Application of cerium nitrate in the preparation of flavonoids by fermentation of Aspergillus niger

Abstract

The invention provides application of cerium nitrate to preparation of a flavonoid compound through aspergillus niger fermentation. According to the application, the cerium nitrate or the cerium nitrate and 4-cumaric acid are added into a culture medium; then, aspergillus niger is inoculated; fermentation culture is performed to obtain the flavonoid compound. Through experiments, the cerium nitrate or the cerium nitrate and the 4-cumaric acid are added, so that the total quantity for synthesizing the flavonoid compound by the aspergillus niger can be increased; the cerium nitrate or the cerium nitrate and the 4-cumaric acid can be considered to be added as stimulating factors into industrial application of producing flavonoid through fermentation; the yield of the flavonoid compound is improved.

Description

Technical field[0001]The invention relates to the application of cerium nitrate in preparing flavonoids by fermentation of Aspergillus niger.Background technique[0002]Flavonoids refer to a class of compounds in which two benzene rings are connected to each other through the central three carbon atoms. C6-C3-C6Is its basic structure, has a variety of physiological functions and medicinal value, can lower blood sugar, anti-depression, anti-cancer, and it is widely found in plants. The basic skeleton of flavonoids is synthesized by three malonyl-CoA and one coumarin-CoA. The biosynthetic pathway is short and it has great advantages in the synthesis of microorganisms. At present, the main strains that produce flavonoids are Streptomyces superficialis, Aspergillus niger, Saccharopolyspora rubrum, Rhizopus, Lactobacillus and so on. Of course, flavonoids can also be synthesized in vitro by chemical methods, but chemical methods generally have serious environmental pollution and low safety....

AI Technical Summary

Problems solved by technology

The above studies have shown that rare earth elements are widely and deeply related to the physiology and function of organic cells, but there are no reports on the effect of rare earth elements on the synthesis of flavonoids in cells

This not only shows that the scope of research on the physiological effects of rare earth elements needs to be expanded, but also shows that there is no effective experience for the study of the effects of rare earth elements on the synthesis of flavonoids.

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