Novel tangerine pith extract product as well as preparation method thereof and intestine moistening and bowel relaxing medical applications

A technology of extract and citrus, which is applied in the field of medicine, can solve the problems of reduced pectin activity, achieve the effects of lowering the pH value, inhibiting the growth of harmful intestinal bacteria, and achieving rapid and significant detoxification effects

Inactive Publication Date: 2017-08-22
杭州络通生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It adopts the method of cutting off the straight chain of pectin to reduce the molecular weight, which will lead to a decrease in the activity of pectin

Method used

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  • Novel tangerine pith extract product as well as preparation method thereof and intestine moistening and bowel relaxing medical applications
  • Novel tangerine pith extract product as well as preparation method thereof and intestine moistening and bowel relaxing medical applications
  • Novel tangerine pith extract product as well as preparation method thereof and intestine moistening and bowel relaxing medical applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Such as figure 1 Shown is a kind of method for preparing tangerine complex extract, and this method comprises the following steps:

[0038] 1) Handling of raw materials

[0039] After crushing, cleaning, and drying, the citrus tangerines enter the acid extraction tank, and are heated to 40-50°C, and the pH is adjusted to 3.5-4.5 with acid (HCl), and the temperature is kept for 4 hours.

[0040] 2) filter

[0041] The liquid after leaching is filtered to remove the residue, the filtrate is taken into the extraction tank, and the filter residue is subjected to secondary leaching.

[0042] 3) Extraction

[0043] The leached liquid enters the extraction tank, and the extract is added to perform polymer pectin extraction, and the extracted extract enters the squeezing device to obtain polymer pectin.

[0044] 4) Recover the extract

[0045] The extract is recovered through an extraction recovery device, and the remaining part of the extract is the raw material liquid of...

Embodiment 2

[0053] 1.1 Materials

[0054] Obtained in Example 1, the finished product is a brown suspension. After determination, every 100ml contains small molecule pectin ≥ 2000mg, citrus flavonoids (VP) ≥ 400mg, and total solid content ≥ 4500mg.

[0055] 1.2 Animals and Grouping

[0056] 150 clean-grade (level II) Kunming male mice weighing 22-25 g were provided by the Experimental Animal Center of the Academy of Military Medical Sciences. Set up three doses of 0.2, 0.4, 0.8ml / (25g bw) (respectively equivalent to 5, 10, 20 times the recommended dose of the human body) in the experimental group, and set up a constipation model control group and a negative control group, 15 rats in each group animal.

[0057] 1.3 Method

[0058] According to the "Technical Standards for Inspection and Evaluation of Health Food" (2003 Edition), "test method for laxative function", the specific method is as follows:

[0059] 1.3.1 Small intestine motility test

[0060] Each experimental group was orall...

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Abstract

The invention relates to the field of medicine, in particular to a novel citrus complex extract and its preparation method and application. A new type of citrus tangerine extract, the extract includes small molecule pectin and citrus flavonoids prepared by physical separation of the extract after extracting high molecular pectin from citrus tangerine, and the extract contains small molecule pectin per 100ml ≥2000mg, citrus flavonoids≥400mg. The small-molecule pectin and citrus flavonoids of the citrus tangerine extract of the present invention belong to natural composite components and have a good effect on laxative and laxative.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a novel citrus complex extract and its preparation method and application. Background technique [0002] Citrus pectin is a polysaccharide derived from plant cell walls. It can generally be used as a food additive. It has good gelling, stabilizing, emulsifying, thickening, and suspending functions. Similarly, natural citrus pectin has a large molecular weight (5-300,000 Da ), cannot be absorbed by the intestinal tract after eating and cannot make it fully function in the body. In view of this, modifying the size and structure of its molecules has the prospect of enhancing biological functions. [0003] Several main methods of pectin modification, including chemical (pH) modification, enzyme modification, thermal modification, irradiation modification, graft modification, cross-linking modification and substitution modification; [0004] At present, the small molecule pectin extraction t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K31/732A23L33/105A23L33/21A23L29/231A61P1/10
CPCA61K36/752A23V2002/00A61K31/732A61K2236/33A61K2236/39A61K2236/53
Inventor 叶兴乾高海峰邓致荣
Owner 杭州络通生物科技有限公司
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