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Preparation method of magnetic/gold nano composite particle

A technology of composite particles and gold nanometers, applied in nanotechnology, metal processing equipment, coatings, etc., can solve problems such as cumbersome steps

Inactive Publication Date: 2017-08-11
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the problem faced by the preparation of the composite particles is that the steps are relatively cumbersome. Generally speaking, the magnetic core is first prepared by the co-precipitation method, and then the surface is modified by amination to endow the surface of the core with a positive charge. In addition, the magnetic core is obtained by reducing chloroauric acid. Composite structure
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  • Preparation method of magnetic/gold nano composite particle
  • Preparation method of magnetic/gold nano composite particle

Examples

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Effect test

Embodiment 1

[0018] (1) Add 10 ml of ethylene glycol to a three-necked flask, weigh 0.08 g of polyglutamic acid and add it to fully dissolve; add 0.27 g of polyethyleneimine with a molecular weight of 25000 to another 3 ml of ethylene glycol and sonicate until it is completely dissolved; Add 0.65 g FeCl to 20 ml ethylene glycol 3 • 6H 2 O and 1.65 g NH 4 After OAc is sonicated until it is completely dissolved and uniformly dispersed, mix the above three ethylene glycol solutions and continue to ultrasonically disperse uniformly;

[0019] (2). Place the three-necked flask containing the glycol solution in step (1) in an electric heating mantle set to 160 ℃ and continue to heat and stir for 15 minutes. The mixed solution was transferred to a stainless steel reactor with a polytetrafluoroethylene liner, heated at 200 ℃ for 12 hours, and the product was washed three times with ethanol and deionized water; a 50 mL reactor can obtain 80-100 mg of magnetic material in one reaction. The average parti...

Embodiment 2

[0022] (1) Add 10 ml of ethylene glycol to the three-necked flask, weigh 0.09 g of hyaluronic acid and add it to fully dissolve; add 0.27 g of polyethyleneimine with a molecular weight of 600 to the other 3 ml of ethylene glycol and sonicate until it is completely dissolved; Add 0.65 g FeCl to 20 ml ethylene glycol 3 • 6H 2 O and 1.65 g NH 4 After OAc is sonicated until it is completely dissolved and uniformly dispersed, mix the above three ethylene glycol solutions and continue to ultrasonically disperse uniformly;

[0023] (2). Place the three-necked flask containing the glycol solution in step (1) in an electric heating mantle set to 160 ℃ and continue to heat and stir for 15 minutes. The mixed solution was transferred to a stainless steel reactor with a polytetrafluoroethylene liner, heated at 200 ℃ for 15 hours, and the product was washed three times with ethanol and deionized water; a 50-mL reactor can obtain 50-80 mg of magnetic material in one reaction. The average parti...

Embodiment 3

[0026] (1) Add 10 ml of ethylene glycol into the three-necked flask, weigh 0.08 g of chitosan and add it to fully dissolve it; add 0.27 g of polyethyleneimine with a molecular weight of 25000 to the other 3 ml of ethylene glycol until it is completely dissolved; Add 0.65 g FeCl to ml ethylene glycol 3 • 6H 2 O and 1.65 g NH 4 After OAc is sonicated until it is completely dissolved and uniformly dispersed, mix the above three ethylene glycol solutions and continue to ultrasonically disperse uniformly;

[0027] (2). Place the three-necked flask containing the glycol solution in step (1) in an electric heating mantle set to 160 ℃ and continue to heat and stir for 15 minutes. The mixed solution was transferred to a stainless steel reactor with a polytetrafluoroethylene liner, heated at 200 ℃ for 12 hours, and the product was washed three times with ethanol and deionized water; a 50 mL reactor can obtain 80-100 mg of magnetic material in one reaction. The average particle size is 180...

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Abstract

The invention relates to a preparation method of a core-shell magnetic / gold nano composite particle. Firstly, a magnetic Fe3O4 nano cluster is prepared through a solvothermal method and wrapped with macromolecules possessing positive electricity in situ in the preparation process, the magnetic cluster modified with the macromolecules is used as a seed, chloroauric acid is subjected to mild reduction directly through a one-step method, core forming and growth of a gold particle on the surface of a magnetic inner core are finished by one step, and therefore, the magnetic / gold nano composite particle is obtained. The nano particle is good in water dispersibility, has superparamagnetism and is high in magnetic response. The composite particle is 80-250 nm in diameter and can be used for the fields such as drug and gene delivery, photo-thermal therapy and protein nucleic acid separation and enrichment.

Description

Technical field [0001] The invention relates to a method for preparing magnetic / gold nano composite particles. Background technique [0002] Magnetism / gold (or gold magnetism) nanocomposite particles have attracted much attention because of their integration of optical properties such as the magnetic functional core and the plasmon resonance of gold nanoparticles, and the ease of surface modification. A large number of documents and patents reported the preparation methods and technologies of magnetic / gold composite nanoparticles. The current problem in the preparation of the composite particles is: the steps are relatively cumbersome. Generally speaking, the magnetic core is prepared by the co-precipitation method, and then the surface is modified by amination to give the core surface a positive charge. In addition, it is obtained by the reduction of chloroauric acid. Composite structure. (Peng Mingli, Jin Yanyan, Cui Yali, Tian Zhimin, Xing Yan, Tang Lina, Chinese Patent, Pub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/02B82Y40/00
CPCB82Y40/00B22F9/24B22F1/17
Inventor 王祎龙杨子
Owner TONGJI UNIV
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