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Aspirin recovery product treatment method

A technology of aspirin and a treatment method, which is applied in the separation/purification of carboxylic acid compounds, organic chemistry and other directions to achieve the effect of saving raw materials and reducing costs

Inactive Publication Date: 2017-06-30
SHANDONG XINHUA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acylation mother liquor is concentrated under reduced pressure to recover acetic acid, and the raffinate is cooled and centrifuged to obtain the aspirin recovery product; the recovery product can be directly used as salicylic acid to prepare aspirin, but after several times of application, the impurity level is getting higher and higher, so it can no longer be used mechanically

Method used

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  • Aspirin recovery product treatment method
  • Aspirin recovery product treatment method
  • Aspirin recovery product treatment method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take 5 g of recovered aspirin, add 200 ml of dichloromethane, stir and heat up to 40°C and reflux for 1 hour, filter while hot, wash the filter cake with 20 ml of dichloromethane, and dry to obtain 1.66 g of 4-hydroxyisophthalic acid with a purity of 97.07% The filtrate was concentrated under reduced pressure, a large number of crystals were precipitated during the concentration process, 2 / 3 of the dichloromethane was evaporated, the temperature was cooled to 5° C., centrifuged, and vacuum-dried to obtain 3.03 g of salicylic acid with a purity of 95.05%.

Embodiment 2

[0038] Take 5g of recovered aspirin, add 200ml of chloroform, stir and heat up to 60°C for reflux for 1 hour, filter while hot, wash the filter cake with 20ml of chloroform, and dry to obtain 1.61g of 4-hydroxyisophthalic acid with a purity of 97.51%; the filtrate is decompressed Concentrate, a large number of crystals are precipitated during the concentration process, 2 / 3 of the chloroform is distilled off, the temperature is lowered to 5° C., centrifuged, and vacuum-dried to obtain 3.01 g of salicylic acid with a purity of 95.69%.

Embodiment 3

[0040] Take 5 g of recovered aspirin, add 200 ml of dichloromethane, stir and heat up to 45°C and reflux for 1 hour, filter while hot, wash the filter cake with 20 ml of dichloromethane, and dry to obtain 1.502 g of 4-hydroxyisophthalic acid with a purity of 97.5% The filtrate was concentrated under reduced pressure, a large number of crystals were separated out during the concentration process, 2 / 3 of the dichloromethane was steamed, cooled to 5° C. for centrifugation, washed with 10 ml of dichloromethane, and dried in vacuo to obtain 3.4 g of salicylic acid with a purity of 95.51%.

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Abstract

The invention belongs to the technical field of medicine and chemical industry, and particularly relates to an aspirin recovery product treatment method, which comprises: taking an aspirin recovery product, adding an organic solvent, carrying out stirring heating reflux, and filtering while hot to obtain a filter cake and a filtrate; washing the filter cake by using an organic solvent, and dried to obtain 4-hydroxyisophthalic acid; and carrying out pressure reducing concentration on the filtrate, evaporating out 2 / 3 of the organic solvent, cooling to a temperature of 5 DEG C, carrying out centrifugation, washing with an organic solvent, and carrying out vacuum drying to obtain salicylic acid. According to the present invention, the treatment method is scientific, reasonable and simple, is easy to perform, and has characteristics of raw material saving and cost reducing.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a method for processing recycled aspirin. Background technique [0002] Aspirin is an antipyretic and analgesic with a long history, which was born on March 6, 1899. It is used to treat colds, fever, headache, toothache, arthralgia, rheumatism, and can also inhibit platelet aggregation. It is used to prevent and treat ischemic heart disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis. It is used in angioplasty and side effects Road grafts are also effective. Aspirin came into the market in 1898. In recent years, it has been found that it also has the effect of anti-platelet aggregation, so it has aroused great interest again. Aspirin and other salicylic acid derivatives are melt-esterified with polyvinyl alcohol, cellulose acetate and other hydroxyl-containing polymers to make them polymerized, and the anti-inflammato...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C51/47C07C65/03C07C51/43C07C65/10
CPCC07C51/42C07C51/43C07C51/47C07C65/03C07C65/10
Inventor 李兴泰黄爱军李敏之宋丽华
Owner SHANDONG XINHUA PHARMA CO LTD
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