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Preparation of amorphous calcium phosphate/polylactic acid electrostatic spinning bracket

An amorphous calcium phosphate and electrospinning technology, applied in medical science, prosthesis, etc., can solve the problems of limited donor sources, secondary injury of patients, and limited capacity, and achieve real-time monitoring of the operation process and good biocompatibility Sexuality and degradability, the effect of promoting osseointegration

Inactive Publication Date: 2017-09-05
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although bone tissue itself has a strong self-repair ability, its ability is very limited and can only be performed in the case of small defects. For defects that cannot be repaired by themselves, allogeneic or autologous bone grafts are usually used. However, autologous or allogeneic bone Transplantation will cause secondary damage to the patient, and the source of donors is very limited

Method used

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  • Preparation of amorphous calcium phosphate/polylactic acid electrostatic spinning bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Preparation of amorphous calcium phosphate precursor by chemical wet method

[0022] In the experiment, the amorphous calcium phosphate precursor was prepared by chemical wet method, and 2.95g Ca(NO 3 ) 2 4H 2 O and 0.99g (NH 4 ) 2 HPO 4 Ensure that Ca / P=1.67, dissolve with 20mL of distilled water respectively, and obtain 12.5mmol of Ca(NO 3 ) 2 4H 2 O and 7.5mmol of (NH 4 ) 2 HPO 4 solution. Slowly drop the solution containing calcium ions into the solution containing phosphate, stir slowly with a glass rod to mix the solution evenly, and adjust the pH of the solution with ammonia water to keep the pH value of the reaction system at about 7.4. The obtained mixture was poured into a 50mL centrifuge tube, centrifuged at 3000rpm for 3min, and freeze-dried to obtain amorphous calcium phosphate powder, which was ready for use.

Embodiment 2

[0023] Example 2: Preparation of polylactic acid electrospinning scaffold

[0024] Pipette 7mL of dichloromethane and 3mL of N,N-dimethylformamide into a small beaker to make a mixed solvent, weigh 9g of polylactic acid with a balance and dissolve it in the mixed solvent to obtain 9% (W / V) PLA electrospinning solution. The prepared spinning solution was transferred into a 20mL syringe for electrospinning. In the experiment, the electrospinning voltage was set to 20kV, the receiving distance was 12cm, and the advancing rate of the syringe pump was 0.4mL / h. Electrospun films of lactic acid.

Embodiment 3

[0025] Example 3: Preparation of polylactic acid electrospinning scaffold

[0026] Use a pipette gun to pipette 7mL of dichloromethane and 3mL of N,N-dimethylformamide into a small beaker to make a mixed solvent, weigh 11g of polylactic acid with a balance and dissolve it in the mixed solvent to obtain 11% (W / V) PLA electrospinning solution. The prepared spinning solution was transferred into a 20mL syringe for electrospinning. In the experiment, the electrospinning voltage was set to 20kV, the receiving distance was 12cm, and the advancing rate of the syringe pump was 0.4mL / h. Electrospun films of lactic acid.

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Abstract

The invention provides a preparation method of a composite nano-fiber material and belongs to the field of biomedical materials. Amorphous calcium phosphate ceramic is added into polylactic acid nano-fibers through an electrostatic spinning method so that the bioactivity of the material is improved; the composite nano-fiber material provides Ca<2+> and PO4<3->, which are used for promoting bone cell proliferation and differentiation, for bone tissue repairing; the polylactic acid can be used as a scaffold material for bone defects; amorphous calcium phosphate is precipitated again and converted into a basic component hydroxyapatite of bone tissues along the formation of new bones; the polylactic acid is degraded in bodies to form CO2 and H2O and then is circularly discharged out of the bodies; the amorphous calcium phosphate is added and inflammatory response caused by acid generated by degradation of the polylactic acid is alleviated. The invention provides a new concept for further development of bone tissue engineering and the preparation method has important theoretical and practical significance.

Description

technical field [0001] The invention belongs to the field of biomedical materials. More specifically, the present invention relates to a preparation method of scaffold material for artificial bone repair. Background technique [0002] Bone defect repair materials are one of the biomedical materials with the greatest clinical demand. There are millions of bone defect patients every year, and there is an increasing trend. The market for bone repair materials is huge. Looking for better bone tissue repair materials It has become a frontier and hot issue in the research of biomedical materials. Although bone tissue itself has a strong self-repair ability, its ability is very limited and can only be performed in the case of small defects. For defects that cannot be repaired by themselves, allogeneic or autologous bone grafts are usually used. However, autologous or allogeneic bone Transplantation will cause secondary damage to the patient, and the source of donors is very limit...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50A61L27/58
Inventor 牛旭锋田丰樊瑜波陈思倩
Owner BEIHANG UNIV
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