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Salmon calcitonin soluble microneedle patch and preparation method thereof

A salmon calcitonin, soluble technology, applied in the direction of microneedle, needle, sheet delivery, etc., can solve the problem of no salmon calcitonin soluble microneedle research and other problems

Active Publication Date: 2020-10-27
广州新济生物医药研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no report on the study of salmon calcitonin-soluble microneedles

Method used

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  • Salmon calcitonin soluble microneedle patch and preparation method thereof
  • Salmon calcitonin soluble microneedle patch and preparation method thereof
  • Salmon calcitonin soluble microneedle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation of Salmon Calcitonin Soluble Microneedle Patch

[0047] The preparation method of the salmon calcitonin soluble microneedle patch of the present embodiment is as follows:

[0048] (1) sCT / Dex-Tre microneedle preparation solution: Weigh 2.5mg sCT and dissolve it in 50μL deionized water, and take another 25mg dextran 40 (molecular weight is 40000), and 12.5mg D-trehalose dihydrate are dissolved in the above solution, Swell overnight to prepare sCT / Dex-Tre microneedle preparation solution.

[0049] (2) Blank base solution: Dissolve 50 mg of polyvinylpyrrolidone K90 (PVPK90, molecular weight: 1,100,000) in 150 μL of ethanol, stir evenly, and swell overnight to prepare blank base solution K90E.

[0050] (3) Microneedle patch preparation

[0051] Inject the sCT / Dex-Tre microneedle body preparation solution into the microneedle female mold, centrifuge for 10 minutes under the force of 3000g, and the centrifugation temperature is 4°C. After the solution fi...

Embodiment 2

[0057] The preparation method of the salmon calcitonin soluble microneedle patch of the present embodiment is as follows:

[0058] (1) sCT / Dex-Tre microneedle preparation solution: Weigh 2.7mg sCT and dissolve in 50μL deionized water, and take another 24.3mg dextran 40 (molecular weight 40000), 10.8mg D-trehalose dihydrate and dissolve in the above solution , and swell overnight to prepare the sCT / Dex-Tre microneedle preparation solution.

[0059] Other steps are the same as in Example 1.

Embodiment 3

[0061] The preparation method of the salmon calcitonin soluble microneedle patch of the present embodiment is as follows:

[0062] (1) sCT / Dex-Tre microneedle preparation solution: Weigh 2.3mg sCT and dissolve it in 50μL deionized water, and take another 25.3mg dextran 40 (molecular weight 40000), 13.8mg D-trehalose dihydrate and dissolve it in the above solution , and swell overnight to prepare the sCT / Dex-Tre microneedle preparation solution.

[0063] Other steps are the same as in Example 1.

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Abstract

The invention relates to a salmon calcitonin soluble microneedle patch and a preparation method thereof. The salmon calcitonin soluble microneedle patch is composed of a substrate and a needle body, the needle body is prepared from a mixed solution of salmon calcitonin, dextran and trehalose, the mass ratio of salmon calcitonin to dextran to trehalose is 1:5-20:4-8; and the substrate is prepared from a solution of a water soluble polymer material. The salmon calcitonin soluble microneedle patch has the advantages of good mechanical strength, good stability, good effect of reducing blood calcium and high bioavailability. The addition of the trehalose can facilitates the improvement of the stability of the salmon calcitonin and the transdermal drug release efficiency of a microneedle, the bioavailability of the salmon calcitonin is improved, and a higher effect of reducing the blood calcium can be achieved.

Description

technical field [0001] The invention relates to the technical field of transdermal administration, in particular to a salmon calcitonin soluble microneedle patch and a preparation method thereof. Background technique [0002] Osteoporosis (osteoporosis, OP) is a common senile disease. With the aging of the population in China, the number of patients suffering from osteoporosis is also increasing exponentially, which has brought serious harm to the society, patients and patients' families. troubled. Osteoporosis is a systemic degenerative disease of the skeletal system characterized by a negative balance of bone resorption greater than bone remodeling, resulting in decreased bone strength and increased bone fragility. get shorter. Within 1 year after the fracture occurs, 20% of patients die from various complications, and 50% of the survivors become disabled. Therefore, the treatment of osteoporosis is a very realistic and important problem. Its treatment is mainly to redu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/23A61K9/70A61K47/36A61K47/26A61P19/10A61M37/00
CPCA61K9/0021A61K38/23A61K47/26A61K47/36A61M37/0015A61M2037/0023
Inventor 陈航平李革任春艳温新国
Owner 广州新济生物医药研究院有限公司
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