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Production technology of compound sodium gualenate gargle

A technology of sodium azulene sulfonate and production technology, applied in the field of production technology of compound sodium azulene sulfonate gargle, can solve problems such as taste influence, and achieve the effects of promoting release, good therapeutic effect and reducing the generation of dental plaque

Inactive Publication Date: 2017-07-25
江苏恩为众心生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorhexidine is used for coloring for a long time, which affects the sense of taste

Method used

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  • Production technology of compound sodium gualenate gargle

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Effect test

Embodiment 1

[0012] A kind of compound azulene sulfonate sodium gargle production process of the present invention comprises the following steps:

[0013] (a) Configuration solution I: Heat 84.978% by mass purified water to 34°C, add 12% by mass of amorphous sorbitol, 0.45% by mass of sodium benzoate, and 0.045% cetylpyridinium chloride was stirred for 20 minutes to obtain solution Ⅰ, non-crystalline sorbitol: it is both a humectant and a sweetener, the moisturizing effect is relatively mild, and the taste is also good. Sodium benzoate: It is a good food preservative; Cetylpyridinium chloride: It belongs to cationic surfactant, which increases the permeability of cell wall by reducing surface tension, thereby inhibiting and killing bacteria. It can be used in oral mucosa Adsorption, but no irritation to the oral mucosa, no coloring to the tooth surface, antibacterial effect on bacteria, and can reduce the formation of plaque;

[0014] (b) Prepare solution II: according to the formula rati...

Embodiment 2

[0018] A kind of compound azulene sulfonate sodium gargle production process of the present invention comprises the following steps:

[0019] (a) Configuration solution I: Heat 70.002% by mass purified water to 36°C, add 28% by mass of amorphous sorbitol, 0.55% by mass of sodium benzoate, and 0.055% cetylpyridinium chloride was stirred for 25 minutes to obtain solution Ⅰ, non-crystalline sorbitol: it is both a humectant and a sweetener, the moisturizing effect is relatively mild, and the taste is also good. Sodium benzoate: It is a good food preservative; Cetylpyridinium chloride: It belongs to cationic surfactant, which increases the permeability of cell wall by reducing surface tension, thereby inhibiting and killing bacteria. It can be used in oral mucosa Adsorption, but no irritation to the oral mucosa, no coloring to the tooth surface, antibacterial effect on bacteria, and can reduce the formation of plaque;

[0020] (b) Prepare solution II: Dissolve sodium azulene sulfo...

Embodiment 3

[0024] A kind of compound azulene sulfonate sodium gargle production process of the present invention comprises the following steps:

[0025] (a) Configuration solution I: Heat 76.77% by mass purified water to 35°C, add 20% by mass of amorphous sorbitol, 0.5% by mass of sodium benzoate, and 0.05% cetylpyridinium chloride was stirred for 23 minutes to obtain solution Ⅰ, non-crystalline sorbitol: it is both a humectant and a sweetener, the moisturizing effect is relatively mild, and the taste is also good. Sodium benzoate: It is a good food preservative; Cetylpyridinium chloride: It belongs to cationic surfactant, which increases the permeability of cell wall by reducing surface tension, thereby inhibiting and killing bacteria. It can be used in oral mucosa Adsorption, but no irritation to the oral mucosa, no coloring to the tooth surface, antibacterial effect on bacteria, and can reduce the formation of plaque;

[0026] (b) Prepare solution II: according to the formula ratio, ...

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PUM

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Abstract

The invention discloses a production technology of compound sodium gualenate gargle. The production technology comprises the steps of preparing a solution I: heating purified water, then adding non-crystalline sorbitol, sodium benzoate and cetylpyridinium chloride into the heated purified water, and stirring for 20min; preparing a solution II: dissolving sodium gualenate by using ethanol to obtain the solution II; preparing a solution III: heating RH40 hydrogenated castor oil and propylene glycol until being molten, adding spearmint essence, and evenly stirring to obtain the solution III; adding the solution II and the solution III into the solution I, stirring for 10min to obtain a semi-finished product, taking samples for laboratory test to obtain a cetylpyridinium chloride semi-finished product, and canning the semi-finished product when the semi-finished product is qualified; when the cetylpyridinium chloride is insufficient, adding the cetylpyridinium chloride, taking samples for detection until the semi-finished product is qualified, and starting to fill; after the finished product is tested to be qualified, enabling the finished product to be put in storage, and discarding the unqualified products.

Description

technical field [0001] The invention relates to a production process of compound sodium azulene sulfonate gargle. Background technique [0002] Common mouthwashes such as compound chlorhexidine gargle and concentrated tinidazole gargle contain antibiotics, resulting in imbalanced flora and poor taste. Chlorhexidine is used for coloring for a long time, which will affect the sense of taste. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a production process for compound sodium azulene sulfonate gargle. [0004] In order to solve the problems of the technologies described above, the invention provides a compound azulene sodium sulfonate gargle production process, comprising the following steps: [0005] (a) Preparation solution Ⅰ: heat purified water with a mass percentage of 70%-80% to 34-36°C, add 12%-28% by mass of non-crystalline sorbitol, and 0.45% by mass -0.55% sodium benzoate, cetylpyridinium chloride w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/49A61K8/46A61K8/368A61K8/34A61Q11/00A61K31/4425A61K9/08A61P1/02A61P31/04A61K31/185
CPCA61K8/345A61K8/368A61K8/466A61K8/4926A61K8/92A61K9/0056A61K9/08A61K31/185A61K31/4425A61K47/44A61Q11/00A61K2300/00
Inventor 江晶晶张振平周建兵
Owner 江苏恩为众心生物医药有限公司
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