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Preparation method of ceramic toughened polymer HA-PDLLA-PUU and product thereof

A technology of HA-PDLLA-PUU and polymer is applied in the preparation of ceramic toughening polymer HA-PDLLA-PUU, and the ceramic field containing ceramic toughening polymer HA-PDLLA-PUU can solve the problem of improving the mechanical properties of composite stents limited, lack of non-covalent interactions, etc., to achieve the effect of improving interfacial compatibility and improving mechanical properties

Active Publication Date: 2017-07-18
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a lack of strong non-covalent interactions between PLA segments and HA ceramics in HA-PLA, such as hydrogen bonding, so that the interfacial compatibility between HA-PLA and HA ceramics is limited to the bridging effect of HA in HA-PLA. , leading to a limited improvement in the mechanical properties of the composite scaffold

Method used

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  • Preparation method of ceramic toughened polymer HA-PDLLA-PUU and product thereof
  • Preparation method of ceramic toughened polymer HA-PDLLA-PUU and product thereof
  • Preparation method of ceramic toughened polymer HA-PDLLA-PUU and product thereof

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Experimental program
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Embodiment 1

[0028] Option One

[0029] A preparation method of ceramic toughening polymer HA-PDLLA-PUU, comprising the steps of:

[0030] (1) Synthesis of HA-PDLLA: dry HA and lactide particles were mixed in a ratio of 1:150, and the Sn(Oct) 2 Catalyzed at 140°C and reacted under vacuum for 24 hours, then purified twice with dichloromethane and n-hexane co-precipitation system, and dried in vacuum to obtain HA-PDLLA, a material grafted with PDLLA on the surface of HA;

[0031] (2) Synthesis of HA-PDLLA-PUU: Fully dissolve the HA-PDLLA obtained in step (1) in anhydrous toluene. Add hexamethylene diisocyanate, react at 70°C for 5h, then add piperazine, react at 50°C for 10h, after the reaction is complete, add the solution dropwise to absolute ethanol, collect the product, and dichloromethane / anhydrous The product was purified twice in ethanol system to obtain HA-PDLLA-PUU after chain extension of HA-PDLLA.

[0032] Option II

[0033] A preparation method of ceramic toughening polymer H...

Embodiment 2

[0045] Utilize ceramic toughening polymer HA-PDLLA-PUU to strengthen the method for HA porous ceramics, comprise the steps:

[0046] HA-PDLLA-PUU was dissolved in dichloromethane to prepare a 1-10 wt.% solution, and placed on a magnetic stirrer to stir overnight to fully dissolve and disperse evenly. Then, the sintered HA porous ceramics were soaked in it, placed on a shaker, shaken and oscillated at room temperature for 24 hours, then taken out, and dried for 48 hours to obtain HA-PDLLA-PUU-reinforced HA porous ceramics.

[0047] image 3 It is the SEM picture of PDLLA, HA-PDLLA and HA-PDLLA-PUU combined with sintered HA ceramics. The results show that PDLLA forms a layer of porous film on the surface of the scaffold after PDLLA is combined with HA porous ceramics, and is combined with HA porous ceramics. There is a clear stratification phenomenon between them. When HA-PDLLA is combined with HA porous ceramics, HA-PDLLA does not form a continuous film on the ceramic surface...

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Abstract

The invention relates to a preparation method of a ceramic toughened polymer HA-PDLLA-PUU and a product thereof. The preparation method comprises the detailed steps of: firstly using hydroxyapatite (HA) to initiate ring opening and polymerization and form HA-polylactic-acid macromolecular alcohol (HA-PDLLA), then adding fatty diisocyanate and a chain expanding agent, and carrying out chain expanding by a two-step method to obtain the ceramic toughened polymer HA-PDLLA-PUU. The HA-PDLLA-PUU prepared by the invention is used as a bridge between a polymer and a HA porous ceramic to improve the interfacial compatibility between the polymer and the HA porous ceramic, so that the mechanical property of the composite ceramic is improved more effectively, the toughness and the fracture energy are better and the ceramic toughened polymer HA-PDLLA-PUU has important significance for effectively enhancing the mechanical property of the HA ceramic.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a preparation method of a ceramic toughening polymer HA-PDLLA-PUU, and also relates to ceramics containing the ceramic toughening polymer HA-PDLLA-PUU. Background technique [0002] Hydroxyapatite (HA) is a safe, non-toxic, good biocompatibility and osteoconductive bone repair material, but HA ceramics processed solely from HA have the disadvantages of high brittleness and low toughness, which lead to its use in Application in load-bearing bone repair is limited. Natural bone is a porous composite material composed of mineral phases, such as hydroxyapatite (HA), calcium phosphate, and organic phases, such as collagen. Bone provides both stiffness and strength, which together give natural bone its unique mechanical properties. Inspired by this, a large number of studies have attempted to combine HA with organic polymer materials to form inorganic-organic composites, in order to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/46C08G18/32C08G18/10C08G63/692C04B41/87C04B41/83
CPCC04B41/009C04B41/5048C04B41/83C04B41/87C08G18/10C08G18/4684C08G63/6922C04B35/447C04B38/00C04B41/4884C08G18/3206C08G18/3246
Inventor 罗彦凤吴进川王远亮
Owner CHONGQING UNIV