Binder used for simulating aptyalia pathological oral environment and application thereof
A saliva-deficient and pathological technology, applied in the field of stomatology materials, can solve the problems of adhesion failure, degeneration of the contamination layer, and obstruction of the remineralization process, so as to achieve remineralization, inhibit the progression of caries, and achieve good adhesion. effect of effect
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[0035] A method for preparing an adhesive for simulating a pathological oral environment lacking saliva, characterized in that it comprises the following steps:
[0036] A, be mixed with tetraglycerol dimethacrylate and ethoxylated bisphenol A dimethacrylate according to the ratio of 1:1 according to mass ratio, obtain mixture;
[0037] B, adding phenyl bis(2,4,6-trimethylbenzoyl) phosphorus oxide to the mixture obtained in step A;
[0038] C, adding hydroxyethyl methacrylate and bisphenol A glycidyl methacrylate to the mixture obtained in step B to obtain PEHB;
[0039] D. Mix PEHB and amorphous phosphoric acid nanoparticles in a mass ratio of 3:2 to obtain the desired binder.
[0040] An application of a binder for simulating a pathological oral environment lacking saliva, used in conjunction with a solution of polyamide-amine dendrimers whose terminal groups are amino groups; the method of use is to use a concentration of 1mg / mL end group is the polyamide-amine type dendr...
Embodiment 1
[0060] The above-mentioned simulated oral environment was used for the experiment, and the concentration of calcium and phosphorus ions in the lactic acid solution immersed in the sample was measured on the 1st, 3rd, 5th, 7th, 10th and 14th day respectively; 1 mL of the solution was collected each time to determine the calcium and phosphorus ions by spectrophotometry Concentration, while adding an equal amount of new lactic acid solution.
[0061] Calcium and phosphorus ion concentration measurement results are as follows: figure 2 As shown, it can be seen from the figure that the concentration of calcium and phosphorus ions in the PAMAM group and the control group solution is almost 0; both the NACP group and the PAMAM+NACP group have calcium and phosphorus ions released from the NACP binder, due to the renewal of the lactic acid solution , the concentration of calcium and phosphorus ions showed a decreasing trend from the first day to the 14th day; on the 14th day, the calc...
Embodiment 2
[0063] The above-mentioned simulated oral environment was used to carry out the experiment, and the pH of the lactic acid solution immersed in the sample was measured on the 1st, 3rd, 5th, 7th, 10th and 14th days (initial pH was 4); the sample was soaked in the lactic acid solution 24 hours a day, The lactic acid solution was replaced every 24 hours; the pH electrode monitored the pH of the lactic acid solution in real time.
[0064] Test results such as image 3 As shown, the pH value of the lactic acid solution in the PAMAM group and the control group was basically maintained at 4; the lactic acid solution in the NACP group and the PAMAM+NACP group rose to 6.1 at 15 minutes on the first day, 6.5 at 60 minutes, and 6.9 at 3 hours; Maintained at 6.9 at 24 hours; due to the renewal of lactic acid solution, the pH value showed a slight downward trend with time; on the 14th day, the lactic acid solution rose to 5.5 at 15 minutes, and rose to 6.5 at 3 hours; the pH values of the...
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