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Method for preparing thermo-sensitive drug-release composite

A composite material and temperature-sensitive technology, which is applied in the direction of effective components of heterocyclic compounds and sheet-like transportation, can solve the problems of unavoidable use of organic solvents, complicated synthesis and preparation process, and uncontrollable drug loading, so as to improve the mechanical properties , good biocompatibility, overcome the effect that is difficult to control precisely

Inactive Publication Date: 2017-08-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Aiming at the shortcomings of traditional temperature-sensitive drug release materials, such as poor biocompatibility, complex synthesis and preparation process, unavoidable use of organic solvents, and uncontrollable drug loading, the purpose of the present invention is to propose a melt blending A method for preparing a temperature-sensitive drug release composite material that is biodegradable, safe and non-toxic, with excellent mechanical properties, continuous production, and flexible and controllable drug release behavior. This method can improve the drug and dispersed phase in the biodegradable polymer matrix The dispersed state of the drug realizes the temperature-responsive release of the drug in a simple solvent-free process and has good mechanical properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A polycaprolactone (matrix) / glycerol trilaurate (disperse phase) / sodium diclofenac (drug) temperature-sensitive drug release composite material includes the following components and their contents in parts by weight:

[0042] Component Parts by weight

[0043] Polycaprolactone (for biodegradable polymer matrix) 90

[0044] Glyceryl trilaurate (a dispersed phase of hydrophobic biodegradable small molecules) 10

[0045] Diclofenac sodium (as a drug) 5

[0046] Explanation: the weight of diclofenac sodium (being a medicine) is 5% of the total weight of the biodegradable polymer matrix and the dispersed phase.

[0047] The first step, at first prepare raw materials by above-mentioned components;

[0048] In the second step, the above materials were dried in a vacuum oven at 40°C for 12 hours;

[0049] In the third step, the dried polycaprolactone, glycerol trilaurate, and sodium diclofenac obtained in the second step are placed together in a high-mixer and pre-mixed for...

Embodiment 2

[0056] The raw materials of a polybutylene succinate (matrix) / glycerol tristearate (disperse phase) / metoprolol tartrate (drug) temperature-sensitive drug release composite material include the following components and parts by weight :

[0057] Component Parts by weight

[0058] Polybutylene succinate (for biodegradable polymer matrix) 80

[0059] Glycerol tristearate (a dispersed phase of hydrophobic biodegradable small molecules) 20

[0060] Metoprolol tartrate (as drug) 10

[0061] Explanation: the weight of metoprolol tartrate (being medicine) is 5% of the total weight of biodegradable polymer matrix and dispersed phase.

[0062] The first step, at first prepare raw materials by above-mentioned components;

[0063] In the second step, the polybutylene succinate and metoprolol tartrate were dried in a vacuum oven at 60°C for 12 hours, and glycerol tristearate was dried in a vacuum oven at 40°C for 12 hours;

[0064] In the third step, the dry polybutylene succinate, gl...

Embodiment 3

[0071] A raw material of ethyl cellulose (matrix) / tripalmitin-lauric acid (disperse phase) / cephalexin (drug) temperature-sensitive drug release composite material includes the following components and contents in parts by weight:

[0072] Component Parts by weight

[0073] Ethyl cellulose (for biodegradable polymer matrix) 80

[0074] Glyceryl tripalmitate (a hydrophobic biodegradable small molecule dispersed phase 1) 15

[0075] Lauric acid (as the dispersed phase of hydrophobic biodegradable small molecules 2) 5

[0076] Cephalexin (as a drug) 5

[0077] Explanation: the weight of cephalexin (being a medicine) is 5% of the total weight of the biodegradable polymer matrix and the dispersed phase.

[0078] The first step, at first prepare raw materials by above-mentioned components;

[0079] In the second step, the ethyl cellulose and cephalexin were dried in a vacuum oven at 60°C for 12 hours, and the tripalmitin and lauric acid were dried in a vacuum oven at 35°C for 12 ...

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Abstract

The invention provides a method for preparing a thermo-sensitive drug-release composite. The method mainly comprises steps as follows: biodegradable polymers are taken as a matrix, hydrophobic biodegradable ester compounds are taken as a dispersion phase, the biodegradable polymer matrix and the hydrophobic biodegradable micromolecular dispersion phase with a relatively low melting point in the weight percentage being (50%-99%):(50%-1%) and a drug with the weight accounting for 0.01%-40% of the total weight of the biodegradable polymer matrix and the hydrophobic biodegradable micromolecular dispersion phase with a relatively low melting point are subjected to melting mixing, so that uniform loading of the drug in the biodegradable polymer matrix is realized, the thermo-sensitive drug-release composite with good temperature response drug-release performance and mechanical performance is prepared, and the thermo-sensitive controllable releasing of the drug is realized. The method is safe, non-toxic and simple in process, quality indexes of products in different batches are stable, large-scale continuous production can be realized, and the method has remarkable research value and application prospects in the field of drug controlled release.

Description

technical field [0001] The invention relates to a preparation method of a temperature-sensitive drug release composite material, and more specifically relates to a method for preparing a biodegradable, safe and non-toxic compound material by melt blending, with excellent mechanical properties, continuous production, and flexible drug release behavior. The invention discloses a method for releasing composite materials with controlled temperature-sensitive drugs, and belongs to the technical field of functional composite materials. Background technique [0002] With the rapid development of medical technology and the demand for intelligent drug delivery systems, stimulus-responsive drug delivery systems that can sense changes in the internal state and external environmental stimuli to regulate drug release have emerged. Among them, the temperature-sensitive drug release system is simple and easy to control the drug release behavior, which can be carried out by heating or cooli...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K47/38A61K47/14A61K47/12A61K47/10A61K31/196A61K31/138A61K31/4422A61K31/522A61K31/545
CPCA61K9/70A61K31/138A61K31/196A61K31/4422A61K31/522A61K31/545A61K47/10A61K47/12A61K47/14A61K47/34A61K47/38
Inventor 陈蓉周虹汛郭少云
Owner SICHUAN UNIV