Method for preparing baicalin monolayer osmotic pump tablets

A baicalin single-layer, osmotic pump tablet technology, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, coatings, etc., can solve the problem of slow dissolution rate and low bioavailability of ordinary tablets, etc. problem, to achieve the effect of reducing volatilization, no pharmacological activity, and large dosage

Inactive Publication Date: 2017-08-11
CHENGDE MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because baicalin is insoluble in water, the dissolution rate in water is relatively slow, resulting in relatively low bioavailability of ordinary tablets prepared by it.

Method used

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  • Method for preparing baicalin monolayer osmotic pump tablets
  • Method for preparing baicalin monolayer osmotic pump tablets
  • Method for preparing baicalin monolayer osmotic pump tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Example 1: Preparation of Baicalin Monolayer Osmotic Pump Tablets

[0108] The implementation steps of this embodiment are as follows:

[0109] A, prepare baicalin solid dispersion

[0110] The mixture of polyvinylpyrrolidone k30 and polysorbate-80 according to the weight ratio of 4:1 is dissolved in absolute ethanol solvent to obtain a mixture solution, wherein the ratio of the mixture in grams to absolute ethanol in milliliters It is 1:5, and then add baicalin to the mixture solution, so that the weight ratio of baicalin to the mixture is 1:10; then the mixture solution containing baicalin is heated at an inlet temperature of 120°C, an outlet temperature of 90°C, Spray-dry at a flow rate of 3ml / min and an atomization flow rate of 40L / h, pass through a 80-mesh sieve to obtain the baicalin solid dispersion, and then quickly move it into a light-proof desiccator at room temperature, keep it away from light, and store in an airtight manner;

[0111] B. Preparation of ta...

Embodiment 2

[0117] Example 2: Preparation of baicalin monolayer osmotic pump tablet

[0118] The implementation steps of this embodiment are as follows:

[0119] A, prepare baicalin solid dispersion

[0120] The mixture of polyvinylpyrrolidone k30 and polysorbate-80 according to the weight ratio of 4:1 is dissolved in absolute ethanol solvent to obtain a mixture solution, wherein the ratio of the mixture in grams to absolute ethanol in milliliters It is 1:4, and then add baicalin to the mixture solution, so that the weight ratio of baicalin to the mixture is 1:5; then the mixture solution containing baicalin is heated at an inlet temperature of 120°C, an outlet temperature of 90°C, Spray-dry at a flow rate of 3ml / min and an atomization flow rate of 40L / h, pass through a 80-mesh sieve to obtain the baicalin solid dispersion, and then quickly move it into a light-proof desiccator at room temperature, keep it away from light, and store in an airtight manner;

[0121] B. Preparation of tabl...

Embodiment 3

[0127] Example 3: Preparation of Baicalin Monolayer Osmotic Pump Tablets

[0128] The implementation steps of this embodiment are as follows:

[0129] A, prepare baicalin solid dispersion

[0130] The mixture of polyvinylpyrrolidone k30 and polysorbate-80 according to the weight ratio of 4:1 is dissolved in absolute ethanol solvent to obtain a mixture solution, wherein the ratio of the mixture in grams to absolute ethanol in milliliters It is 1:2, and then add baicalin to the mixture solution, so that the weight ratio of baicalin to the mixture is 1:8; then the mixture solution containing baicalin is heated at an inlet temperature of 120°C, an outlet temperature of 90°C, Spray-dry at a flow rate of 3ml / min and an atomization flow rate of 40L / h, pass through a 80-mesh sieve to obtain the baicalin solid dispersion, and then quickly move it into a light-proof desiccator at room temperature, and keep it in an airtight place in the dark;

[0131] B. Preparation of tablet core

...

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Abstract

The invention relates to a method for preparing baicalin monolayer osmotic pump tablets. The method includes steps of preparing baicalin solid dispersion; preparing tablet cores; preparing coating solution; carrying out coating and drying, and the like. The solid dispersion is prepared by the aid of mixture carriers of PVPk30 and polysorbate-80 by the aid of solvent-spray drying techniques. The method has the advantages that absolute ethyl alcohol is used as a reagent, is convenient to recycle and extremely low in influence on environments and human bodies, is inexpensive and is easily available; coating membranes PEG 400 are low in dosage, accordingly, the production costs of the baicalin monolayer osmotic pump tablets can be reduced, environmental pollution can be abated, and economic burden on patients can be relieved; the baicalin monolayer osmotic pump tablets are prepared by the aid of direct tabletting techniques, technological processes are simple, the medicine stability, the medicine dissolution and the disintegration can be improved, and accordingly the method is obviously superior in economical efficiency.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of traditional Chinese medicine pharmacy. More specifically, the present invention relates to a preparation method of baicalin monolayer osmotic pump tablet. [0003] 【Background technique】 [0004] The traditional Chinese medicine Scutellaria baicalensis is the dry root of Scutellaria baicalensis Georgi. It is bitter in nature and cold in taste, and returns to the lung, gallbladder, spleen, large intestine, and small intestine meridian. It has the functions of clearing away heat and dampness, purging fire and detoxification, hemostasis, and anti-abortion. , all herbal medicines have been recorded in successive dynasties. [0005] Baicalin is a flavonoid compound extracted from the traditional Chinese medicine Scutellaria baicalensis. Modern pharmacological studies have shown that baicalin has anti-inflammatory, antipyretic, liver protection, anti-virus, scavenging oxygen free radicals, anti-oxidat...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/36A61K31/7048A61K47/32A61K47/26A61K47/10A61P1/16
CPCA61K9/0002A61K9/2018A61K9/2027A61K9/2031A61K9/2853A61K9/2866A61K31/7048
Inventor 王汝兴刘翠哲刘喜纲李忠思常金花刘沛薛禾菲
Owner CHENGDE MEDICAL UNIV
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