Method for preparing baicalin monolayer osmotic pump tablets
A baicalin single-layer, osmotic pump tablet technology, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, coatings, etc., can solve the problem of slow dissolution rate and low bioavailability of ordinary tablets, etc. problem, to achieve the effect of reducing volatilization, no pharmacological activity, and large dosage
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Embodiment 1
[0107] Example 1: Preparation of Baicalin Monolayer Osmotic Pump Tablets
[0108] The implementation steps of this embodiment are as follows:
[0109] A, prepare baicalin solid dispersion
[0110] The mixture of polyvinylpyrrolidone k30 and polysorbate-80 according to the weight ratio of 4:1 is dissolved in absolute ethanol solvent to obtain a mixture solution, wherein the ratio of the mixture in grams to absolute ethanol in milliliters It is 1:5, and then add baicalin to the mixture solution, so that the weight ratio of baicalin to the mixture is 1:10; then the mixture solution containing baicalin is heated at an inlet temperature of 120°C, an outlet temperature of 90°C, Spray-dry at a flow rate of 3ml / min and an atomization flow rate of 40L / h, pass through a 80-mesh sieve to obtain the baicalin solid dispersion, and then quickly move it into a light-proof desiccator at room temperature, keep it away from light, and store in an airtight manner;
[0111] B. Preparation of ta...
Embodiment 2
[0117] Example 2: Preparation of baicalin monolayer osmotic pump tablet
[0118] The implementation steps of this embodiment are as follows:
[0119] A, prepare baicalin solid dispersion
[0120] The mixture of polyvinylpyrrolidone k30 and polysorbate-80 according to the weight ratio of 4:1 is dissolved in absolute ethanol solvent to obtain a mixture solution, wherein the ratio of the mixture in grams to absolute ethanol in milliliters It is 1:4, and then add baicalin to the mixture solution, so that the weight ratio of baicalin to the mixture is 1:5; then the mixture solution containing baicalin is heated at an inlet temperature of 120°C, an outlet temperature of 90°C, Spray-dry at a flow rate of 3ml / min and an atomization flow rate of 40L / h, pass through a 80-mesh sieve to obtain the baicalin solid dispersion, and then quickly move it into a light-proof desiccator at room temperature, keep it away from light, and store in an airtight manner;
[0121] B. Preparation of tabl...
Embodiment 3
[0127] Example 3: Preparation of Baicalin Monolayer Osmotic Pump Tablets
[0128] The implementation steps of this embodiment are as follows:
[0129] A, prepare baicalin solid dispersion
[0130] The mixture of polyvinylpyrrolidone k30 and polysorbate-80 according to the weight ratio of 4:1 is dissolved in absolute ethanol solvent to obtain a mixture solution, wherein the ratio of the mixture in grams to absolute ethanol in milliliters It is 1:2, and then add baicalin to the mixture solution, so that the weight ratio of baicalin to the mixture is 1:8; then the mixture solution containing baicalin is heated at an inlet temperature of 120°C, an outlet temperature of 90°C, Spray-dry at a flow rate of 3ml / min and an atomization flow rate of 40L / h, pass through a 80-mesh sieve to obtain the baicalin solid dispersion, and then quickly move it into a light-proof desiccator at room temperature, and keep it in an airtight place in the dark;
[0131] B. Preparation of tablet core
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