Magnetic nano-targeted oxidized graphene drug carrier and preparation method and application thereof

A magnetic nanometer and graphene technology, applied in the field of medicine, can solve problems such as single treatment mode of tumors, and achieve the effects of good water solubility, stability and good biocompatibility

Inactive Publication Date: 2017-08-18
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, whether it is basic research or clinical trials, the magnetic induction hyperthermia of carrier magnetic nanocomposite particles is used in the single treatment mode of tumor, or the comprehensive treatment mode of tumor magnetic induction combined with this treatment method and other treatment methods, especially the combination of chemotherapy drugs and There are few reports on the combined use of temperature-controlled materials for magnetic induction thermochemotherapy of tumors

Method used

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  • Magnetic nano-targeted oxidized graphene drug carrier and preparation method and application thereof
  • Magnetic nano-targeted oxidized graphene drug carrier and preparation method and application thereof
  • Magnetic nano-targeted oxidized graphene drug carrier and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] One, the preparation method of graphene oxide

[0065] Add 98% H to the flask 2 SO 4 , and moved into an ice-water bath to stir, and the stable temperature was below 10°C; then added the mixture of flake graphite and sodium nitrate, stirred to make it fully mixed; then added potassium permanganate, reacted for 2 hours below 10°C, and then moved into a 35°C React in a water bath for 12 hours; after the reaction, slowly inject deionized water into it and stir to dissolve it, then react at 98°C for 15 minutes, add 30% H to the reaction solution while it is hot 2 o 2 and stirring, after no bubbles are generated, add 8% HCl solution, stir evenly, perform centrifugal washing, remove the colloid in the lower layer and freeze-dry to obtain graphene oxide. Wherein the mass ratio of flake graphite, sodium nitrate, and potassium permanganate is 1:0.5:5; every 1g flake graphite adds 23mL of 98%H 2 SO 4 .

[0066] 2. Magnetic nano-targeted graphene oxide drug carrier GO-Fe 3 ...

Embodiment 2

[0073] One, the preparation method of graphene oxide

[0074] Add 98% H to the flask 2 SO 4 , and moved into an ice-water bath to stir, the stable temperature is below 10°C; then add the mixture of flake graphite and sodium nitrate, stir to make it fully mixed; then add potassium permanganate, react at below 10°C for 2.5h, and then move to 35°C React in a water bath for 13 hours; after the reaction, slowly inject deionized water into it and stir to dissolve it, then react at 98°C for 20 minutes, add 30% H to the reaction solution while it is hot 2 o 2 And stir, add 12% HCl solution after no bubbles are generated, centrifuge and wash after stirring evenly, take the lower colloid and freeze-dry to obtain graphene oxide. Among them, the mass ratio of flake graphite, sodium nitrate, and potassium permanganate is 2:1.5:7; add 25mL of 98% H for every 1g of flake graphite 2 SO 4 .

[0075] 2. Magnetic nano-targeted graphene oxide drug carrier GO-Fe 3 o 4 -The preparation meth...

Embodiment 3

[0082] One, the preparation method of graphene oxide

[0083] Add 98% H to the flask 2 SO 4 , and moved into an ice-water bath to stir, and the stable temperature was below 10°C; then added the mixture of flake graphite and sodium nitrate, stirred to make it fully mixed; then added potassium permanganate, reacted below 10°C for 2.3h, and then moved to 35°C React in a water bath for 12.5 hours; after the reaction, slowly inject deionized water into it and stir to dissolve it, then react at 98°C for 18 minutes, add 30% H to the reaction solution while it is hot 2 o 2 and stirring, after no bubbles are generated, add 10% HCl solution, stir evenly, perform centrifugal washing, remove the colloid in the lower layer and freeze-dry to obtain graphene oxide. Among them, the mass ratio of flake graphite, sodium nitrate, and potassium permanganate is 2:1:6; add 24mL of 98% H to every 1g of flake graphite 2 SO 4 .

[0084] 2. Magnetic nano-targeted graphene oxide drug carrier GO-Fe...

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Abstract

The invention discloses a magnetic nano-targeted oxidized graphene drug carrier and a preparation method and an application method thereof. The preparation method comprises the following steps: using oxidized graphene, FeCl3.6H2O, sodium acetate and aniline monomer as raw materials, and using a chemical coprecipitation method and an in-situ synthesis method to obtain the magnetic nano-targeted oxidized graphene drug carrier; the mass ratio of the oxidized graphene, FeCl3.6H2O, sodium acetate and aniline monomer is 7-8: 23-25: 47-49: 0.5-1.5. The prepared magnetic nano-targeted oxidized graphene drug carrier GO-Fe3O4-PANI is a anti-cancer novel targeted oxidized graphene drug carrier, wherein the oxidized graphene drug carrier is based on magnetic targeting and drug-carrying function, combines multiple functions of magnetic therapy, thermal therapy and chemotherapy, has good biocompatibility, water solubility and stability, has magnetic targeting property and thermal therapy effect, and has photo-thermal therapy, targeted chemotherapy and other multifunctional multi-dimensional cancer treatment effects loaded with anti-tumor drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a magnetic nano-targeted graphene oxide drug carrier and a preparation method and application thereof. Background technique [0002] Cancer is a persistent disease that has not been overcome by human beings. It is estimated that by 2030, there will be 26 million new cancer cases worldwide, and the number of deaths will jump to 17 million, most of which will occur in low- and middle-income developing countries. Cancer is becoming a new phenomenon. The first killer of human beings in the century and has become the largest public health problem in the world. Malignant tumors have caused a large number of labor losses and a large consumption of social resources. According to the World Health Organization (WHO) report, my country has become the world's second largest cancer-incidence area; according to the data released by the Ministry of Health of my country, malignant t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/02A61K47/34A61K33/24A61P35/00
CPCA61K41/00A61K33/24A61K41/0052A61K47/02A61K47/34
Inventor 李雪华蒙法艳杨艳芳李福森黄燕军黄静吴妮妮田海芬邓永恒韦丽莹邓诗发
Owner GUANGXI MEDICAL UNIVERSITY
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