Hydrogel based on single-stranded ultra-internal cyclopolymer and application of hydrogel

Abstract

The invention discloses hydrogel based on a single-stranded ultra-internal cyclopolymer and application thereof. The single-stranded ultra-internal cyclopolymer obtained by homopolymerizing monomer polyethylene glycol diacrylate by adopting a controllable reactive radical polymerization method for zero-valent copper regulation and control is taken as a precursor, 2,2-dimethoxy-phenylacetophenone is taken as an ultraviolet light initiator, water is taken as a solvent, and carbon-carbon double bonds in the precursor are initiated under the irradiation of ultraviolet light for cross-linking to form a hydrogel material. The characterization of the polymer proves that a constant of a Mark-Hovink formula of the single-stranded ultra-internal cyclopolymer is 0.5, and the structure of the single-stranded ultra-internal cyclopolymer is similar to a spherical shape. Known from an ultraviolet light-rheology joint test, the single-stranded ultra-internal cyclopolymer can be quickly formed, is of a highly-cyclized structure and has higher storage modulus through a large amount of vinyl; the hydrogel has higher adhesion strength, lower swelling property, slower degradation property and better cell compatibility, and can be used as a wound dressing or a tissue adhesive.

Description

technical field [0001] The invention belongs to the field of novel biomedical materials, and mainly relates to a hydrogel based on a single-chain ultra-internal cyclic polymer and its application. Background technique [0002] Wound dressings are the primary modality in the treatment of acute and chronic wounds. In recent decades, various special wound dressings have been researched and invented according to different wound situations. Among them, as one of the new wound dressings, hydrogel wound dressings have been widely used due to their smooth surface, good biocompatibility, tight integration with uneven wounds, and promotion of epithelial cell growth. However, the currently widely used synthetic hydrogel dressings generally have problems such as poor wound tissue adhesion, mismatch between mechanical properties and wound tissue, and high biological toxicity. Studies have found that the performance of synthetic hydrogel wound dressings can be improved by controlling th...

AI Technical Summary

Problems solved by technology

However, the report on the preparation of hydrogel materials by single-chain ultra-internal cyclic polymers has not yet been proposed.

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