatant as solution 1; mix and disperse 88.1 mg of vorinostat and 13.3 mg of sodium hydroxide In 5 mL of methanol, the insoluble matter was removed after the reaction, and the supernatant was obtained as solution 2; after the solution 1 and solution 2 were mixed and reacted for 48 hours, the organic solvent was removed, the excess cisplatin was dissolved in methanol, and the amphiphilic drug was obtained by recrystallization. - drug complex, its structural formula (1) is as follows;
[0035]
[0036] Structural formula (a) 1H-NMR nuclear magnetic spectrum, mass spectrogram and infrar...
Embodiment 2
[0038] Embodiment 2: The preparation of an amphiphilic drug-drug nanoparticle drug for reversing the multidrug resistance of tumors to platinum anticancer drugs in this embodiment 2 specifically includes the following steps:
[0039] (1) Dissolve 391mg of picoplatin and 169.87mg of silver nitrate in 10mL of DMF, react for 24h to remove the silver chloride precipitate, and obtain the supernatant as solution 1; mix 100.7mg of trichostatin A with 35.3mg of sodium carbonate Disperse in 5mL of methanol, remove the insoluble matter after the reaction, and obtain the supernatant solution 2; after mixing the solution 1 and the solution 2 for 48 hours, remove the organic solvent, dissolve and remove the excess picoplatin with methanol, and recrystallize to obtain amphiphilic Drug-drug complex, its structural formula (2) is as follows;
[0040]
[0041] (2) Dissolve the amphiphilic drug-drug complex prepared above in methanol, drop it into water at room temperature, remove methanol, ...
Embodiment 3
[0042] Embodiment 3: The preparation of an amphiphilic drug-drug nanoparticle drug for reversing the multidrug resistance of tumors to platinum anticancer drugs in this embodiment 3 specifically includes the following steps:
[0043] (1) Dissolve 300mg cisplatin and 169.87mg silver nitrate in 10mL DMF, remove the silver chloride precipitate after reacting for 24h, and obtain the supernatant as solution one; mix 42.3mg 3,4-dihydroxybenzohydroxamic acid with Mix and disperse 35.3 mg of sodium carbonate in 5 mL of DMF, remove the insoluble matter after the reaction, and obtain the supernatant as solution 2; after mixing and reacting solution 1 and solution 2 for 48 hours, remove the organic solvent, dissolve and remove excess cisplatin with methanol, and recrystallize Obtain the amphiphilic drug-drug complex, and its structural formula (3) is as follows;
[0044]
[0045] (2) dissolving the amphiphilic drug-drug complex prepared above in dimethyl sulfoxide, dripping it into wa...
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Abstract
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