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Acute bronchitis solution preparation for aerosol inhalation and preparation method of acute bronchitis solution preparation

A technology of nebulized inhalation and preparation, applied in the field of pharmacy, which can solve the problems of slow onset of action, large toxic and side effects, and large dosage, and achieve the effects of improving safety, reducing dosage, and changing the route of administration

Active Publication Date: 2017-07-25
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the onset of oral administration is slow, the dosage is large, and the side effects are relatively large. Therefore, it is urgent to develop a safer dosage form, so that the drug can directly enter the respiratory tract.

Method used

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  • Acute bronchitis solution preparation for aerosol inhalation and preparation method of acute bronchitis solution preparation
  • Acute bronchitis solution preparation for aerosol inhalation and preparation method of acute bronchitis solution preparation
  • Acute bronchitis solution preparation for aerosol inhalation and preparation method of acute bronchitis solution preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of active ingredients:

[0034] Houttuynia cordata 10-250 parts, Golden buckwheat 10-250 parts, Sijiqing 10-250 parts, Aster 5-150 parts, Peucedanum 5-100 parts, Citrus aurantium 5-100 parts, Ephedra 5-60 parts, Licorice 5 parts -60 copies

[0035] Houttuynia cordata and Citrus aurantii are distilled with water, and the distillate is collected; the dregs and other six flavors such as golden buckwheat are decocted twice, filtered, and the filtrate is combined, concentrated to an appropriate amount, and combined with the above distillate to obtain the active ingredient of the present invention.

[0036] (2) Preparation of solution for nebulized inhalation of acute branch:

[0037]

[0038] Weigh the active ingredient according to the prescription amount, add an appropriate amount of water for injection, and stir evenly to obtain solution 1; take sodium chloride and citric acid, add appropriate amount of water for injection, stir to dissolve, and obtain...

Embodiment 2

[0040] (1) Preparation of active ingredient: same as Example 1.

[0041] (2) Preparation of solution for nebulized inhalation of acute branch:

[0042]

[0043] Weigh the active ingredient according to the prescription amount, add an appropriate amount of water for injection, and stir evenly to obtain solution 1; take sodium chloride, add appropriate amount of water for injection, stir to dissolve, and obtain solution 2; combine solution 1 and solution 2, and stir evenly to obtain solution 2. Solution 3: Take another appropriate amount of disodium hydrogen phosphate, add appropriate amount of water for injection to prepare a 0.4mol / L solution, stir slowly and add it to solution 3, adjust the pH value to 4.0-7.0, add 1000ml of water for injection, fill and seal, Instantly.

Embodiment 3

[0045] (1) Preparation of active ingredient: same as Example 1.

[0046] (2) Preparation of solution for nebulized inhalation of acute branch:

[0047]

[0048] Weigh the active ingredient according to the prescription amount, add an appropriate amount of water for injection, and stir evenly to obtain solution 1; take magnesium chloride and citric acid, add appropriate amount of water for injection, stir to dissolve, and obtain solution 2; combine solution 1 and solution 2, stir evenly, Obtain solution 3; take another appropriate amount of disodium hydrogen phosphate, add appropriate amount of water for injection to prepare a 0.2mol / L solution, stir slowly and add it to solution 3, adjust the pH value to 5.0-6.0, add 1000ml of water for injection, fill and seal , that is.

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Abstract

The invention relates to an acute bronchitis solution preparation for aerosol inhalation, belonging to the field of pharmaceutics. The acute bronchitis solution preparation for aerosol inhalation comprises (1) acute bronchitis active ingredients, (2) an isotonic agent and a solvent, and also can comprise a buffer solution. The solution preparation prepared by adopting a method provided by the invention makes up the blank of the domestic market at present, and the problem that the preparation medicines specially used for inhalation treatment are not available is solved. The solution preparation prepared by adopting the method provided by the invention is specially designed for aerosol inhalation patients, and is matched with an atomizer for use, the use process is convenient and rapid, compared with acute bronchitis syrup, the acute bronchitis solution preparation has the advantages that the administration route is different, the using dosage is reduced, and the safety is improved.

Description

technical field [0001] The invention relates to a solution preparation for atomized inhalation of acute bronchitis and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Cough, sputum, wheezing, and inflammation are the common main symptoms of lower respiratory tract infection. Lower respiratory tract infection can be divided into acute and chronic. Acute infection is mainly acute trachea-bronchitis, which is inflammation of the bronchial mucosa caused by pathogens such as viruses or bacteria. It is a common and frequently-occurring disease, especially in children and the elderly. Secondary to upper respiratory tract infection, it is often an early manifestation of pneumonia, clinically characterized by cough with (or without) increased bronchial secretions. Chronic bronchitis is a common disease of the elderly. Its main symptoms are long-term repeated coughing and sputum accompanied by wheezing. In acute respiratory infection, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/08A61K9/12A61K36/80A61K36/78A61P11/00A61P11/14A61P11/10
CPCA61K9/0073A61K9/08A61K9/12A61K36/17A61K36/185A61K36/19A61K36/23A61K36/28A61K36/484A61K36/56A61K36/70A61K36/704A61K36/752A61K36/78A61K36/80A61K47/02A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张保献
Owner BEIJING INCREASEPHARM CORP LTD
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