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Composition and solid preparation of classical heat-clearing and detoxification prescription

A heat-clearing and detoxifying and composition technology, which is applied in the direction of anti-toxins, drug combinations, antipyretics, etc., can solve the problems of unguaranteed decoction quality, no improvement, dosage of auxiliary materials, and difficulty in swallowing.

Inactive Publication Date: 2017-08-29
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the quality of the decoction cannot be guaranteed at all, thus affecting the clinical efficacy
At the same time, for modern people whose life and work rhythm is accelerating day by day, the decoction still has many problems and disadvantages in taking, carrying, transporting, storing, etc.
In contrast to the modern preparations currently on the market, although granules and concentrated powders have solved the problems of portability and transportation, they have basically not improved in terms of improving the taste and reducing the pain of patients taking medicine; tablets have made achievements in both aspects. However, the dosage and swallowing difficulties caused by the large amount of excipients are still problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: dosage form selection

[0015] Huanglian Jiedu Decoction is a classic prescription in Qingrejiedu prescriptions. It was first recorded in "Elbow Reserve Emergency Prescription" by Ge Hong in the Eastern Jin Dynasty, and it was named "Waitai Secret Yao". It has the effect of clearing heat, purging fire and detoxifying, and it is mainly used to treat all diseases of excess heat, fire toxin and excessive heat of triple burner. It is often used for severe fever, irritability, dry mouth and throat, wrong speech, insomnia; or febrile disease vomiting blood, epistaxis; or severe fever spotting, body heat diarrhea, damp-heat jaundice; surgical carbuncle furunculosis, yellow urine, red tongue with yellow coating , The pulse is strong.

[0016] Volume 2 of "Elbow Reserve Emergency Prescriptions" "The Thirteenth Prescription for Temperament Diseases when Treating Typhoid Fever" says: "The other prescription is three liang of Coptis chinensis, two liang each of Phell...

Embodiment 2

[0018] Embodiment 2: Composition extraction process research

[0019] 1. Identification and pretreatment of herbal decoction pieces

[0020] Coptis decoction pieces: This product uses the dried rhizomes of Coptis chinensis Franch., Coptisdeltoidea C. Y. Cheng et Hsiao or Coptis teeta Wall. of Ranunculaceae. Remove impurities, cut into thin slices after moistening, dry, or mash when used. This product complies with the relevant provisions of the 2010 edition of "Pharmacopoeia of the People's Republic of China" under the item of Coptis chinensis.

[0021] Scutellaria baicalensis decoction pieces: This product uses the dry root of Scutellaria baicalensis, a plant of the Labiatae family. Remove impurities, cook in boiling water for 10 minutes, take it out, stuff it thoroughly, cut into thin slices, and dry; or steam for half an hour, take out, cut into thin slices, and dry (be careful not to expose to the sun). This product complies with the relevant regulations under Section 1...

Embodiment 3

[0039] Embodiment 3: Research on molding process of concentrated pill preparation

[0040]The pure extract powder, extract powder+microcrystalline cellulose and extract powder+starch were investigated respectively, with water and refined honey as binders, and the method of preparation was investigated. Based on the principle of reducing the dosage of preparations, and taking the molding condition, roundness, and uniformity of pills as the inspection indicators, the pill molding process was studied.

[0041] 0

[0042] 0

[0043] Uniformity (ε) evaluation criteria:

[0044] Evaluation method: refer to the item "Content Uniformity Inspection" in the appendix of "Chinese Pharmacopoeia", and use the weight of the pill as an index to check the uniformity of the preparation. Take 10 pills of Huanglian Jiedu pills, measure the weight of the pills respectively, and calculate the average weight of the pills as the marked amount. Calculate the relative weight of each...

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PUM

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Abstract

The present invention mainly relates to the composition and the solid preparation of a classical heat-clearing and detoxification prescription coptis chinensis detoxification decoction, and preparation methods thereof. According to the present invention, a ratio of coptis chinensis to scutellaria baicalensis to cortex phellodendri to cape jasmine in the classical formula is 3:2:2:3; the composition is obtained by extracting and processing through a standard and classical boiling process according to the texture and the property of the herbs; the solid preparation is concentrated pills formed by combining the composition and a reasonable auxiliary material preparation, has effects of heat clearing, pathogenic fire reducing and detoxification, mainly treats all excessive heat fire toxin and three-jiao excessive heat, and is generally used for treating fever and irritability, dry mouth and throat, paraphasia, agrypnia, or pyretic hematemesis and non-traumatic hemorrhage, or eruption caused by excessive heat, pyretic diarrhea, dampness-heat jaundice, and surgical carbuncle, cellulitis and furunculosis, yellowish or reddish urine, red tongue with yellowish fur, and powerful rapid pulse; the composition is obtained by extracting and processing through the traditional standard boiling process on the basis of the assurance of the classical formula ratio; and the solid preparation is formed through the repeated exploration and practice, has advantages of stable and controllable quality, good taste, easy taking, easy carrying, easy storage, easy transportation and the like, and is the optimal selection of the classical coptis chinensis detoxification prescription solid oral dosage.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a classic heat-clearing and detoxifying prescription—Huanglian Jiedu Decoction. The composition and its solid preparation are obtained by extracting, separating and processing the prescription composed of Coptis chinensis, Scutellaria baicalensis, Phellodendron phellodendri, and gardenia (3:2:2:3), and are used to treat fever, vexation, swelling and pain of gums , Teeth bleeding, constipation, painful urination, red tongue with yellow coating, rapid pulse, etc. are all symptoms of excessive heat, fire and poison, and excessive heat in the triple burner. Background technique [0002] Huanglian Jiedu Decoction is a classic prescription for clearing heat and detoxifying composed of four traditional Chinese medicines: Coptis chinensis, Scutellaria baicalensis, Phellodendron Phellodendron and Gardenia. It has the effect of clearing heat, purging fire and detoxif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/30A61P29/00A61P39/02
CPCA61K9/2054A61K9/282A61K36/539A61K36/718A61K36/744A61K36/756A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 边宝林司南王宏洁杨健赵海誉
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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