Application of LRP5 in clinical diagnosis and inhibition of digestive system neoplasm

Abstract

The invention belongs to the field of biological medicines, and concretely relates to application of LRP5 in clinical diagnosis and inhibition of digestive system neoplasm. According to the application of the LRP5 in clinical diagnosis and inhibition of the digestive system neoplasm, an expression situation of the LRP5 in a digestive system neoplasm is detected through fluorogenic quantitative PCR (Polymerase Chain Reaction), and the LRP5 is adopted as a molecular marker for early diagnosis of the digestive system neoplasm according to the expression situation of the LRP5. The application of the LRP5 in the inhibition of the digestive system neoplasm comprises the steps of adopting the LRP5 as a target regulatory gene for building a carrier interfering LRP5 gene expressing; utilizing the built carrier for preparing a medicine for applying in vitro or in vivo. A large number of experimental data proves that the LRP5 has an important regulating effect on the occurrence and development process of the digestive system neoplasm, the proliferation and the migration of the digestive system neoplasm are remarkably inhibited by interfering the LRP5 gene expression, and the LRP5 hopefully becomes a new material for preparing a medicine for preventing and curing the digestive system neoplasm.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of LRP5 as a clinical diagnosis and inhibition of digestive system tumors. Background technique [0002] With the development of social economy and changes in diet, the incidence of tumors has increased significantly. Tumors of the digestive system have high morbidity and mortality, which seriously threaten human life and health. Tumors of the digestive tract mainly include liver cancer, stomach cancer, gallbladder cancer, esophageal cancer, pancreatic cancer, and colorectal cancer. The digestive system is one of the main systems of the human body. The occurrence of tumors has a similar physiological basis, but the cause and exact molecular mechanism are not completely clear, and the specific types of tumors are not the same. It is the result of multiple factors such as environment, genetics, immunity and endocrine. Among them, the occurrence of gastric cancer ...

AI Technical Summary

Problems solved by technology

Studies have shown that abnormal forms of LRP5 protein can be detected in breast cancer and parathyroid cancer tissues; the expression level of LRP5 protein in malignant osteosarcoma tissues is also significantly increased, and LRP5 gene mutations can inhibit the expression of β in osteosarcoma Saos-2 cells. -catenin protein into the nucleus, and significantly reduce the invasion ability of cells; Knocking out the LRP5 gene in prostate cancer cells can inhibit the migration of cancer cells and the volume of malignant tumors in animals. Abnormally elevated levels of LRP5 were detected, suggesting that LRP5 may function as an oncogene, but the relationship between LRP5 and digestive system tumorigenesis has not been reported

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