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Composition capable of adjusting structure of intestinal floras and preparation method and applications thereof

A technology for regulating intestinal flora and composition, applied to medical preparations containing active ingredients, applications, drug combinations, etc., to achieve the effect of improving intestinal bacterial structure, saving time and cost, and safe and effective intestinal bacterial structure

Active Publication Date: 2017-07-14
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the combination of rehmannia glutinosa, poria cocos and ginseng to improve the structure of intestinal flora

Method used

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  • Composition capable of adjusting structure of intestinal floras and preparation method and applications thereof
  • Composition capable of adjusting structure of intestinal floras and preparation method and applications thereof
  • Composition capable of adjusting structure of intestinal floras and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Accurately weigh 465g of Rehmannia glutinosa, 132g of Poria cocos and 65g of ginseng, add 10 times the amount of water, soak for 30min, heat under reflux for 1h, filter, reflux 3 times, combine the filtrates, and concentrate under reduced pressure at 80°C until the relative density measured by heat is 1.25kg / L. Among them, about 0.472% of iridoid glycoside composition, about 0.143% of phenylethanoid glycoside composition, about 0.017% of furfural derivative composition, about 0.59% of ginsenoside composition, about 42% of oligosaccharide, The polysaccharide is about 19.21%, and the total paste yield is about 64%. The weight ratio of iridoid glycoside composition, phenethyl alcohol glycoside composition, furfural derivative composition, ginsenoside composition, oligosaccharide, polysaccharide, and total paste yield is about: 47.2:14.3:1.7:59:4200:1921 : 6400.

Embodiment 2

[0065] Accurately weigh 350g of Rehmannia glutinosa, 100g of Poria cocos and 50g of ginseng, add 10 times the amount of water, soak for 30min, heat under reflux for 1h, filter, reflux 3 times, combine the filtrates, and concentrate under reduced pressure at 80°C until the relative density measured by heat is 1.25kg / L. Among them, about 0.443% of iridoid glycoside composition, about 0.135% of phenylethanoid glycoside composition, about 0.015% of furfural derivative composition, about 0.59% of ginsenoside composition, about 40% of oligosaccharide, The polysaccharide is about 18.05%, and the total paste yield is about 63%. The weight ratio of iridoid glycoside composition, phenethyl alcohol glycoside composition, furfural derivative composition, ginsenoside composition, oligosaccharide, polysaccharide, and total paste yield is about: 44.3:13.5:1.5:59:4000:1805 : 6300.

Embodiment 3

[0067] Accurately weigh 285 g of Rehmannia glutinosa, 90 g of Poria cocos and 42 g of ginseng, add 10 times the amount of water, heat to reflux for 1 h, filter, and reflux for 3 times, combine the filtrates, and concentrate under reduced pressure at 80 °C to a relative density of 1.25 kg / L. Among them, about 0.430% of iridoid glycoside composition, about 0.129% of phenylethanoid glycoside composition, about 0.014% of furfural derivative composition, about 0.58% of ginsenoside composition, about 39% of oligosaccharide, The polysaccharide is about 18%, and the total paste yield is about 63%. The weight ratio of iridoid glycoside composition, phenethyl alcohol glycoside composition, furfural derivative composition, ginsenoside composition, oligosaccharide, polysaccharide, and total paste yield is about: 43.0:12.9:1.4:60:3900:1800 : 6300.

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Abstract

The invention discloses a composition capable of adjusting the structure of intestinal floras and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 4 to 20 parts of radix rehmanniae, 1 to 5 parts of poria cocos, and 0.1 to 3 parts of ginseng. The provided composition is made of pure natural plants. The optimal formula is obtained through a large amount of tests and a selected modern preparation technology. The test results show that the provided composition can obviously increase the number of beneficial bacteria such as lactobacillus, bifidobacteria, and the like, at the same time, can inhibit the growth of escherichia coli, enterococcus, and clostridium perfringens in the intestinal tracts, is capable of well regulating the intestinal tracts and treating intestinal diseases (constipation, abdominal distension, diarrhea, etc.), has a health care function, is very safe, and does not have any side or toxic effect.

Description

technical field [0001] The invention relates to a natural composition, in particular to a natural composition capable of regulating the structure of intestinal flora and improving intestinal health, and a preparation method and application thereof. Background technique [0002] A large number of microorganisms coexist in the human body, especially the intestinal microorganisms are the most important "endogenous environmental factors" of the human body. There are more than 100 genera and more than 400 species of bacteria, and the number is about 10 times that of the human body's own cells. The sum of the genomes of these microorganisms is called the "microbiome" or "human metagenome", also known as the second genome of the human body. The latest research believes that the human body is a "super organism" composed of host cells and symbiotic microbial cells, especially symbiotic intestinal flora. Changes in the composition of symbiotic microorganisms can also lead to changes ...

Claims

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Application Information

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IPC IPC(8): A23L33/00A61K36/804A61P1/00
CPCA23V2002/00A61K36/076A61K36/258A61K36/804A61K2236/331A61K2236/39A61K2236/51A61K2236/53A23V2200/30A23V2200/3204A23V2250/21A61K2300/00Y02A50/30
Inventor 李松林汤亚沈红徐金娣
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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