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Preparation method for nanometer preparation of thrombolytic drug released under temperature control

A technology of nano-preparation and thrombolytic drug, which is applied in the field of preparation of nano-preparation, can solve the problems of drug release controllability and precision limitation, and achieve the effect of good biocompatibility

Inactive Publication Date: 2017-08-04
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, endogenous biological signals are often affected by various factors in the internal environment, which limits the controllability and accuracy of drug release.

Method used

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  • Preparation method for nanometer preparation of thrombolytic drug released under temperature control
  • Preparation method for nanometer preparation of thrombolytic drug released under temperature control

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Embodiment 1

[0019] A method for preparing a nano-preparation of a temperature-controlled release of a thrombolytic drug, achieved through the following technical routes:

[0020] A. Synthesis of hydrophobic magnetic ferric iron tetroxide nanoparticles by pyrolysis method: 10.8 g FeCl 3 ·6H 2 O and 36.5g of sodium oleate were placed in a flask, 80 mL of absolute ethanol, 60 mL of distilled water and 140 mL of n-hexane were added, and after ultrasonic mixing, they were reacted in a water bath at 70°C for 4 h; after the reaction, the above The mixed solution was poured into a separatory funnel, and 30 mL of distilled water was added to separate and wash the upper organic layer, and repeated 10 times to obtain oleic acid-modified magnetic particles; then the magnetic particles were mixed with 5.7 g of oleic acid, 200 mL of 1 -Octadecene is mixed, the temperature rises at a rate of 3.3°C per minute up to 320°C, and is kept at 320°C for 30 minutes; then begins to cool, and after the temperatur...

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Abstract

The invention discloses a preparation method for a nanometer preparation of a thrombolytic drug released under temperature control. The method comprises the following steps: taking a thermosensitive magnetic lipidosome as a drug carrier, utilizing a targeting effect of an outside magnetic field to directionally convey the thermosensitive magnetic lipidosome to a thrombus focus and utilizing a magnetic heating effect of an alternating magnetic field to magnetic ferroferric oxide nano-particles to control the release of the thrombolytic drug, thereby realizing the safe conveying and controlled release of the thrombolytic drug. The preparation method has the advantages: 1) the thermosensitive magnetic lipidosome which has already passed the authentication of Food and Drug Administration is used as the drug carrier, so that the thrombolytic drug has excellent biocompatibility; 2) the nanometer preparation can control the release of the thrombolytic drug under the effect of the outside alternating magnetic field; 3) the guiding effect of the magnetic field is utilized to directionally convey the nanometer preparation to the thrombus focus; 4) the overheating generated by the magnetic ferroferric oxide nano-particles under the induction of the alternating magnetic field can promote the thrombus dissolution.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a preparation method of a nano-preparation of temperature-controlled release thrombolytic drugs. Background technique [0002] Thrombosis can block the coronary lumen, thereby inducing acute myocardial infarction and leading to death. In recent years, the incidence of myocardial infarction in China has been on the rise, with at least 500,000 new cases each year. At present, the most direct and effective way to treat myocardial infarction is percutaneous coronary intervention (PCI), but patients need to be sent to hospitals with PCI conditions within a certain period of time, which has a certain time limit. For patients with acute myocardial infarction, intravenous injection of thrombolytic drugs can effectively alleviate the condition in a timely manner, so that patients have sufficient time to go to a hospital with PCI conditions for further treatment. However, intravenous ...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/02A61P7/02C01G49/08
CPCA61K9/1277A61K9/0004A61K9/0009A61K9/1271A61K47/02C01G49/08
Inventor 丁星伟
Owner NANCHANG UNIV
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