A kind of magnetic fluorescent bifunctional graphene oxide nanocomposite material and preparation method thereof

A nanocomposite material and dual-function technology, which is applied in the direction of luminescent materials, chemical instruments and methods, nanotechnology, etc., can solve the problems that the biological safety of cadmium-containing quantum dots has not been fundamentally solved, and the decomposition cannot be completely eliminated, and has reached a large scale. The effect of medical application value

Active Publication Date: 2016-04-13
深圳特新界面科技有限公司
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  • Abstract
  • Description
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Problems solved by technology

Although the preparation, structure and performance detection of cadmium-containing quantum dots are very mature, and a large number of studies have shown that the stability and safety of Cd-containing quantum dots can be greatly improved by using surface modification technology or aqueous phase synthesis method, but it still cannot completely eliminate this problem. Quantum-like dots will decompose into free Cd during use 2+ Therefore, the biological safety of cadmium-containing quantum dots has not been fundamentally resolved.

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  • A kind of magnetic fluorescent bifunctional graphene oxide nanocomposite material and preparation method thereof
  • A kind of magnetic fluorescent bifunctional graphene oxide nanocomposite material and preparation method thereof
  • A kind of magnetic fluorescent bifunctional graphene oxide nanocomposite material and preparation method thereof

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Embodiment 1

[0028] (1) Preparation of graphene oxide

[0029] Add 2g graphite powder to 25g concentrated H 2 SO 4 , 2.5gK 2 S 2 O 8 and 2.5gP 2 O 5 The mixture was reacted at 80°C for 3h. It was then diluted with 500 ml of water and washed by filtration to remove excess acid. The obtained pre-product was dried at room temperature overnight, then the pre-oxidized graphite was added to 100 ml of concentrated H 2 SO 4 , gradually add 13g KMnO under the protection of an ice-water bath 4 , the mixture was stirred and reacted at 35 °C for 30 min, then reacted at 85 °C for 2 h, then diluted with water, boiled and reacted for 30 min, stirred for 1 hour, added 500 ml of water, 20 ml and 30% H 2 O 2 The solution was left to settle. The mixture was filtered and washed 5 times with 1:10 dilute hydrochloric acid and then with water until neutral. Finally, the obtained product was purified by dialysis for one week to remove the remaining metal ions, and the obtained graphite oxide was ultr...

Embodiment 2

[0039] (1) Preparation of graphene oxide

[0040] Add 2g graphite powder to 25g concentrated H 2 SO 4 , 2.5gK 2 S 2 O 8 and 2.5gP 2 O 5 In the mixed solution, the reaction was carried out at 70 °C for 5 h. It was then diluted with 500 ml of water and washed by filtration to remove excess acid. The obtained pre-product was dried at room temperature overnight, then the pre-oxidized graphite was added to 150 ml of concentrated H 2 SO 4 , gradually add 20g KMnO under the protection of an ice-water bath 4 , the mixture was stirred and reacted at 30 °C for 30 min, then reacted at 85 °C for 2 h, then diluted with water, boiled for 30 min, stirred for 1 hour, and then added with 500 ml of water, 20 ml and 30% H 2 O 2 The solution was left to settle. The mixture was filtered and washed 5 times with 1:10 dilute hydrochloric acid and then with water until neutral. Finally, the obtained product was purified by dialysis for one week to remove the remaining metal ions, and the ...

Embodiment 3

[0050] (1) Preparation of graphene oxide

[0051] Add 2g graphite powder to 25g concentrated H 2 SO 4 , 2.5gK 2 S 2 O 8 and 2.5gP 2 O 5 The mixture was reacted at 80°C for 3h. It was then diluted with 500 ml of water and washed by filtration to remove excess acid. The obtained pre-product was dried at room temperature overnight, then the pre-oxidized graphite was added to 100 ml of concentrated H 2 SO 4 , gradually add 13g KMnO under the protection of an ice-water bath 4 , the mixture was stirred and reacted at 35 °C for 30 min, then reacted at 85 °C for 2 h, then diluted with water, boiled and reacted for 30 min, stirred for 1 hour, added 500 ml of water, 20 ml and 30% H 2 O 2 The solution was left to settle. The mixture was filtered and washed 5 times with 1:10 dilute hydrochloric acid and then with water until neutral. Finally, the obtained product was purified by dialysis for one week to remove the remaining metal ions, and the obtained graphite oxide was ultr...

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Abstract

The invention relates to a magnetic-fluorescent integrated multifunctional graphene oxide nanocomposite and a preparation method thereof and belongs to the technical field of the inorganic nano materials. The preparation method comprises the following steps: preparing ZnO quantum dots and Fe3O4 nanoparticles having a mesoporous structure, respectively, and then covering the two types of nanoparticles with a SiO2 shell layer and performing amination on the nanoparticles; grafting the aminated nanoparticles on the surface of the graphene oxide treated by surface carboxylation previously in a covalent crosslinking way, and finally obtaining a magnetic-fluorescent difunctional graphene oxide nanocomposite. The graphene oxide nanocomposite prepared by use of the preparation method has obvious magnetic properties; due to extremely large specific surface area of the graphene oxide, the graphene oxide nanocomposite has bright application prospect in the aspect of the drug targeting transport carriers; besides, due to excellent fluorescent properties, the transport path of the graphene oxide nanocomposite when used as a drug carrier can be traced.

Description

technical field [0001] The invention belongs to the technical field of inorganic nanomaterials and biomedicine, in particular to a magnetic fluorescent bifunctional graphene oxide nanocomposite material which can be used as a targeted drug carrier and a preparation method thereof. Background technique [0002] The most widely used graphene derivatives in the field of biomedicine are mainly functionalized graphene oxide. In recent years, metal nanoparticles and magnetic nanoparticles are loaded on the surface of graphene oxide to prepare composite materials, and their application in materials, chemistry, Research on applications in fields such as biomedicine is developing rapidly. At present, the existing domestic and foreign researches on its application in biomedicine are mainly used in biological imaging, biological detection, tumor treatment and drug carrier, and these studies have achieved gratifying results. Research aspects of graphene oxide as a drug carrier: First, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/54
CPCB82Y20/00B82Y30/00B82Y40/00C09K11/025C09K11/54C09K11/65
Inventor 张艳华黄磊肖巍邓莹于弘陈慧刘煌孙兰兰
Owner 深圳特新界面科技有限公司
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